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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
27
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Target
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human))
Academia Sinica
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
Ki: 262nM ΔG°: -37.6kJ/mole
pH: 8.0 T: 2°C
Assay Description:
The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...
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Target
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human))
Academia Sinica
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
Ki: 607nM ΔG°: -35.5kJ/mole
pH: 8.0 T: 2°C
Assay Description:
The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...
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Target
Glutaminyl-peptide cyclotransferase
(Mus musculus (mouse))
Probiodrug
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
Ki: 6.40E+3nM ΔG°: -30.1kJ/mole
pH: 8.0 T: 2°C
Assay Description:
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...
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Target
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human))
Academia Sinica
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
Ki: 7.00E+3nM ΔG°: -29.9kJ/mole
pH: 8.0 T: 2°C
Assay Description:
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...
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Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50335350
(1-(biphenyl-4-ylmethyl)-1H-imidazole | 1-Biphenyl-...)
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Affinity Data
IC50: 32nM
Assay Description:
Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 135nM
Assay Description:
Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Aromatase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of aromatase using 7-methoxy-4-trifluoromethyl coumarin as substrate after 30 mins by fluorescence-based colorimetric analysis
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Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50188087
(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
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Affinity Data
IC50: 258nM
Assay Description:
Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50188087
(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
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Affinity Data
IC50: 320nM
Assay Description:
Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Copy SMILES
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Affinity Data
IC50: 456nM
Assay Description:
Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50335350
(1-(biphenyl-4-ylmethyl)-1H-imidazole | 1-Biphenyl-...)
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Affinity Data
IC50: 637nM
Assay Description:
Inhibition of human CYP11B2 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrate
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Target
Cytochrome P450 11B1, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 709nM
Assay Description:
Inhibition of human CYP11B1 expressed in chinese hamster V79 cells
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Target
Cytochrome P450 11B2, mitochondrial
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of human CYP11B2 expressed in chinese hamster V79 cells
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: >3.00E+3nM
Assay Description:
Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alpha
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: >3.00E+3nM
Assay Description:
Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alpha
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Target
Cytochrome P450 4Z1
(Homo sapiens)
Freie Universit£T Berlin
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 5.90E+3nM
Assay Description:
Inhibition of human CYP4Z1 overexpressed in human MCF7 cells using luciferin-BE as substrate incubated for 24 hrs followed by substrate addition by l...
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Target
Cytochrome P450 4Z1
(Homo sapiens)
Freie Universit£T Berlin
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 6.70E+3nM
Assay Description:
Inhibition of human CYP4Z1 overexpressed in human MCF7 cells using luciferin-3FBE as substrate incubated for 24 hrs followed by substrate addition by...
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM50188087
(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
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Affinity Data
IC50: 8.81E+3nM
Assay Description:
Inhibition of rat microsomal 17,20-lyase component of P450-17alpha
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Target
Camphor 5-monooxygenase
(Pseudomonas putida)
University Of California
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of wild type cytochrome P450cam expressed in Escherichia coli
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Target
Aromatase
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM50188087
(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
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Affinity Data
IC50: 2.45E+4nM
Assay Description:
Inhibition of aromatase
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 3.91E+4nM
Assay Description:
Inhibition of rat microsomal 17,20-lyase component of P450-17alpha
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM50188087
(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
Copy SMILES
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Affinity Data
IC50: 5.06E+4nM
Assay Description:
Inhibition of rat microsomal 17alpha-hydroxylase component of P450-17alpha
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
Copy SMILES
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Affinity Data
IC50: 5.09E+4nM
Assay Description:
Inhibition of rat testis 17,20 lyase component of P450-17alpha
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 7.75E+4nM
pH: 7.4
Assay Description:
All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 7.75E+4nM
pH: 7.4 T: 2°C
Assay Description:
Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 1.54E+5nM
Assay Description:
Inhibition of rat testis 17alpha-hydroxylase component of P450-17alpha
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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
(Rattus norvegicus (Rat))
University Of The West Of Scotland
Curated by
ChEMBL
Ligand
BDBM7887
(1-Benzylimidazole (BI) | 1-benzyl-1H-imidazole | 1...)
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Affinity Data
IC50: 2.15E+5nM
Assay Description:
Inhibition of rat microsomal 17alpha-hydroxylase component of P450-17alpha
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