Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 89 hits in this display
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
Ki: 2.51E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
IC50: 5nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in sf9 cells using GS-1 as substrate after 30 mins in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
BDBM7400(6-bromo-3-[(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylide...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM50304113(CHEMBL604270 | N-((Z)-5-Bromo-3,2'-dioxo-1,3,1',2'...)
IC50: 110nMAssay Description:Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation countingMore data for this Ligand-Target Pair
BDBM50304119((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
IC50: 550nMAssay Description:Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation countingMore data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
IC50: 1.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
IC50: 1.00E+3nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
IC50: 2.20E+3nMAssay Description:Inhibition of recombinant human CDK expressed in baculovirus infected sf9 cells after 10 mins by SDS-PAGE based autoradiographyMore data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50423714((2''Z)-6-Aminoindirubin | CHEMBL609580)
IC50: 4.00E+3nMAssay Description:Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation countingMore data for this Ligand-Target Pair
BDBM7396((2 Z)-6,6 -Dibromoindirubin | 6,6 -dibromoindirubi...)
IC50: 4.50E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50304113(CHEMBL604270 | N-((Z)-5-Bromo-3,2'-dioxo-1,3,1',2'...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50304119((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
IC50: >1.00E+4nMAssay Description:Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...More data for this Ligand-Target Pair
IC50: >1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation countin...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
IC50: 2.20E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7400(6-bromo-3-[(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylide...)
IC50: 5.30E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7400(6-bromo-3-[(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylide...)
IC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
IC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7396((2 Z)-6,6 -Dibromoindirubin | 6,6 -dibromoindirubi...)
IC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7396((2 Z)-6,6 -Dibromoindirubin | 6,6 -dibromoindirubi...)
IC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7398((2 Z)-6 -Bromoindirubin | 6 -bromoindirubin | 6-br...)
IC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 2.76E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 1.22E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 1.61E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM50218890(7-bromoindirubin | CHEMBL397718 | cid_11845789)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM54680((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
BDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
EC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
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