Found 9 hits for monomerid = 50324539,50386292,50386309,50386312,50386313 Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386292
 (CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
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CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysis |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386292
 (CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
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CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysis |
Bioorg Med Chem Lett 23: 1961-6 (2013)
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386312
 (CHEMBL2049094)Show InChI InChI=1S/C10H12N2O2/c1-6-2-3-9-7(4-6)5-8(11)10(13)12(9)14/h2-4,8,14H,5,11H2,1H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386313
 (CHEMBL2047850)Show InChI InChI=1S/C9H10N2O/c10-7-5-6-3-1-2-4-8(6)11-9(7)12/h1-4,7H,5,10H2,(H,11,12)/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386292
 (CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386309
 (CHEMBL2047862)Show InChI InChI=1S/C10H12N2O2/c1-6-2-3-7-5-8(11)10(13)12(14)9(7)4-6/h2-4,8,14H,5,11H2,1H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50324539
 ((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars AffyNet 
| MMDB Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Piemonte Orientale Amedeo Avogadro
Curated by ChEMBL
| Assay Description Inhibition of KAT2 in human prefrontal cortex homogenates |
J Med Chem 53: 5684-9 (2010)
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50386292
 (CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human KAT2 using L-kynurenine as substrate measured after 15-20 hrs by SpectraMax plate reader analysis |
Citation and Details
|
More data for this Ligand-Target Pair | |
Kynurenine aminotransferase II (KAT II)
(Homo sapiens (Human)) | BDBM50324539
 ((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars AffyNet 
| MMDB Article PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Piemonte Orientale Amedeo Avogadro
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MBP-KAT2 expressed in HEK293 cells assessed as conversion of L-kynurenine to kynurenic acid after 1 hr |
J Med Chem 53: 5684-9 (2010)
|
More data for this Ligand-Target Pair | |