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There are 5 purchasable compounds for target: AKT1 kinase

Wt: 256.3
BDBM50034417
Wt: 409.6
BDBM50304369
Wt: 461.4
BDBM50299148
Wt: 298.3
BDBM50304370
Wt: 1050.9
BDBM50338966

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034417,50304369,50299148,50304370,50338966   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Mus musculus)
BDBM50338966
PNG
(CHEMBL1685065 | Phosphatidylinositol(3,4,5)-trisph...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC
Show InChI InChI=1S/C41H82O22P4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)57-31-33(59-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-58-67(55,56)63-38-36(44)39(60-64(46,47)48)41(62-66(52,53)54)40(37(38)45)61-65(49,50)51/h33,36-41,44-45H,3-32H2,1-2H3,(H,55,56)(H2,46,47,48)(H2,49,50,51)(H2,52,53,54)/t33-,36+,37+,38-,39+,40-,41-/m1/s1
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500n/an/an/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Mus musculus)
BDBM50304369
PNG
(4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonam...)
Show SMILES CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C20H31N3O2S2/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)27(24,25)23-20-22-21-17-26-20/h13-17H,2-12H2,1H3,(H,22,23)
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2.40E+3n/an/an/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Mus musculus)
BDBM50034417
PNG
(4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)
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>5.00E+4n/an/an/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Mus musculus)
BDBM50304370
PNG
(CHEMBL593946 | N-(4-(N-1,3,4-thiadiazol-2-ylsulfam...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nncs1
Show InChI InChI=1S/C10H10N4O3S2/c1-7(15)12-8-2-4-9(5-3-8)19(16,17)14-10-13-11-6-18-10/h2-6H,1H3,(H,12,15)(H,13,14)
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>5.00E+4n/an/an/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Mus musculus)
BDBM50299148
PNG
((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Show SMILES C[C@]1(CCCN1c1nc(Nc2cc([nH]n2)C2CC2)c2cccn2n1)C(=O)Nc1ccc(F)nc1
Show InChI InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of Akt phosphorylation in mouse Sal cells by western blotting


Citation and Details
More data for this
Ligand-Target Pair