Compounds in cluster

There are 8 purchasable compounds for target: Alpha-glucosidase A (?-Gal A)

Wt: 163.1 BDBM18351 Purchase	Wt: 163.1 BDBM113762 Purchase	Wt: 163.1 BDBM50163439 Purchase	Wt: 163.1 BDBM50163440 Purchase	Wt: 163.1 BDBM50163441 Purchase
Wt: 163.1 BDBM50163443 Purchase	Wt: 133.1 BDBM50182798 Purchase	Wt: 163.1 BDBM50241865 Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 18351,113762,50163439,50163440,50163441,50163443,50182798,50241865
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50241865 (2,5-dideoxy-2,5-imino-D-altritol \| 2R,5R-dihydroxy...) Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Competitive inhibition of human lysosome alpha-galactosidase by Lineweaver-Burk plot analysis				Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM18351 ((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...) Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	MMDB Article PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Hamburg Curated by ChEMBL					Assay Description Compound tested for inhibition of alpha-galactosidase from Aspergillus niger				Bioorg Med Chem Lett 14: 73-5 (2003) Article DOI: 10.1016/j.bmcl.2003.10.011 BindingDB Entry DOI: 10.7270/Q2JM2925
University of Hamburg Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50182798 ((3R,4r,5S)-piperidine-3,4,5-triol \| 1,5-Dideoxy-1,...) Show SMILES O[C@H]1CNC[C@@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for inhibition of alpha-galactosidase from green coffee beans (sigma G 8507).				Bioorg Med Chem Lett 6: 553-558 (1996) Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50241865 (2,5-dideoxy-2,5-imino-D-altritol \| 2R,5R-dihydroxy...) Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis				Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50163440 ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis				Bioorg Med Chem 18: 3790-4 (2010) Article DOI: 10.1016/j.bmc.2010.04.048 BindingDB Entry DOI: 10.7270/Q2XK8FQP
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM113762 (1-Deoxygalactonojirimycin (DGJ) \| 2-(hydroxymethyl...) Show SMILES OCC1NCC(O)C(O)C1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	5.0	n/a
Tottori University , Yonago 683-8503, Japan					Assay Description For inhibition assay, 0.1% Triton X-100 extracts were mixed with 4-MU substrates ( 5 mM 4-MU α-ᴅ-galactopyranoside and 0.1 M N-acetyl-J...				ACS Chem Biol 9: 1460-9 (2014) Article DOI: 10.1021/cb500143h BindingDB Entry DOI: 10.7270/Q2XS5T16
Tottori University , Yonago 683-8503, Japan					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50163440 ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against human alpha-galactosidase				J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M
					More data for this Ligand-Target Pair				3D Structure (crystal)
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50163443 ((2R,3S,4S,5S)-2-Hydroxymethyl-piperidine-3,4,5-tri...) Show SMILES OC[C@H]1NC[C@H](O)[C@H](O)[C@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against human alpha-galactosidase				J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M
					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50163441 ((2R,3S,4S,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...) Show SMILES OC[C@H]1NC[C@@H](O)[C@H](O)[C@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against human alpha-galactosidase				J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M
					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM50163439 ((2S,3R,4S,5R)-2-Hydroxymethyl-piperidine-3,4,5-tri...) Show SMILES OC[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Toyama Medical and Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against human alpha-galactosidase				J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M
					More data for this Ligand-Target Pair
Alpha-galactosidase A (Homo sapiens (Human))	BDBM50241865 (2,5-dideoxy-2,5-imino-D-altritol \| 2R,5R-dihydroxy...) Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
National Cheng-Kung University Curated by ChEMBL					Assay Description Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...				Eur J Med Chem 123: 14-20 (2016) Article DOI: 10.1016/j.ejmech.2016.07.025 BindingDB Entry DOI: 10.7270/Q2RB76KN
National Cheng-Kung University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase A (α-Gal A) (Homo sapiens (Human))	BDBM113762 (1-Deoxygalactonojirimycin (DGJ) \| 2-(hydroxymethyl...) Show SMILES OCC1NCC(O)C(O)C1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.780	n/a	n/a	n/a	n/a	7.0	n/a
Tottori University , Yonago 683-8503, Japan					Assay Description For inhibition assay, 0.1% Triton X-100 extracts were mixed with 4-MU substrates ( 5 mM 4-MU α-ᴅ-galactopyranoside and 0.1 M N-acetyl-J...				ACS Chem Biol 9: 1460-9 (2014) Article DOI: 10.1021/cb500143h BindingDB Entry DOI: 10.7270/Q2XS5T16
Tottori University , Yonago 683-8503, Japan					More data for this Ligand-Target Pair
Alpha-galactosidase A (Homo sapiens (Human))	BDBM50241865 (2,5-dideoxy-2,5-imino-D-altritol \| 2R,5R-dihydroxy...) Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cheng-Kung University Curated by ChEMBL					Assay Description Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...				Eur J Med Chem 123: 14-20 (2016) Article DOI: 10.1016/j.ejmech.2016.07.025 BindingDB Entry DOI: 10.7270/Q2RB76KN
National Cheng-Kung University Curated by ChEMBL					More data for this Ligand-Target Pair