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There are 155 purchasable compounds for target: ASCR

Wt: 375.8
BDBM21398
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Wt: 319.8
BDBM22985
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Wt: 267.3
BDBM34856
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Wt: 241.6
BDBM37876
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Wt: 351.1
BDBM39607
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Wt: 367.3
BDBM43247
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Wt: 328.4
BDBM43230
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Wt: 421.4
BDBM43259
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Wt: 248.3
BDBM42858
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Wt: 192.2
BDBM42577
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Wt: 288.3
BDBM42732
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Wt: 386.8
BDBM42714
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Wt: 233.2
BDBM42635
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Wt: 233.2
BDBM42636
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Wt: 219.2
BDBM42597
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Displayed 1 to 15 (of 155 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 21398,22985,34856,37876,39607,43247,43230,43259,42858,42577,42732,42714,42635,42636,42597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prion protein


(Homo sapiens)
BDBM42577
PNG
(5-(2-methylphenyl)-3H-1,3,4-oxadiazole-2-thione | ...)
Show SMILES Cc1ccccc1-c1nnc(S)o1
Show InChI InChI=1S/C9H8N2OS/c1-6-4-2-3-5-7(6)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13)
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n/an/a 5.75E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM22985
PNG
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Show SMILES CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Institut f£r Molekularbiologie und Biophysik

Curated by ChEMBL


Assay Description
Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells


J Med Chem 46: 3563-4 (2003)

More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM37876
PNG
(3-Chloro-6-methoxy-benzo[b]thiophene-2-carboxylic ...)
Show SMILES COc1ccc2c(Cl)c(sc2c1)C(N)=O
Show InChI InChI=1S/C10H8ClNO2S/c1-14-5-2-3-6-7(4-5)15-9(8(6)11)10(12)13/h2-4H,1H3,(H2,12,13)
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n/an/a 2.46E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42635
PNG
(2-(2-quinolinylthio)propanoic acid | 2-(2-quinolyl...)
Show SMILES CC(Sc1ccc2ccccc2n1)C(O)=O
Show InChI InChI=1S/C12H11NO2S/c1-8(12(14)15)16-11-7-6-9-4-2-3-5-10(9)13-11/h2-8H,1H3,(H,14,15)
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n/an/a 1.56E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42636
PNG
(3-(2-quinolinylthio)propanoic acid | 3-(2-quinolyl...)
Show SMILES OC(=O)CCSc1ccc2ccccc2n1
Show InChI InChI=1S/C12H11NO2S/c14-12(15)7-8-16-11-6-5-9-3-1-2-4-10(9)13-11/h1-6H,7-8H2,(H,14,15)
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n/an/a 3.19E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM39607
PNG
(2-(5-bromanylfuran-2-yl)-5-(3,4-dimethoxyphenyl)-1...)
Show SMILES COc1ccc(cc1OC)-c1nnc(o1)-c1ccc(Br)o1
Show InChI InChI=1S/C14H11BrN2O4/c1-18-9-4-3-8(7-11(9)19-2)13-16-17-14(21-13)10-5-6-12(15)20-10/h3-7H,1-2H3
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n/an/a 4.59E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42714
PNG
(MLS000089894 | N-(3-chlorophenyl)-2-[[5-cyano-6-(2...)
Show SMILES Clc1cccc(NC(=O)CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C17H11ClN4O3S/c18-10-3-1-4-11(7-10)20-14(23)9-26-17-21-15(13-5-2-6-25-13)12(8-19)16(24)22-17/h1-7H,9H2,(H,20,23)(H,21,22,24)
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n/an/a 1.69E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42732
PNG
(2-(1-keto-4-methyl-benzothiopheno[2,3-d]pyridazin-...)
Show SMILES CC(C(O)=O)n1nc(C)c2sc3ccccc3c2c1=O
Show InChI InChI=1S/C14H12N2O3S/c1-7-12-11(9-5-3-4-6-10(9)20-12)13(17)16(15-7)8(2)14(18)19/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 8.45E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM43247
PNG
(2-[(5-cyano-4-keto-6-phenyl-1H-pyrimidin-2-yl)thio...)
Show SMILES Cc1cc(NC(=O)CSc2nc(-c3ccccc3)c(C#N)c(=O)[nH]2)no1
Show InChI InChI=1S/C17H13N5O3S/c1-10-7-13(22-25-10)19-14(23)9-26-17-20-15(11-5-3-2-4-6-11)12(8-18)16(24)21-17/h2-7H,9H2,1H3,(H,19,22,23)(H,20,21,24)
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n/an/a 7.14E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42858
PNG
(3-(2-methylquinazolin-4-yl)sulfanylpropanoic acid ...)
Show SMILES Cc1nc(SCCC(O)=O)c2ccccc2n1
Show InChI InChI=1S/C12H12N2O2S/c1-8-13-10-5-3-2-4-9(10)12(14-8)17-7-6-11(15)16/h2-5H,6-7H2,1H3,(H,15,16)
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n/an/a 915n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM34856
PNG
(2-amino-4-(5-methyl-2-thienyl)thiophene-3-carboxyl...)
Show SMILES CCOC(=O)c1c(N)scc1-c1ccc(C)s1
Show InChI InChI=1S/C12H13NO2S2/c1-3-15-12(14)10-8(6-16-11(10)13)9-5-4-7(2)17-9/h4-6H,3,13H2,1-2H3
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n/an/a 1.04E+5n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM43259
PNG
(MLS000621545 | N-({[4-({[amino(imino)methyl]amino}...)
Show SMILES NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C16H15N5O5S2/c17-15(18)21-28(23,24)11-4-2-10(3-5-11)19-16(27)20-14(22)9-1-6-12-13(7-9)26-8-25-12/h1-7H,8H2,(H4,17,18,21)(H2,19,20,22,27)
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n/an/a 1.51E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


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More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM43230
PNG
(2-(7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-d]pyri...)
Show SMILES OC(=O)c1ccccc1Sc1ncnc2sc3CCCc3c12
Show InChI InChI=1S/C16H12N2O2S2/c19-16(20)10-4-1-2-6-12(10)22-15-13-9-5-3-7-11(9)21-14(13)17-8-18-15/h1-2,4,6,8H,3,5,7H2,(H,19,20)
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n/an/a 7.05E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Institut f£r Molekularbiologie und Biophysik

Curated by ChEMBL


Assay Description
Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells


J Med Chem 46: 3563-4 (2003)

More data for this
Ligand-Target Pair
Prion protein


(Homo sapiens)
BDBM42597
PNG
((Quinolin-2-ylsulfanyl)-acetic acid | 2-(2-quinoli...)
Show SMILES OC(=O)CSc1ccc2ccccc2n1
Show InChI InChI=1S/C11H9NO2S/c13-11(14)7-15-10-6-5-8-3-1-2-4-9(8)12-10/h1-6H,7H2,(H,13,14)
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n/an/a 6.89E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


Citation and Details
More data for this
Ligand-Target Pair