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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
305
hits in this display
Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 2.10nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060036
(3-[(R)-3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 2.5nM
Assay Description:
Inhibitory activity against thrombin.
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060014
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 3.30nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060052
(3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 3.30nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 4nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Homo sapiens (Human))
Nv Organon
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 6.20nM
Assay Description:
The compound was evaluated in vitro for the thrombin inhibition.
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 6.20nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472473
(CHEMBL358970)
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Affinity Data
Ki: 6.20nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 6.20nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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PC sid
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Article
PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060045
(4-[(S)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 8.70nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060056
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 8.80nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 12nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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PC sid
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 16nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472502
(CHEMBL358081)
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Affinity Data
Ki: 16nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50072846
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-1-su...)
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Affinity Data
Ki: 16nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50272181
(CHEMBL143594)
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Affinity Data
Ki: 19nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060055
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
Copy SMILES
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Affinity Data
Ki: 19nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
PDB
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060055
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
Copy SMILES
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Affinity Data
Ki: 20nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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PC sid
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Article
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50272181
(CHEMBL143594)
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Affinity Data
Ki: 20nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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DrugBank
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PC sid
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472474
(CHEMBL145630)
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Affinity Data
Ki: 21nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
Target Info
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PC sid
In Depth
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Article
PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060025
(3-{2-(Naphthalene-2-sulfonylamino)-3-oxo-3-[4-(tol...)
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Affinity Data
Ki: 22nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060038
(3-[(S)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
Copy SMILES
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Affinity Data
Ki: 23nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
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In Depth
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Article
PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060051
(3-[3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
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Affinity Data
Ki: 23nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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Ligand Info
CHEMBL
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PC sid
PDB
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In Depth
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Article
PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
Copy SMILES
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Affinity Data
Ki: 23nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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PC sid
Similars
In Depth
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PubMed
Copy BDB DOI
Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060057
(3-{2-(Naphthalene-2-sulfonylamino)-3-[4-(naphthale...)
Copy SMILES
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Affinity Data
Ki: 24nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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PC sid
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In Depth
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472450
(CHEMBL356348)
Copy SMILES
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Affinity Data
Ki: 26nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
Target Info
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In Depth
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060048
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
Copy SMILES
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Affinity Data
Ki: 26nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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PC sid
Similars
In Depth
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Article
PubMed
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
Copy SMILES
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Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50069107
(CHEMBL356792)
Copy SMILES
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Affinity Data
Ki: 27nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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Ligand Info
CHEMBL
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
Copy SMILES
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Affinity Data
Ki: 27nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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PC sid
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472491
(CHEMBL145206)
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Affinity Data
Ki: 30nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060060
(3-[3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
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Affinity Data
Ki: 36nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060050
(3-[(S)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
Copy SMILES
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Affinity Data
Ki: 36nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
Target Info
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472483
(CHEMBL145108)
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Affinity Data
Ki: 37nM
Assay Description:
Binding affinity towards thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 37nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060032
(3-[3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
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Affinity Data
Ki: 37nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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PubMed
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060040
(3-[3-(4-Benzenesulfonyl-piperazin-1-yl)-2-(naphtha...)
Copy SMILES
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Affinity Data
Ki: 41nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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PC sid
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
Copy SMILES
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Affinity Data
Ki: 44nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060037
(3-[3-(4-Ethanesulfonyl-piperazin-1-yl)-2-(naphthal...)
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Affinity Data
Ki: 44nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060026
(3-[3-(4-Butyryl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 49nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472497
(CHEMBL145211)
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Affinity Data
Ki: 52nM
Assay Description:
Binding affinity towards thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)
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Affinity Data
Ki: 58nM
Assay Description:
Inhibitory activity against thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472518
(CHEMBL344283)
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Affinity Data
Ki: 58nM
Assay Description:
Binding affinity towards thrombin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060041
(3-[3-(4-Hexanoyl-piperazin-1-yl)-2-(naphthalene-2-...)
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Affinity Data
Ki: 64nM
Assay Description:
Inhibitory activity against trypsin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472454
(CHEMBL145504)
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Affinity Data
Ki: 65nM
Assay Description:
Binding affinity towards thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 65nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
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CHEMBL
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Copy BDB DOI
Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
Copy SMILES
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Affinity Data
Ki: 65nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 67nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060021
(3-[3-(4-Cyclohexanecarbonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 72nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 73nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 97nM
Assay Description:
Inhibitory activity against trypsin
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23901
(3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-(naph...)
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Affinity Data
Ki: 110nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23908
(3-[(2S)-2-(naphthalene-2-sulfonamido)-3-oxo-3-[4-(...)
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Affinity Data
Ki: 120nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472515
(CHEMBL444601)
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Affinity Data
Ki: 120nM
Assay Description:
Binding affinity towards thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50072858
(3-[3-(3-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 130nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060051
(3-[3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060018
(3-[3-(4-Benzoyl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060038
(3-[(S)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 141nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
Copy BDB DOI
Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472473
(CHEMBL358970)
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Affinity Data
Ki: 141nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23906
(3-[(2S)-3-[4-(3-aminopropyl)piperidin-1-yl]-2-(nap...)
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Affinity Data
Ki: 160nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target Info
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MMDB
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060045
(4-[(S)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 169nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060056
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 170nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060042
(3-[3-[4-(Naphthalene-2-carbonyl)-piperazin-1-yl]-2...)
Copy SMILES
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Affinity Data
Ki: 190nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060014
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 190nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060037
(3-[3-(4-Ethanesulfonyl-piperazin-1-yl)-2-(naphthal...)
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Affinity Data
Ki: 190nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060052
(3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 190nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23880
(3-[(2S)-3-[4-(3-carbamimidamidopropanoyl)piperazin...)
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Affinity Data
Ki: 210nM ΔG°: -38.1kJ/mole
pH: 8.0 T: 2°C
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23901
(3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-(naph...)
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Affinity Data
Ki: 210nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23908
(3-[(2S)-2-(naphthalene-2-sulfonamido)-3-oxo-3-[4-(...)
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Affinity Data
Ki: 210nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472444
(CHEMBL1161244)
Copy SMILES
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Affinity Data
Ki: 219nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472483
(CHEMBL145108)
Copy SMILES
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Affinity Data
Ki: 219nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060032
(3-[3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
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Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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Copy BDB DOI
Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060025
(3-{2-(Naphthalene-2-sulfonylamino)-3-oxo-3-[4-(tol...)
Copy SMILES
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Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
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Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060053
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
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PC sid
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060030
(3-[2-Benzenesulfonylamino-3-(4-methanesulfonyl-pip...)
Copy SMILES
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Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
PDB
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CHEMBL
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PC sid
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Article
PubMed
Copy BDB DOI
Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 220nM
Assay Description:
Tested for inhibition of trypsin
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
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Affinity Data
Ki: 220nM
Assay Description:
Inhibitory activity against trypsin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472448
(CHEMBL344104)
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Affinity Data
Ki: 230nM
Assay Description:
Binding affinity towards thrombin
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50069119
(CHEMBL3403528)
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Affinity Data
Ki: 300nM
Assay Description:
Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assay
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Target Info
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Reactome pathway
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472450
(CHEMBL356348)
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Affinity Data
Ki: 319nM
Assay Description:
Binding affinity towards trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060048
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 320nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 330nM
Assay Description:
Inhibitory activity against trypsin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060040
(3-[3-(4-Benzenesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 330nM
Assay Description:
Inhibitory activity against trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 330nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
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Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 330nM
Assay Description:
Tested for inhibition of trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472454
(CHEMBL145504)
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Affinity Data
Ki: 331nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060045
(4-[(S)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 350nM
Assay Description:
Inhibitory activity against thrombin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060057
(3-{2-(Naphthalene-2-sulfonylamino)-3-[4-(naphthale...)
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Affinity Data
Ki: 400nM
Assay Description:
Inhibitory activity against trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472497
(CHEMBL145211)
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Affinity Data
Ki: 436nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50082182
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-pyrroli...)
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Affinity Data
Ki: 440nM
Assay Description:
Tested for inhibition of trypsin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060042
(3-[3-[4-(Naphthalene-2-carbonyl)-piperazin-1-yl]-2...)
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Affinity Data
Ki: 460nM
Assay Description:
Inhibitory activity against thrombin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 470nM
Assay Description:
Inhibitory activity against trypsin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060052
(3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 490nM
Assay Description:
Inhibitory activity against thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
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Affinity Data
Ki: 500nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472444
(CHEMBL1161244)
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Affinity Data
Ki: 500nM
Assay Description:
Binding affinity towards thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 500nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060053
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 510nM
Assay Description:
Inhibitory activity against thrombin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
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Affinity Data
Ki: 520nM
Assay Description:
Inhibitory activity against bovine thrombin expressed as dissociation constant
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
Copy SMILES
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Affinity Data
Ki: 520nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50069107
(CHEMBL356792)
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Affinity Data
Ki: 520nM
Assay Description:
Binding affinity towards thrombin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50072858
(3-[3-(3-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 530nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472474
(CHEMBL145630)
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Affinity Data
Ki: 549nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23906
(3-[(2S)-3-[4-(3-aminopropyl)piperidin-1-yl]-2-(nap...)
