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There are 7 purchasable compounds for target: Acrosin

Wt: 340.4
BDBM45440
Wt: 120.1
BDBM50038002
Wt: 470.1
BDBM50098554
Wt: 332.8
BDBM50354886
Wt: 312.3
BDBM50368092
Wt: 312.3
BDBM50405347
Wt: 261.2
BDBM50436618

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 45440,50038002,50098554,50354886,50368092,50405347,50436618   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acrosin


(Sus scrofa)
BDBM50098554
PNG
(4-(3-{4-[amino(imino)methyl]-2-bromophenoxy}propox...)
Show SMILES NC(=N)c1ccc(OCCCOc2ccc(cc2Br)C(N)=N)c(Br)c1
Show InChI InChI=1S/C17H18Br2N4O2/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23)
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1.70E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis


J Med Chem 21: 1132-6 (1979)

More data for this
Ligand-Target Pair
Acrosin


(Sus scrofa)
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
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2.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis


J Med Chem 21: 1132-6 (1979)

More data for this
Ligand-Target Pair
Acrosin


(Sus scrofa)
BDBM50368092
PNG
(GNF-PF-3839 | PROPAMIDINE CHLORIDE)
Show SMILES NC(=N)c1ccc(OCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C17H20N4O2/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H3,18,19)(H3,20,21)
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3.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis


J Med Chem 21: 1132-6 (1979)

More data for this
Ligand-Target Pair
Acrosin


(Sus scrofa)
BDBM50038002
PNG
(Benzamidine (Protonated) | CHEMBL20936 | CHEMBL537...)
Show SMILES NC(=N)c1ccccc1
Show InChI InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)
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4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as substrate by Dixon plot analysis


J Med Chem 21: 1132-6 (1979)

More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50354886
PNG
(CHEMBL466465)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
Show InChI InChI=1S/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3/t13-/m0/s1
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n/an/a 1.43E+8n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human acrosin using N-alpha-benzoyl-DL-arginine para-nitroanilide-HCl as substrate after 3 hrs by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50354886
PNG
(CHEMBL466465)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
Show InChI InChI=1S/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3/t13-/m0/s1
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n/an/a 1.43E+8n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human sperm acrosin using BAPNA as substrate after 3 hrs by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50405347
PNG
(CHEMBL539058)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccc(cc2)N=C(N)N)cc1
Show InChI InChI=1S/C16H16N4O3/c1-10(21)19-12-6-8-14(9-7-12)23-15(22)11-2-4-13(5-3-11)20-16(17)18/h2-9H,1H3,(H,19,21)(H4,17,18,20)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human acrosin and control activity being 11.3 umol/min/mg


J Med Chem 29: 514-9 (1986)

More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50354886
PNG
(CHEMBL466465)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
Show InChI InChI=1S/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3/t13-/m0/s1
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n/an/a 1.43E+8n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of acrosin in human spermatozoa assessed as effect on amidase activity after 3 hrs incubation by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50354886
PNG
(CHEMBL466465)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
Show InChI InChI=1S/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3/t13-/m0/s1
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n/an/a 1.43E+8n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of acrosin activity in human spermatozoa using N-alpha-benzoyl-DL-arginine para-nitroanilide-HCI as a substrate after 3 hrs by spectrophot...


Citation and Details
More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50354886
PNG
(CHEMBL466465)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
Show InChI InChI=1S/C14H21ClN2O3S/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16/h5-8,13,17H,2-4,9-10,16H2,1H3/t13-/m0/s1
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PubMed
n/an/a 1.43E+8n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human acrosin using N-alpha-benzoyl-DL-arginine para-nitroanilide-HCl as substrate after 3 hrs by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Acrosin


(Homo sapiens)
BDBM50436618
PNG
(CHEMBL2397958)
Show SMILES COc1ccc(cc1)-c1cc([nH]n1)C(=O)NCCO
Show InChI InChI=1S/C13H15N3O3/c1-19-10-4-2-9(3-5-10)11-8-12(16-15-11)13(18)14-6-7-17/h2-5,8,17H,6-7H2,1H3,(H,14,18)(H,15,16)
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n/an/a 9.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human sperm acrosin using BAPNA as substrate after 3 hrs by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair