Wt: 264.3 BDBM19149 ![]() | Wt: 376.4 BDBM19410 ![]() | Wt: 351.4 BDBM19423 ![]() | Wt: 379.4 BDBM19428 ![]() | Wt: 302.3 BDBM19130 ![]() |
Wt: 721.8 BDBM22449 ![]() | Wt: 396.4 BDBM24624 ![]() | Wt: 318.3 BDBM25150 ![]() | Wt: 88.1 BDBM26109 ![]() | Wt: 349.4 BDBM29589 ![]() |
Wt: 557.6 BDBM36483 ![]() | Wt: 163.1 BDBM36184 ![]() | Wt: 292.3 BDBM55151 ![]() | Wt: 303.3 BDBM96613 ![]() | Wt: 302.3 BDBM50005711 ![]() |
Displayed 1 to 15 (of 41 total ) | Next | Last >> |
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM29589![]() (Faridak | LBH-589 | LBH-589B | Panobinostat) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
S*BIO Pte Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay | J Med Chem 54: 4694-720 (2011) Article DOI: 10.1021/jm2003552 BindingDB Entry DOI: 10.7270/Q29S1RD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM25150![]() ((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
S*BIO Pte Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay | J Med Chem 54: 4694-720 (2011) Article DOI: 10.1021/jm2003552 BindingDB Entry DOI: 10.7270/Q29S1RD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
S *BIO Pte Ltd Curated by ChEMBL | Assay Description Inhibition of HDAC5 | Bioorg Med Chem Lett 20: 3314-21 (2010) Article DOI: 10.1016/j.bmcl.2010.04.041 BindingDB Entry DOI: 10.7270/Q2GT5NCX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
S*BIO Pte Ltd. Curated by ChEMBL | Assay Description Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay | J Med Chem 54: 4694-720 (2011) Article DOI: 10.1021/jm2003552 BindingDB Entry DOI: 10.7270/Q29S1RD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM29589![]() (Faridak | LBH-589 | LBH-589B | Panobinostat) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem 23: 5151-5 (2015) Article DOI: 10.1016/j.bmc.2014.12.066 BindingDB Entry DOI: 10.7270/Q2B859V9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM25150![]() ((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 175 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem 23: 5151-5 (2015) Article DOI: 10.1016/j.bmc.2014.12.066 BindingDB Entry DOI: 10.7270/Q2B859V9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid PDB UniChem | Article PubMed | 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem 23: 5151-5 (2015) Article DOI: 10.1016/j.bmc.2014.12.066 BindingDB Entry DOI: 10.7270/Q2B859V9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19428![]() ((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem 23: 5151-5 (2015) Article DOI: 10.1016/j.bmc.2014.12.066 BindingDB Entry DOI: 10.7270/Q2B859V9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM22449![]() (CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St Jude Children's Research Hospital Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem 23: 5151-5 (2015) Article DOI: 10.1016/j.bmc.2014.12.066 BindingDB Entry DOI: 10.7270/Q2B859V9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM24624![]() (CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 37 |
MethylGene Inc. | Assay Description The HDAC enzyme in vitro assay was based on a homogeneous fluorescence release assay. Purified recombinant HDAC enzymes were incubated with compounds... | J Med Chem 51: 4072-5 (2008) Article DOI: 10.1021/jm800251w BindingDB Entry DOI: 10.7270/Q28P5XTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM/Merck | Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc... | J Med Chem 51: 2350-3 (2008) Article DOI: 10.1021/jm800079s BindingDB Entry DOI: 10.7270/Q2W957H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19410![]() (CHEMBL27759 | MS-275 | US9265734, MS-275 | benzami...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM/Merck | Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc... | J Med Chem 51: 2350-3 (2008) Article DOI: 10.1021/jm800079s BindingDB Entry DOI: 10.7270/Q2W957H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM36483![]() ((S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpent...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.04E+3 | n/a | n/a | n/a | n/a | 7.4 | 0 |
Dana-Farber Cancer Institute | Assay Description For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add... | Nat Chem Biol 6: 238-243 (2010) Article DOI: 10.1038/nchembio.313 BindingDB Entry DOI: 10.7270/Q2C53J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM29589![]() (Faridak | LBH-589 | LBH-589B | Panobinostat) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of Harvard and MIT | Assay Description Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ... | ACS Chem Biol 11: 363-74 (2016) Article DOI: 10.1021/acschembio.5b00640 BindingDB Entry DOI: 10.7270/Q2BZ64T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of Harvard and MIT | Assay Description Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ... | ACS Chem Biol 11: 363-74 (2016) Article DOI: 10.1021/acschembio.5b00640 BindingDB Entry DOI: 10.7270/Q2BZ64T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid PDB UniChem | n/a | n/a | 12.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
BIOMARIN PHARMACEUTICAL INC. US Patent | Assay Description HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48... | US Patent US9265734 (2016) BindingDB Entry DOI: 10.7270/Q2BK1B5B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University | Assay Description Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ... | ACS Chem Biol 12: 254-264 (2017) Article DOI: 10.1021/acschembio.6b00776 BindingDB Entry DOI: 10.7270/Q23R0RQN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19423![]() (HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University | Assay Description Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ... | ACS Chem Biol 12: 254-264 (2017) Article DOI: 10.1021/acschembio.6b00776 BindingDB Entry DOI: 10.7270/Q23R0RQN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM22449![]() (CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; THE CHILDREN'S HOSPITAL OF PHILADELPHIA US Patent | Assay Description HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC... | US Patent US9249087 (2016) BindingDB Entry DOI: 10.7270/Q2Q23Z3W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Soochow University | Assay Description Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%... | J Biol Chem 288: 34181-9 (2013) Article DOI: 10.1074/jbc.M113.472563 BindingDB Entry DOI: 10.7270/Q2668C1K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19410![]() (CHEMBL27759 | MS-275 | US9265734, MS-275 | benzami...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. | Assay Description Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19423![]() (HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. | Assay Description Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 871 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. | Assay Description Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. | Assay Description Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of HDAC5 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate by fluorescence assay | Citation and Details Article DOI: 10.1021/ml400175d BindingDB Entry DOI: 10.7270/Q2CZ38KR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Inhibition of human recombinant HDAC5 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins | J Med Chem 54: 4350-64 (2011) Article DOI: 10.1021/jm2001025 BindingDB Entry DOI: 10.7270/Q2RX9CG0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Ferrara Curated by ChEMBL | Assay Description Inhibition of human HDAC-5 using RHKK(Ac) as substrate | Eur J Med Chem 76: 53-60 (2014) Article DOI: 10.1016/j.ejmech.2014.01.056 BindingDB Entry DOI: 10.7270/Q2V40WQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Siena Curated by ChEMBL | Assay Description Inhibition of human HDAC-5 using RHKK(Ac) as substrate by fluorescence assay | J Med Chem 57: 2258-74 (2014) Article DOI: 10.1021/jm401536b BindingDB Entry DOI: 10.7270/Q2JQ12HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano Curated by ChEMBL | Assay Description Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrate | Eur J Med Chem 79: 251-9 (2014) Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano Curated by ChEMBL | Assay Description Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrate | Eur J Med Chem 79: 251-9 (2014) Article DOI: 10.1016/j.ejmech.2014.04.021 BindingDB Entry DOI: 10.7270/Q2V989KV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19410![]() (CHEMBL27759 | MS-275 | US9265734, MS-275 | benzami...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HDAC5 | Bioorg Med Chem Lett 18: 726-31 (2008) Article DOI: 10.1016/j.bmcl.2007.11.047 BindingDB Entry DOI: 10.7270/Q28W3D1M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of HDAC5 | Bioorg Med Chem Lett 18: 726-31 (2008) Article DOI: 10.1016/j.bmcl.2007.11.047 BindingDB Entry DOI: 10.7270/Q28W3D1M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Organic Synthesis Curated by ChEMBL | Assay Description Inhibition of human recombinant HDAC5 | Eur J Med Chem 44: 1067-85 (2009) Article DOI: 10.1016/j.ejmech.2008.06.020 BindingDB Entry DOI: 10.7270/Q2BG2NTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
R&D Sigma-Tau SpA Curated by ChEMBL | Assay Description Inhibition of human HDAC5 | Bioorg Med Chem Lett 19: 2346-9 (2009) Article DOI: 10.1016/j.bmcl.2009.02.029 BindingDB Entry DOI: 10.7270/Q2154GX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM/Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of wild type His-tagged HDAC5 catalytic domain T678-L1122 expressed in Escherichia coli | J Med Chem 52: 3453-6 (2009) Article DOI: 10.1021/jm9004303 BindingDB Entry DOI: 10.7270/Q2Q24044 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19410![]() (CHEMBL27759 | MS-275 | US9265734, MS-275 | benzami...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM/Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of wild type His-tagged HDAC5 catalytic domain T678-L1122 expressed in Escherichia coli | J Med Chem 52: 3453-6 (2009) Article DOI: 10.1021/jm9004303 BindingDB Entry DOI: 10.7270/Q2Q24044 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM24624![]() (CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of HDAC5 | Bioorg Med Chem Lett 19: 644-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.048 BindingDB Entry DOI: 10.7270/Q2PN95J1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19428![]() ((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM24624![]() (CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Inhibition of HDAC5 by in vitro deacetylation assay | Nat Chem Biol 6: 25-33 (2009) Article DOI: 10.1038/nchembio.275 BindingDB Entry DOI: 10.7270/Q2FF3SKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Inhibition of HDAC5 by in vitro deacetylation assay | Nat Chem Biol 6: 25-33 (2009) Article DOI: 10.1038/nchembio.275 BindingDB Entry DOI: 10.7270/Q2FF3SKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19410![]() (CHEMBL27759 | MS-275 | US9265734, MS-275 | benzami...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Curated by ChEMBL | Assay Description Inhibition of HDAC5 by in vitro deacetylation assay | Nat Chem Biol 6: 25-33 (2009) Article DOI: 10.1038/nchembio.275 BindingDB Entry DOI: 10.7270/Q2FF3SKD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human HDAC5 by fluorimetric assay | J Med Chem 53: 8387-8399 (2010) Article DOI: 10.1021/jm101092u BindingDB Entry DOI: 10.7270/Q28G8KZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 378 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human HDAC5 by fluorimetric assay | J Med Chem 53: 8387-8399 (2010) Article DOI: 10.1021/jm101092u BindingDB Entry DOI: 10.7270/Q28G8KZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19428![]() ((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human HDAC5 by fluorimetric assay | J Med Chem 53: 8387-8399 (2010) Article DOI: 10.1021/jm101092u BindingDB Entry DOI: 10.7270/Q28G8KZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita` degli Studi di Siena Curated by ChEMBL | Assay Description Inhibition of human HDAC5 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | J Med Chem 54: 2165-82 (2011) Article DOI: 10.1021/jm101373a BindingDB Entry DOI: 10.7270/Q2CR5TNZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chroma Therapeutics Ltd. Curated by ChEMBL | Assay Description Inhibition of human recombinant HDAC5 using fluor de Lys as substrate by fluorometric analysis | J Med Chem 53: 8663-78 (2010) Article DOI: 10.1021/jm101177s BindingDB Entry DOI: 10.7270/Q2G1616P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM96613![]() (2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]-N-phen...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of Harvard and MIT Curated by ChEMBL | Assay Description Inhibition of recombinant HDAC5 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay | Bioorg Med Chem Lett 21: 4164-9 (2011) Article DOI: 10.1016/j.bmcl.2011.05.098 BindingDB Entry DOI: 10.7270/Q20P10CT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (Human)) | BDBM55151![]() (1-(3,4-Dihydroxy-phenyl)-2-(4-hydroxy-6-methyl-pyr...) | KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Broad Institute of Harvard and MIT Curated by ChEMBL | Assay Description Inhibition of recombinant HDAC5 assessed as inhibition of fluorogenic aminocoumarin release from substrate by trypsin-coupled biochemical assay | Bioorg Med Chem Lett 21: 4164-9 (2011) Article DOI: 10.1016/j.bmcl.2011.05.098 BindingDB Entry DOI: 10.7270/Q20P10CT | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 71 total ) | Next | Last >> |
Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kcal/mole | -TΔS° kcal/mole | ΔH° kcal/mole | log K | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|
Methyl-accepting chemotaxis protein (McpS) (Pseudomonas putida (Arthrobacter siderocapsulatus)) | BDBM26109![]() (Butyrate | butanoic acid | butanoic acid, 4) | GoogleScholar | CHEBI DrugBank KEGG MMDB PC cid PC sid PDB | -5.41 | 2.80 | -7.88 | 4.04 | n/a | 20 | |
CSIC | J Biol Chem 285: 23126-36 (2010) | |||||||||
BDBM11![]() | BDBM36184![]() | CHEBI KEGG MMDB PC cid PC sid | CHEBI DrugBank PC cid PC sid | -3.60 | -0.783 | -2.81 | 2.64 | 6.90 | 25 | |
NIST | J Phys Chem B 101: 87-100 (1997) | |||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | GoogleScholar PDB | CHEBI DrugBank MMDB PC cid PC sid PDB | -8.36 | 2.42 | -10.9 | 6.13 | n/a | 25 | |
North Dakota State University | Biochemistry 52: 8139-49 (2013) | |||||||||
Histone deacetylase 1/3/5/8 (Homo sapiens (human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | GoogleScholar PDB | CHEBI MMDB PC cid PC sid PDB | -8.60 | 0.214 | -8.84 | 6.31 | n/a | 25 | |
North Dakota State University | Biochemistry 52: 8139-49 (2013) | |||||||||
Histone deacetylase 8 (HDAC8) (Homo sapiens (human)) | BDBM19149![]() (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | GoogleScholar PDB | CHEBI DrugBank MMDB PC cid PC sid PDB | -8.36 | 0.0519 | -8.96 | 6.34 | 7.5 | -248 | |
North Dakota State University | Biochemistry 53: 7445-58 (2014) | |||||||||
Histone deacetylase 8 (HDAC8) (Homo sapiens (human)) | BDBM50005711![]() (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | GoogleScholar PDB | DrugBank PC cid PC sid PDB | -8.60 | 0.0179 | -8.80 | 6.53 | 7.5 | -248 | |
North Dakota State University | Biochemistry 53: 7445-58 (2014) |