Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386292 (CHEMBL2047851) Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Irreversible inhibition of human KAT2 using L-kynurenine as substrate measured every 5 mins over 16 hrs by SpectraMax plate reader analysis				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386292 (CHEMBL2047851) Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human KAT2 using L-kynurenine as substrate after 15 to 20 hrs by UV-visible spectra analysis				Bioorg Med Chem Lett 23: 1961-6 (2013)
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386312 (CHEMBL2049094) Show SMILES Cc1ccc2N(O)C(=O)[C@@H](N)Cc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386313 (CHEMBL2047850) Show SMILES N[C@H]1Cc2ccccc2NC1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386292 (CHEMBL2047851) Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386309 (CHEMBL2047862) Show SMILES Cc1ccc2C[C@H](N)C(=O)N(O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrs				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50324539 ((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars AffyNet	MMDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Piemonte Orientale Amedeo Avogadro Curated by ChEMBL					Assay Description Inhibition of KAT2 in human prefrontal cortex homogenates				J Med Chem 53: 5684-9 (2010)
					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50386292 (CHEMBL2047851) Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet	Article	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human KAT2 using L-kynurenine as substrate measured after 15-20 hrs by SpectraMax plate reader analysis				Citation and Details
TBA					More data for this Ligand-Target Pair
Kynurenine aminotransferase II (KAT II) (Homo sapiens (Human))	BDBM50324539 ((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars AffyNet	MMDB Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
University of Piemonte Orientale Amedeo Avogadro Curated by ChEMBL					Assay Description Inhibition of human recombinant MBP-KAT2 expressed in HEK293 cells assessed as conversion of L-kynurenine to kynurenic acid after 1 hr				J Med Chem 53: 5684-9 (2010)
					More data for this Ligand-Target Pair

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB