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There are 9 purchasable compounds for target: Amiloride-sensitive cation channel 3

Wt: 229.6
BDBM16173
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Wt: 164.2
BDBM50342655
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Wt: 163.2
BDBM50342656
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Wt: 159.1
BDBM50342657
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Wt: 173.2
BDBM50342658
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Wt: 170.2
BDBM50342659
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Wt: 212.0
BDBM50342652
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Wt: 170.2
BDBM50342653
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Wt: 171.1
BDBM50342654
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 16173,50342655,50342656,50342657,50342658,50342659,50342652,50342653,50342654   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Bioorg Med Chem Lett 19: 2514-8 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342652
PNG
(6-bromo-1,2,3,4-tetrahydroisoquinoline | CHEMBL177...)
Show SMILES Brc1ccc2CNCCc2c1
Show InChI InChI=1S/C9H10BrN/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-2,5,11H,3-4,6H2
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n/an/a 7.01E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342653
PNG
(6-phenylpyridin-2-amine | CHEMBL1671950)
Show SMILES Nc1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C11H10N2/c12-11-8-4-7-10(13-11)9-5-2-1-3-6-9/h1-8H,(H2,12,13)
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n/an/a 7.63E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342654
PNG
(6-phenylpyrimidin-4-amine | CHEMBL1770733)
Show SMILES Nc1cc(ncn1)-c1ccccc1
Show InChI InChI=1S/C10H9N3/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,12,13)
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n/an/a 1.30E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342659
PNG
(2-phenylpyridin-4-amine | CHEMBL1770738)
Show SMILES Nc1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C11H10N2/c12-10-6-7-13-11(8-10)9-4-2-1-3-5-9/h1-8H,(H2,12,13)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342656
PNG
(CHEMBL1770735 | benzo[b]thiophen-2-ylmethanamine)
Show SMILES NCc1cc2ccccc2s1
Show InChI InChI=1S/C9H9NS/c10-6-8-5-7-3-1-2-4-9(7)11-8/h1-5H,6,10H2
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PubMed
n/an/a 9.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342657
PNG
(4-(1H-imidazol-4-yl)aniline | CHEMBL1770736)
Show SMILES Nc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C9H9N3/c10-8-3-1-7(2-4-8)9-5-11-6-12-9/h1-6H,10H2,(H,11,12)
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n/an/a 4.30E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342658
PNG
((4-(1H-imidazol-4-yl)phenyl)methanamine | CHEMBL17...)
Show SMILES NCc1ccc(cc1)-c1c[nH]cn1
Show InChI InChI=1S/C10H11N3/c11-5-8-1-3-9(4-2-8)10-6-12-7-13-10/h1-4,6-7H,5,11H2,(H,12,13)
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PubMed
n/an/a 1.60E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342655
PNG
(2-ethyl-1H-indene | CHEMBL1770734)
Show SMILES NCc1nc2ccccc2s1
Show InChI InChI=1S/C8H8N2S/c9-5-8-10-6-3-1-2-4-7(6)11-8/h1-4H,5,9H2
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n/an/a 3.63E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair