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There are 22 purchasable compounds for target: Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b

Compile data set for download or QSAR
Wt: 277.7
BDBM43554
Purchase
Wt: 291.7
BDBM67581
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Wt: 159.1
BDBM50128977
Wt: 362.2
BDBM50347497
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Wt: 288.2
BDBM50412636
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Wt: 322.7
BDBM50412638
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Wt: 268.7
BDBM50412681
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Wt: 258.2
BDBM50412646
Purchase
Wt: 326.2
BDBM50412648
Purchase
Wt: 248.6
BDBM50412655
Purchase
Wt: 245.2
BDBM50412657
Purchase
Wt: 253.7
BDBM50412658
Purchase
Wt: 262.6
BDBM50412660
Purchase
Wt: 237.6
BDBM50412662
Purchase
Wt: 254.6
BDBM50412663
Purchase
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 43554,67581,50128977,50347497,50412636,50412638,50412681,50412646,50412648,50412655,50412657,50412658,50412660,50412662,50412663   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50128977
PNG
(2-Hydroxy-1H-pyrrolo[3,2-b]pyridine-3-carbonitrile...)
Show SMILES O=c1[nH]c2ccc[nH]c2c1C#N
Show InChI InChI=1S/C8H5N3O/c9-4-5-7-6(11-8(5)12)2-1-3-10-7/h1-3,10H,(H,11,12)
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n/an/an/an/a 1.34E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
[86Rb+] efflux induced by BKca alpha subunits expressed in HEK293 cells at 10 microM


Bioorg Med Chem Lett 13: 2003-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00324-x
BindingDB Entry DOI: 10.7270/Q2QN6647
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412681
PNG
(CHEMBL466201)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1nccs1
Show InChI InChI=1S/C11H9ClN2O2S/c1-16-9-3-2-7(12)6-8(9)10(15)14-11-13-4-5-17-11/h2-6H,1H3,(H,13,14,15)
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n/an/a 3.09E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412638
PNG
(CHEMBL464249 | TCMDC-124051)
Show SMILES COc1cc(ccc1NC(=O)c1cc(Cl)ccc1O)[N+]([O-])=O
Show InChI InChI=1S/C14H11ClN2O5/c1-22-13-7-9(17(20)21)3-4-11(13)16-14(19)10-6-8(15)2-5-12(10)18/h2-7,18H,1H3,(H,16,19)
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n/an/a 692n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412646
PNG
(CHEMBL481576)
Show SMILES Oc1ccccc1C(=O)Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C13H10N2O4/c16-12-8-4-1-5-9(12)13(17)14-10-6-2-3-7-11(10)15(18)19/h1-8,16H,(H,14,17)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM67581
PNG
(MLS000050452 | N-(5-chloranyl-2-oxidanyl-phenyl)-2...)
Show SMILES CCOc1ccccc1C(=O)Nc1cc(Cl)ccc1O
Show InChI InChI=1S/C15H14ClNO3/c1-2-20-14-6-4-3-5-11(14)15(19)17-12-9-10(16)7-8-13(12)18/h3-9,18H,2H2,1H3,(H,17,19)
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n/an/a 3.09E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412648
PNG
(CHEMBL519785)
Show SMILES Oc1ccccc1C(=O)Nc1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C14H9F3N2O4/c15-14(16,17)8-5-6-10(11(7-8)19(22)23)18-13(21)9-3-1-2-4-12(9)20/h1-7,20H,(H,18,21)
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n/an/a 3.47E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50347497
PNG
(CHEMBL384903)
Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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n/an/a 5.89E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412655
PNG
(CHEMBL480413)
Show SMILES Oc1ccc(Cl)cc1NC(=O)c1cccnc1
Show InChI InChI=1S/C12H9ClN2O2/c13-9-3-4-11(16)10(6-9)15-12(17)8-2-1-5-14-7-8/h1-7,16H,(H,15,17)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412657
PNG
(CHEMBL480415)
Show SMILES Cc1ccc(O)c(NC(=O)c2ccc(F)cc2)c1
Show InChI InChI=1S/C14H12FNO2/c1-9-2-7-13(17)12(8-9)16-14(18)10-3-5-11(15)6-4-10/h2-8,17H,1H3,(H,16,18)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412658
PNG
(CHEMBL447035)
Show SMILES Oc1ccc(Cl)cc1NC(=O)c1cccs1
Show InChI InChI=1S/C11H8ClNO2S/c12-7-3-4-9(14)8(6-7)13-11(15)10-2-1-5-16-10/h1-6,14H,(H,13,15)
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n/an/a 1.17E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412660
PNG
(CHEMBL504665)
Show SMILES COc1ccc(Cl)cc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-3-2-9(14)8-11(12)13(17)16-10-4-6-15-7-5-10/h2-8H,1H3,(H,15,16,17)
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n/an/a 1.23E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412662
PNG
(CHEMBL463882)
Show SMILES Oc1ccc(Cl)cc1NC(=O)c1ccco1
Show InChI InChI=1S/C11H8ClNO3/c12-7-3-4-9(14)8(6-7)13-11(15)10-2-1-5-16-10/h1-6,14H,(H,13,15)
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n/an/a 1.51E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412663
PNG
(CHEMBL468265)
Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H7ClN2O2S/c11-6-1-2-8(14)7(5-6)9(15)13-10-12-3-4-16-10/h1-5,14H,(H,12,13,15)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM43554
PNG
(MLS000078111 | N-(5-chloranyl-2-oxidanyl-phenyl)-2...)
Show SMILES COc1ccccc1C(=O)Nc1cc(Cl)ccc1O
Show InChI InChI=1S/C14H12ClNO3/c1-19-13-5-3-2-4-10(13)14(18)16-11-8-9(15)6-7-12(11)17/h2-8,17H,1H3,(H,16,18)
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n/an/a 1.86E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair
Calcium-activated potassium channel alpha/beta 1


(Homo sapiens (Human))
BDBM50412636
PNG
(CHEMBL453712)
Show SMILES COc1ccc(cc1NC(=O)c1ccccc1O)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O5/c1-21-13-7-6-9(16(19)20)8-11(13)15-14(18)10-4-2-3-5-12(10)17/h2-8,17H,1H3,(H,15,18)
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n/an/a 447n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel-mediated vasorelaxation activity assessed as reduction in KCl-induced contractile tone


Bioorg Med Chem 17: 319-25 (2008)


Article DOI: 10.1016/j.bmc.2008.10.068
BindingDB Entry DOI: 10.7270/Q2P84D59
More data for this
Ligand-Target Pair