Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 44 hits in this display
BDBM50193487((3R)-3-[(2-{[2-({[(3-{[3-(dimethylamino)propyl]ami...)
BDBM50193478(CID44415032 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
BDBM50193488(CID44415033 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
BDBM50029032(CHEMBL3144208 | Methyldisulfanyl analogue of coenz...)
BDBM21735(2-methyloctanoyl CoA, 21 | {[(2R,3S,4R,5R)-5-(6-am...)
BDBM21736(2-methylmyristoyl CoA, 22)
Ki: 1.37E+5nM ΔG°: -22.9kJ/molepH: 7.0 T: 2°CAssay Description:AMACR activity was determined by monitoring the interconversion of the (25R/S)-isomer of THC-CoA. Reaction product was analyzed by resolution of (25S...More data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50270015((S-(2-oxo)pentadecyl-CoA) | CHEMBL448516)
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
IC50: 500nMAssay Description:Inhibition of recombinant p300 (unknown origin) using mixed histones and acetyl-coA as substrates incubated for 10 minsMore data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
IC50: 500nMAssay Description:Inhibition of recombinant human p300 using [14C]acetyl-CoA as substrate measured after 10 mins by phosphor imaging analysisMore data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM50260111(CHEBI:15531 | MALONYL-COENZYME A)
BDBM68278(Decyl-CoA disulfide 5)
IC50: 1.70E+4nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) using myelin basic protein as substrate incubated for 30 mins in presence or absence of DTT by [g...More data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM68277(Octyl-CoA disulfide 4)
IC50: 3.01E+4nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68275(Methyl-CoA disulfide 1)
IC50: 5.71E+4nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM50062275(CHEMBL292013 | {[5-(6-Amino-purin-9-yl)-3-hydroxy-...)
IC50: 7.30E+4nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
IC50: 1.60E+5nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) using myelin basic protein as substrate incubated for 30 mins in presence or absence of DTT by [g...More data for this Ligand-Target Pair
BDBM50255529(Ac-Lys(CoA)-NH2 | CHEMBL505121)
BDBM68277(Octyl-CoA disulfide 4)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68276(Sec-butyl-CoA disulfide 3)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68274(Butyl-CoA disulfide 2)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68275(Methyl-CoA disulfide 1)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68278(Decyl-CoA disulfide 5)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68274(Butyl-CoA disulfide 2)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM68276(Sec-butyl-CoA disulfide 3)
IC50: >3.00E+5nMpH: 7.0 T: 2°CAssay Description:Escherichia coli FabH assays were carried out using standard coupled trichloroacetic acid precipitation assay to determine the rate formation of radi...More data for this Ligand-Target Pair
BDBM50062275(CHEMBL292013 | {[5-(6-Amino-purin-9-yl)-3-hydroxy-...)
EC50: >1.00E+5nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
Kd: 156nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysisMore data for this Ligand-Target Pair
BDBM50541870(CHEBI:15351 | CHEMBL1230809)
Kd: 18nMAssay Description:Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysisMore data for this Ligand-Target Pair
Kd: 3.90E+3nMpH: 7.5 T: 2°CAssay Description:Isothermal titration calorimetry (ITC) measurements were performed at 25
°C using an iTC200 calorimeter (MicroCal). Preparations of
purified pr...More data for this Ligand-Target Pair