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There are 3 purchasable compounds for target: Arginase-2, mitochondrial

Wt: 174.9
BDBM50350311
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Wt: 286.1
BDBM50427900
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Wt: 174.9
BDBM50427901
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50350311,50427900,50427901   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
PDB
MMDB

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8.5n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 2


J Med Chem 54: 5432-43 (2011)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427901
PNG
(CHEMBL2326088)
Show SMILES N[C@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m1/s1
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n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427900
PNG
((R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]he...)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
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n/an/a 509n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
PDB
MMDB

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PubMed
n/an/a 2.15E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
PDB
MMDB

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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/a 1.92E+3n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)

More data for this
Ligand-Target Pair