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There are 27 purchasable compounds for target: LB24-AB

Compile data set for download or QSAR
Wt: 228.2
BDBM23926
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Wt: 142.1
BDBM50031467
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Wt: 266.2
BDBM50067044
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Wt: 238.2
BDBM50096003
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Wt: 244.2
BDBM50108046
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Wt: 300.3
BDBM50108052
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Wt: 148.2
BDBM50139366
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Wt: 122.1
BDBM50139367
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Wt: 152.1
BDBM50139368
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Wt: 164.2
BDBM50139369
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Wt: 136.1
BDBM50139370
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Wt: 887.0
BDBM50176700
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Wt: 784.9
BDBM50176701
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Wt: 162.1
BDBM50174558
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Wt: 198.1
BDBM50198715
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Displayed 1 to 15 (of 26 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 23926,50031467,50067044,50096003,50108046,50108052,50139366,50139367,50139368,50139369,50139370,50176700,50176701,50174558,50198715   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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PubMed
3.50E+5n/an/an/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.25E+5n/an/an/an/an/an/a



National Cheng Kung University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Nat Prod 66: 990-3 (2003)


Article DOI: 10.1021/np030054x
BindingDB Entry DOI: 10.7270/Q20P0ZSD
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.25E+5n/an/an/an/an/an/a



National Cheng Kung University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin)


J Nat Prod 66: 1207-11 (2003)


Article DOI: 10.1021/np030034v
BindingDB Entry DOI: 10.7270/Q2R49QHN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139366
PNG
(4-Isopropyl-benzaldehyde | 4-isopropylbenzaldehyde...)
Show SMILES CC(C)c1ccc(C=O)cc1
Show InChI InChI=1S/C10H12O/c1-8(2)10-5-3-9(7-11)4-6-10/h3-8H,1-2H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139367
PNG
(2-hydroxybenzaldehyde | CHEMBL108925 | Salicylalde...)
Show SMILES Oc1ccccc1C=O
Show InChI InChI=1S/C7H6O2/c8-5-6-3-1-2-4-7(6)9/h1-5,9H
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n/an/a 3.30E+6n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139368
PNG
(2-Hydroxy-4-methoxy-benzaldehyde | 2-hydroxy-4-met...)
Show SMILES COc1ccc(C=O)c(O)c1
Show InChI InChI=1S/C8H8O3/c1-11-7-3-2-6(5-9)8(10)4-7/h2-5,10H,1H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139369
PNG
(2-Hydroxy-4-isopropyl-benzaldehyde | CHEMBL353354)
Show SMILES CC(C)c1ccc(C=O)c(O)c1
Show InChI InChI=1S/C10H12O2/c1-7(2)8-3-4-9(6-11)10(12)5-8/h3-7,12H,1-2H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50139370
PNG
(4-Methoxy-benzaldehyde | 4-methoxybenzaldehyde | C...)
Show SMILES COc1ccc(C=O)cc1
Show InChI InChI=1S/C8H8O2/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3
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n/an/a 3.20E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was evaluated against the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroom tyrosinase


Bioorg Med Chem Lett 14: 681-3 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.033
BindingDB Entry DOI: 10.7270/Q27S7N6X
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.29E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase


Bioorg Med Chem Lett 14: 2843-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.046
BindingDB Entry DOI: 10.7270/Q2N015ZH
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50108052
PNG
(1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxy...)
Show SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)c(OC)c1
Show InChI InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 16: 5650-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.018
BindingDB Entry DOI: 10.7270/Q2348K00
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.33E+5n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 16: 5650-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.018
BindingDB Entry DOI: 10.7270/Q2348K00
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50108046
PNG
((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)c(O)c1
Show InChI InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+
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n/an/a 1.27E+4n/an/an/an/an/an/a



Chulalongkorn University

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 16: 5650-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.018
BindingDB Entry DOI: 10.7270/Q2348K00
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 9.15E+3n/an/an/an/an/an/a



Tokyo University of Agriculture and Technology

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis


Bioorg Med Chem 23: 6650-8 (2015)


Article DOI: 10.1016/j.bmc.2015.09.014
BindingDB Entry DOI: 10.7270/Q2DR2X9W
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 5.71E+5n/an/an/an/an/an/a



Institute for Theoretical Medicine, Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometry


Bioorg Med Chem 22: 6193-200 (2014)


