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There are 51 purchasable compounds for target: Apurinic-apyrimidinic endonuclease 1 (APE-1)

Wt: 294.3
BDBM26581
Purchase
Wt: 250.2
BDBM26582
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Wt: 275.2
BDBM26589
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Wt: 307.7
BDBM26576
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Wt: 239.2
BDBM26596
Wt: 287.3
BDBM26597
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Wt: 291.2
BDBM26598
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Wt: 458.4
BDBM26599
Wt: 442.3
BDBM26600
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Wt: 378.3
BDBM26601
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Wt: 468.5
BDBM26602
Purchase
Wt: 455.4
BDBM26603
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Wt: 475.3
BDBM26604
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Wt: 320.3
BDBM26605
Purchase
Wt: 370.4
BDBM26606
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Displayed 1 to 15 (of 51 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 26581,26582,26589,26576,26596,26597,26598,26599,26600,26601,26602,26603,26604,26605,26606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26576
PNG
(3-[1-(carboxymethyl)-5-(4-chlorophenyl)-1H-pyrrol-...)
Show SMILES OC(=O)CCc1ccc(-c2ccc(Cl)cc2)n1CC(O)=O
Show InChI InChI=1S/C15H14ClNO4/c16-11-3-1-10(2-4-11)13-7-5-12(6-8-14(18)19)17(13)9-15(20)21/h1-5,7H,6,8-9H2,(H,18,19)(H,20,21)
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PubMed
n/an/a 4.00E+3n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26606
PNG
(5-{[(2-{[(4-carboxy-5-methylfuran-2-yl)methyl]sulf...)
Show SMILES Cc1oc(CSCCSCc2cc(C(O)=O)c(C)o2)cc1C(O)=O
Show InChI InChI=1S/C16H18O6S2/c1-9-13(15(17)18)5-11(21-9)7-23-3-4-24-8-12-6-14(16(19)20)10(2)22-12/h5-6H,3-4,7-8H2,1-2H3,(H,17,18)(H,19,20)
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UniChem
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PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26582
PNG
(2-[3-(carboxymethyl)-2-oxo-2,3-dihydro-1H-1,3-benz...)
Show SMILES OC(=O)Cn1c2ccccc2n(CC(O)=O)c1=O
Show InChI InChI=1S/C11H10N2O5/c14-9(15)5-12-7-3-1-2-4-8(7)13(11(12)18)6-10(16)17/h1-4H,5-6H2,(H,14,15)(H,16,17)
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PubMed
n/an/a 1.60E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26589
PNG
(3-(2-carboxyethyl)-4-hydroxy-2-methylquinoline-6-c...)
Show SMILES Cc1nc2ccc(cc2c(O)c1CCC(O)=O)C(O)=O
Show InChI InChI=1S/C14H13NO5/c1-7-9(3-5-12(16)17)13(18)10-6-8(14(19)20)2-4-11(10)15-7/h2,4,6H,3,5H2,1H3,(H,15,18)(H,16,17)(H,19,20)
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n/an/a 2.00E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26596
PNG
(3-[(6-amino-9H-purin-8-yl)sulfanyl]propanoic acid ...)
Show SMILES Nc1ncnc2nc(SCCC(O)=O)[nH]c12
Show InChI InChI=1S/C8H9N5O2S/c9-6-5-7(11-3-10-6)13-8(12-5)16-2-1-4(14)15/h3H,1-2H2,(H,14,15)(H3,9,10,11,12,13)
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n/an/a 2.00E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26597
PNG
(3-[1-(carboxymethyl)-5-(4-methylphenyl)-1H-pyrrol-...)
Show SMILES Cc1ccc(cc1)-c1ccc(CCC(O)=O)n1CC(O)=O
Show InChI InChI=1S/C16H17NO4/c1-11-2-4-12(5-3-11)14-8-6-13(7-9-15(18)19)17(14)10-16(20)21/h2-6,8H,7,9-10H2,1H3,(H,18,19)(H,20,21)
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PubMed
n/an/a 1.20E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26598
PNG
(3-[1-(carboxymethyl)-5-(4-fluorophenyl)-1H-pyrrol-...)
Show SMILES OC(=O)CCc1ccc(-c2ccc(F)cc2)n1CC(O)=O
