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There are 10 purchasable compounds for target: Alkaline phosphatase placental type

Wt: 405.4
BDBM76212
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Wt: 405.4
BDBM76213
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Wt: 389.4
BDBM76214
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Wt: 386.3
BDBM76215
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Wt: 172.1
BDBM50080274
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Wt: 204.2
BDBM50241179
Purchase
Wt: 260.3
BDBM50443975
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Wt: 389.4
BDBM50447439
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Wt: 375.3
BDBM50447440
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Wt: 419.4
BDBM50447447
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 76212,76213,76214,76215,50080274,50241179,50443975,50447439,50447440,50447447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50080274
PNG
(Benzyl-phosphonic acid | CHEMBL299737 | Phenyl-met...)
Show SMILES OP(O)(=O)Cc1ccccc1
Show InChI InChI=1S/C7H9O3P/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,8,9,10)
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Article
PubMed
5.80E+5n/an/an/an/an/an/an/an/a



University of Campinas

Curated by ChEMBL


Assay Description
Inhibition of human placental alkaline phosphatase using p-nitrophenyl phosphate substrate


Bioorg Med Chem 23: 4462-71 (2015)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
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n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by substr...


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM76215
PNG
(CHEMBL1349252 | MLS001096095 | N-(3-cyanophenyl)-3...)
Show SMILES O=C(CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)Nc1cccc(c1)C#N
Show InChI InChI=1S/C17H14N4O5S/c18-10-11-2-1-3-12(8-11)20-16(22)6-7-19-27(24,25)13-4-5-14-15(9-13)26-17(23)21-14/h1-5,8-9,19H,6-7H2,(H,20,22)(H,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM76212
PNG
(3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N...)
Show SMILES COc1ccccc1CNC(=O)CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1
Show InChI InChI=1S/C18H19N3O6S/c1-26-15-5-3-2-4-12(15)11-19-17(22)8-9-20-28(24,25)13-6-7-14-16(10-13)27-18(23)21-14/h2-7,10,20H,8-9,11H2,1H3,(H,19,22)(H,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM76213
PNG
(3-[(2-keto-3H-1,3-benzoxazol-6-yl)sulfonylamino]-N...)
Show SMILES COc1cccc(CNC(=O)CCNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)c1
Show InChI InChI=1S/C18H19N3O6S/c1-26-13-4-2-3-12(9-13)11-19-17(22)7-8-20-28(24,25)14-5-6-15-16(10-14)27-18(23)21-15/h2-6,9-10,20H,7-8,11H2,1H3,(H,19,22)(H,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
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n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubate...


Bioorg Med Chem 21: 7981-7 (2013)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50447440
PNG
(CHEMBL1363800)
Show SMILES O=C(CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)NCc1ccccc1
Show InChI InChI=1S/C17H17N3O5S/c21-16(18-11-12-4-2-1-3-5-12)8-9-19-26(23,24)13-6-7-14-15(10-13)25-17(22)20-14/h1-7,10,19H,8-9,11H2,(H,18,21)(H,20,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50447447
PNG
(CHEMBL3115122)
Show SMILES O=C(CCNS(=O)(=O)c1ccc2[nH]c(=O)oc2c1)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C18H17N3O7S/c22-17(19-9-11-1-4-14-16(7-11)27-10-26-14)5-6-20-29(24,25)12-2-3-13-15(8-12)28-18(23)21-13/h1-4,7-8,20H,5-6,9-10H2,(H,19,22)(H,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM76214
PNG
(CHEMBL1322977 | MLS001096094 | N-(2,5-dimethylphen...)
Show SMILES Cc1ccc(C)c(NC(=O)CCNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)c1
Show InChI InChI=1S/C18H19N3O5S/c1-11-3-4-12(2)15(9-11)20-17(22)7-8-19-27(24,25)13-5-6-14-16(10-13)26-18(23)21-14/h3-6,9-10,19H,7-8H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50443975
PNG
(CHEMBL3092296)
Show SMILES C1CN2CC(N=C2S1)c1cc2ccccc2s1
Show InChI InChI=1S/C13H12N2S2/c1-2-4-11-9(3-1)7-12(17-11)10-8-15-5-6-16-13(15)14-10/h1-4,7,10H,5-6,8H2
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n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubat...


Bioorg Med Chem 21: 7981-7 (2013)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
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Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubat...


Bioorg Med Chem 21: 7981-7 (2013)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50443975
PNG
(CHEMBL3092296)
Show SMILES C1CN2CC(N=C2S1)c1cc2ccccc2s1
Show InChI InChI=1S/C13H12N2S2/c1-2-4-11-9(3-1)7-12(17-11)10-8-15-5-6-16-13(15)14-10/h1-4,7,10H,5-6,8H2
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CHEMBL
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Article
PubMed
n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubate...


Bioorg Med Chem 21: 7981-7 (2013)

More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
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n/an/a>4.00E+5n/an/an/an/an/an/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by subst...


Citation and Details
More data for this
Ligand-Target Pair
Alkaline phosphatase placental type


(Homo sapiens)
BDBM50447439
PNG
(CHEMBL1347946)
Show SMILES Cc1ccc(NC(=O)CCNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)cc1C
Show InChI InChI=1S/C18H19N3O5S/c1-11-3-4-13(9-12(11)2)20-17(22)7-8-19-27(24,25)14-5-6-15-16(10-14)26-18(23)21-15/h3-6,9-10,19H,7-8H2,1-2H3,(H,20,22)(H,21,23)
PDB
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged PLAP (unknown origin) expressed in African green monkey COS1 cells after 30 mins by chemiluminescence assay


Bioorg Med Chem Lett 24: 1000-4 (2014)

More data for this
Ligand-Target Pair