Article DOI: 10.1016/j.bmc.2014.08.027
BindingDB Entry DOI: 10.7270/Q2DV1MG2
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 6.66E+4n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Eur J Med Chem 44: 3195-200 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.020
BindingDB Entry DOI: 10.7270/Q29S1R35
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50067044
PNG
((1E,4E)-1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-...)
Show SMILES Oc1ccc(\C=C\C(=O)\C=C\c2ccc(O)cc2)cc1
Show InChI InChI=1S/C17H14O3/c18-15-7-1-13(2-8-15)5-11-17(20)12-6-14-3-9-16(19)10-4-14/h1-12,18-19H/b11-5+,12-6+
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n/an/a 7.91E+4n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Eur J Med Chem 44: 3195-200 (2009)


Article DOI: 10.1016/j.ejmech.2009.03.020
BindingDB Entry DOI: 10.7270/Q29S1R35
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



Utsunomiya University

Curated by ChEMBL


Assay Description
Inhibition of Tyrosinase


Eur J Med Chem 46: 1374-81 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.065
BindingDB Entry DOI: 10.7270/Q20V8D41
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/a 3.68E+6n/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 21: 3342-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.012
BindingDB Entry DOI: 10.7270/Q2QF8T68
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50174558
PNG
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Show SMILES Oc1ccc2ccc(=O)oc2c1
Show InChI InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
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n/an/a 4.20E+5n/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 21: 3342-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.012
BindingDB Entry DOI: 10.7270/Q2QF8T68
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50096003
PNG
(7-Hydroxy-3-phenyl-chromen-2-one | 7-hydroxy-3-phe...)
Show SMILES Oc1ccc2cc(-c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C15H10O3/c16-12-7-6-11-8-13(10-4-2-1-3-5-10)15(17)18-14(11)9-12/h1-9,16H
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n/an/a>1.00E+7n/an/an/an/an/an/a



Universidad de Santiago de Compostela

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase


Bioorg Med Chem Lett 21: 3342-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.012
BindingDB Entry DOI: 10.7270/Q2QF8T68
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.29E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of tyrosinase enzyme.


Bioorg Med Chem Lett 6: 1303-1308 (1996)


Article DOI: 10.1016/0960-894X(96)00221-1
BindingDB Entry DOI: 10.7270/Q2V1259K
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.80E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity against mushroom tyrosinase (approximate value given)


Bioorg Med Chem Lett 13: 2409-12 (2003)


Article DOI: 10.1016/s0960-894x(03)00395-0
BindingDB Entry DOI: 10.7270/Q2HD7W6H
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Bioorg Med Chem Lett 16: 324-30 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.085
BindingDB Entry DOI: 10.7270/Q2S75H42
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50176700
PNG
(CHEMBL371147 | askendoside D)
Show SMILES CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)[C@@H]3C[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O)C4(C)C
Show InChI InChI=1S/C45H74O17/c1-39(2)26(60-38-33(30(52)23(49)18-58-38)61-37-32(54)29(51)22(48)17-57-37)9-11-45-19-44(45)13-12-41(5)34(43(7)10-8-27(62-43)40(3,4)55)20(46)15-42(41,6)25(44)14-24(35(39)45)59-36-31(53)28(50)21(47)16-56-36/h20-38,46-55H,8-19H2,1-7H3/t20-,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34-,35-,36-,37-,38-,41+,42-,43+,44-,45+/m0/s1
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n/an/a 4.89E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Bioorg Med Chem Lett 16: 324-30 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.085
BindingDB Entry DOI: 10.7270/Q2S75H42
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50176701
PNG
(CHEMBL378140 | cyclosieversioside)
Show SMILES CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]1[C@@H](O)C[C@@]2(C)[C@@H]3C[C@H](O[C@H]4O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]4O)[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)C4(C)C
Show InChI InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30-,31-,32-,33-,34-,37+,38-,39+,40-,41+/m0/s1
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n/an/a 9.23E+4n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibitory activity against tyrosinase


Bioorg Med Chem Lett 16: 324-30 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.085
BindingDB Entry DOI: 10.7270/Q2S75H42
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.50E+7n/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in human MNT1 cells assessed as suppression of melanin biosynthesis measured after 96 hrs


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 2.80E+6n/an/an/an/an/an/a



Univ. Grenoble-Alpes/CNRS

Curated by ChEMBL


Assay Description
Inhibition of tyrosinase in human MNT1 cell lysate pretreated prior to addition of L-DOPA as substrate measured after 3 hrs


ACS Med Chem Lett 8: 55-60 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00369
BindingDB Entry DOI: 10.7270/Q24F1SQN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
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n/an/a 3.68E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 23926,50031467,50067044,50096003,50108046,50108052,50139366,50139367,50139368,50139369,50139370,50176700,50176701,50174558,50198715
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
Quinone Reductase 2 (QR2)

(Homo sapiens (Human))
BDBM23926
JPEG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
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-9.785.00-14.67.417.525



University of Illinois at Chicago





Biochem J 413: 81-91 (2008)