Show InChI InChI=1S/C15H14FNO4/c16-11-3-1-10(2-4-11)13-7-5-12(6-8-14(18)19)17(13)9-15(20)21/h1-5,7H,6,8-9H2,(H,18,19)(H,20,21)
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PubMed
n/an/a 9.00E+3n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26599
PNG
(4-({4-[(4-carboxybenzene)sulfonyl]phenyl}sulfanyl)...)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)c1ccc(Sc2ccc(C(O)=O)c(c2)C(O)=O)cc1
Show InChI InChI=1S/C21H14O8S2/c22-19(23)12-1-6-15(7-2-12)31(28,29)16-8-3-13(4-9-16)30-14-5-10-17(20(24)25)18(11-14)21(26)27/h1-11H,(H,22,23)(H,24,25)(H,26,27)
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n/an/a 6.00E+3n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26600
PNG
(4-{[4-(4-carboxyphenoxy)benzene]sulfonyl}benzene-1...)
Show SMILES OC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccc(C(O)=O)c(c2)C(O)=O)cc1
Show InChI InChI=1S/C21H14O9S/c22-19(23)12-1-3-13(4-2-12)30-14-5-7-15(8-6-14)31(28,29)16-9-10-17(20(24)25)18(11-16)21(26)27/h1-11H,(H,22,23)(H,24,25)(H,26,27)
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n/an/a 1.00E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26601
PNG
(2-{3-[(5Z)-3-(carboxymethyl)-4-oxo-2-sulfanylidene...)
Show SMILES OC(=O)CN1C(=S)S\C(C1=O)=C1/C(=O)N(CC(O)=O)c2ccccc12
Show InChI InChI=1S/C15H10N2O6S2/c18-9(19)5-16-8-4-2-1-3-7(8)11(13(16)22)12-14(23)17(6-10(20)21)15(24)25-12/h1-4H,5-6H2,(H,18,19)(H,20,21)/b12-11-
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26602
PNG
(2-{5-[(3Z)-1-(carboxymethyl)-2-oxo-2,3-dihydro-1H-...)
Show SMILES OC(=O)CN1C(=O)\C(=C2/SC(=S)N(C(Cc3ccccc3)C(O)=O)C2=O)c2ccccc12
Show InChI InChI=1S/C22H16N2O6S2/c25-16(26)11-23-14-9-5-4-8-13(14)17(19(23)27)18-20(28)24(22(31)32-18)15(21(29)30)10-12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H,25,26)(H,29,30)/b18-17-
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26603
PNG
(2-{3-[(5Z)-3-[(2-hydroxybenzene)amido]-4-oxo-2-sul...)
Show SMILES OC(=O)CN1C(=O)\C(=C2/SC(=S)N(NC(=O)c3ccccc3O)C2=O)c2ccccc12
Show InChI InChI=1S/C20H13N3O6S2/c24-13-8-4-2-6-11(13)17(27)21-23-19(29)16(31-20(23)30)15-10-5-1-3-7-12(10)22(18(15)28)9-14(25)26/h1-8,24H,9H2,(H,21,27)(H,25,26)/b16-15-
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26604
PNG
(2-{3-[(5Z)-3-(4-bromophenyl)-4-oxo-2-sulfanylidene...)
Show SMILES OC(=O)CN1C(=O)\C(=C2/SC(=S)N(C2=O)c2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C19H11BrN2O4S2/c20-10-5-7-11(8-6-10)22-18(26)16(28-19(22)27)15-12-3-1-2-4-13(12)21(17(15)25)9-14(23)24/h1-8H,9H2,(H,23,24)/b16-15-
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PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26605
PNG
(2-{2-oxo-3-[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazol...)
Show SMILES OC(=O)CN1C(=O)\C(=C2/SC(=S)NC2=O)c2ccccc12
Show InChI InChI=1S/C13H8N2O4S2/c16-8(17)5-15-7-4-2-1-3-6(7)9(12(15)19)10-11(18)14-13(20)21-10/h1-4H,5H2,(H,16,17)(H,14,18,20)/b10-9-
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PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair
Apurinic-apyrimidinic endonuclease 1 (APE-1)


(Homo sapiens (Human))
BDBM26581
PNG
(3-[3-(2-carboxyethyl)-2-sulfanylidene-2,3-dihydro-...)
Show SMILES OC(=O)CCn1c2ccccc2n(CCC(O)=O)c1=S
Show InChI InChI=1S/C13H14N2O4S/c16-11(17)5-7-14-9-3-1-2-4-10(9)15(13(14)20)8-6-12(18)19/h1-4H,5-8H2,(H,16,17)(H,18,19)
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n/an/a 1.50E+4n/an/an/an/a7.530



University of Southern California



Assay Description
To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,...


J Med Chem 52: 20-32 (2009)

More data for this
Ligand-Target Pair