Found 29 hits for monomerid = 7460,16173,21398,22165,25870,25749,25752,25753,25392,25755,25756,25758,25759,25761,25762 Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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| 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25759
 (CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)Show SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 Show InChI InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 | Reactome pathway KEGG
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| Article PubMed
| 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rzeszów University of Technology
Curated by ChEMBL
| Assay Description Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method |
Eur J Med Chem 44: 809-17 (2009)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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| | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Medical University of Warsaw
| Assay Description Radioligand receptor binding studies were conducted in the rat brain. |
Medicinal Chemistry Research 17: 507-514 (2008)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25758
 (2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amin...)Show InChI InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24) | Reactome pathway KEGG
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Patents AffyNet 
| PubMed
| 12.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25752
 (Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)Show InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1 | Reactome pathway KEGG
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| 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25756
 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 | Reactome pathway KEGG
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| 63.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25392
 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain |
J Med Chem 35: 1009-18 (1992)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25392
 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand |
J Med Chem 36: 3077-86 (1993)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
| PubMed
| 81.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25753
 (2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl...)Show InChI InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) | Reactome pathway KEGG
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Similars AffyNet 
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| 97.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25755
 (Acebutolol | Acetobutolol | N-{3-acetyl-4-[2-hydro...)Show InChI InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23) | Reactome pathway KEGG
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Similars AffyNet 
| PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25749
 (CHEMBL6995 | N-{4-[2-hydroxy-3-(propan-2-ylamino)p...)Show InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17) | Reactome pathway KEGG
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| 245 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25392
 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of binding of [3H]-dihydroalprenolol from beta-1 adrenergic receptor of rat cerebral cortical membranes |
J Med Chem 34: 1063-8 (1991)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25762
 (CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)et...)Show InChI InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 | Reactome pathway KEGG
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Similars AffyNet 
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| 2.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
| Article PubMed
| 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting |
Bioorg Med Chem 17: 1345-52 (2009)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM7460
 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Westfälische Wilhelms-Universitä Muenster,
Curated by PDSP Ki Database
| |
Psychopharmacology (Berl) 162: 193-202 (2002)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM16173
 (3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | Reactome pathway KEGG
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Similars AffyNet 
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by PDSP Ki Database
| |
J Recept Res 11: 891-907 (1991)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25870
 (1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Industri A/S
Curated by PDSP Ki Database
| |
Eur J Pharmacol 166: 493-504 (1989)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM22165
 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 | Reactome pathway KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Industri A/S
Curated by PDSP Ki Database
| |
Eur J Pharmacol 166: 493-504 (1989)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM21398
 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-DHA |
J Med Chem 29: 1628-37 (1986)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
| Article PubMed
| n/a | n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a |
University of Grenoble
Curated by ChEMBL
| Assay Description Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer) |
J Med Chem 41: 1613-8 (1998)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a |
University of Grenoble
Curated by ChEMBL
| Assay Description Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer) |
J Med Chem 41: 1613-8 (1998)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria |
J Med Chem 30: 1003-11 (1987)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25756
 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria |
J Med Chem 30: 1003-11 (1987)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25392
 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company
Curated by ChEMBL
| Assay Description Compound was evaluated in vitro for beta-adrenergic activity against beta-1 adrenergic receptor by the inhibition of insulin stimulated [14C]- glucos... |
J Med Chem 35: 3081-4 (1992)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25761
 (Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | Reactome pathway KEGG
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Similars AffyNet 
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| n/a | n/a | n/a | 4.37 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria |
J Med Chem 30: 1003-11 (1987)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25752
 (Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)Show InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet 
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PC cid PC sid UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria |
J Med Chem 30: 1003-11 (1987)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25756
 ((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet 
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | n/a | 22.9 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria |
J Med Chem 30: 1003-11 (1987)
|
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Rattus norvegicus (Rat)) | BDBM25392
 (4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet 
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
American Cyanamid Company
Curated by ChEMBL
| Assay Description Compound was evaluated for its binding affinity towards beta-1 adrenergic receptor in rat heart membrane by displacing [125I]- iodocyanopindolol |
J Med Chem 35: 3081-4 (1992)
|
More data for this Ligand-Target Pair | |