Wt: 163.1 BDBM18351 ![]() | Wt: 163.1 BDBM113762 ![]() | Wt: 163.1 BDBM50163439 ![]() | Wt: 163.1 BDBM50163440 ![]() | Wt: 163.1 BDBM50163441 ![]() |
Wt: 163.1 BDBM50163443 ![]() | Wt: 133.1 BDBM50182798 ![]() | Wt: 163.1 BDBM50241865 ![]() |
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50241865![]() (2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Competitive inhibition of human lysosome alpha-galactosidase by Lineweaver-Burk plot analysis | Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM18351![]() ((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars | MMDB Article PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hamburg Curated by ChEMBL | Assay Description Compound tested for inhibition of alpha-galactosidase from Aspergillus niger | Bioorg Med Chem Lett 14: 73-5 (2003) Article DOI: 10.1016/j.bmcl.2003.10.011 BindingDB Entry DOI: 10.7270/Q2JM2925 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50182798![]() ((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for inhibition of alpha-galactosidase from green coffee beans (sigma G 8507). | Bioorg Med Chem Lett 6: 553-558 (1996) Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50241865![]() (2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis | Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama Curated by ChEMBL | Assay Description Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis | Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM113762![]() (1-Deoxygalactonojirimycin (DGJ) | 2-(hydroxymethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 5.0 | n/a |
Tottori University , Yonago 683-8503, Japan | Assay Description For inhibition assay, 0.1% Triton X-100 extracts were mixed with 4-MU substrates ( 5 mM 4-MU α-ᴅ-galactopyranoside and 0.1 M N-acetyl-J... | ACS Chem Biol 9: 1460-9 (2014) Article DOI: 10.1021/cb500143h BindingDB Entry DOI: 10.7270/Q2XS5T16 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against human alpha-galactosidase | J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50163443![]() ((2R,3S,4S,5S)-2-Hydroxymethyl-piperidine-3,4,5-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against human alpha-galactosidase | J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50163441![]() ((2R,3S,4S,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against human alpha-galactosidase | J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM50163439![]() ((2S,3R,4S,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against human alpha-galactosidase | J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-galactosidase A (Homo sapiens (Human)) | BDBM50241865![]() (2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cheng-Kung University Curated by ChEMBL | Assay Description Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc... | Eur J Med Chem 123: 14-20 (2016) Article DOI: 10.1016/j.ejmech.2016.07.025 BindingDB Entry DOI: 10.7270/Q2RB76KN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human)) | BDBM113762![]() (1-Deoxygalactonojirimycin (DGJ) | 2-(hydroxymethyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Tottori University , Yonago 683-8503, Japan | Assay Description For inhibition assay, 0.1% Triton X-100 extracts were mixed with 4-MU substrates ( 5 mM 4-MU α-ᴅ-galactopyranoside and 0.1 M N-acetyl-J... | ACS Chem Biol 9: 1460-9 (2014) Article DOI: 10.1021/cb500143h BindingDB Entry DOI: 10.7270/Q2XS5T16 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-galactosidase A (Homo sapiens (Human)) | BDBM50241865![]() (2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cheng-Kung University Curated by ChEMBL | Assay Description Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore... | Eur J Med Chem 123: 14-20 (2016) Article DOI: 10.1016/j.ejmech.2016.07.025 BindingDB Entry DOI: 10.7270/Q2RB76KN | |||||||||||
More data for this Ligand-Target Pair |