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Affinity Data
Ki: 600nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 600nM
Assay Description:
Inhibitory activity against trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472448
(CHEMBL344104)
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Affinity Data
Ki: 609nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472491
(CHEMBL145206)
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Affinity Data
Ki: 609nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50082180
(3-[3-Azocan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 610nM
Assay Description:
Tested for inhibition of trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472502
(CHEMBL358081)
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Affinity Data
Ki: 630nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50072846
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-1-su...)
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Affinity Data
Ki: 630nM
Assay Description:
Inhibitory activity against bovine trypsin expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23906
(3-[(2S)-3-[4-(3-aminopropyl)piperidin-1-yl]-2-(nap...)
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Affinity Data
Ki: 730nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50082178
(3-[3-Azepan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 740nM
Assay Description:
Tested for inhibition of trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472519
(CHEMBL609410)
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Affinity Data
Ki: 999nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060030
(3-[2-Benzenesulfonylamino-3-(4-methanesulfonyl-pip...)
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
Inhibitory activity against trypsin
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060026
(3-[3-(4-Butyryl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 1.04E+3nM
Assay Description:
Inhibitory activity against thrombin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472518
(CHEMBL344283)
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Affinity Data
Ki: 1.09E+3nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)
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Affinity Data
Ki: 1.10E+3nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
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Target
Serine protease hepsin
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069112
(CHEMBL3400827)
Copy SMILES
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060060
(3-[3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 1.30E+3nM
Assay Description:
Inhibitory activity against trypsin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060050
(3-[(S)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.30E+3nM
Assay Description:
Binding affinity towards trypsin
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Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23880
(3-[(2S)-3-[4-(3-carbamimidamidopropanoyl)piperazin...)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23901
(3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-(naph...)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060059
(3-[(S)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.60E+3nM
Assay Description:
Inhibitory activity against thrombin
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50069107
(CHEMBL356792)
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Affinity Data
Ki: 1.80E+3nM
Assay Description:
Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assay
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Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060038
(3-[(S)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.90E+3nM
Assay Description:
Inhibitory activity against thrombin
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23906
(3-[(2S)-3-[4-(3-aminopropyl)piperidin-1-yl]-2-(nap...)
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Affinity Data
Ki: 2.10E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23908
(3-[(2S)-2-(naphthalene-2-sulfonamido)-3-oxo-3-[4-(...)
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Affinity Data
Ki: 2.20E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target Info
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23901
(3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-(naph...)
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Affinity Data
Ki: 2.30E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472481
(CHEMBL145250)
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Affinity Data
Ki: 2.30E+3nM
Assay Description:
Binding affinity towards thrombin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
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Affinity Data
Ki: 2.60E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060041
(3-[3-(4-Hexanoyl-piperazin-1-yl)-2-(naphthalene-2-...)
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Affinity Data
Ki: 2.60E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23880
(3-[(2S)-3-[4-(3-carbamimidamidopropanoyl)piperazin...)
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Affinity Data
Ki: 2.80E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060055
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 2.80E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060042
(3-[3-[4-(Naphthalene-2-carbonyl)-piperazin-1-yl]-2...)
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Affinity Data
Ki: 3.00E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.30E+3nM
Assay Description:
Inhibitory activity against Plasmin.
More data for this Ligand-Target Pair
Target Info
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.30E+3nM
Assay Description:
Inhibitory activity against Kallikrein (PK)
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Target
Serine protease hepsin
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069119
(CHEMBL3403528)
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Affinity Data
Ki: 3.30E+3nM
Assay Description:
Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060037
(3-[3-(4-Ethanesulfonyl-piperazin-1-yl)-2-(naphthal...)
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Affinity Data
Ki: 3.50E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472515
(CHEMBL444601)
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Affinity Data
Ki: 3.99E+3nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 4.90E+3nM
Assay Description:
Inhibitory activity against Plasmin.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060048
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 5.00E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 5.20E+3nM
Assay Description:
Inhibitory activity against Plasmin.
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 5.20E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060062
(3-[(S)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 5.60E+3nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472522
(CHEMBL439810)
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Affinity Data
Ki: 5.70E+3nM
Assay Description:
Binding affinity towards thrombin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060056
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 6.10E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472456
(CHEMBL359422)
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Affinity Data
Ki: 6.19E+3nM
Assay Description:
Binding affinity towards thrombin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060032
(3-[3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 6.30E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060041
(3-[3-(4-Hexanoyl-piperazin-1-yl)-2-(naphthalene-2-...)
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Affinity Data
Ki: 6.50E+3nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082178
(3-[3-Azepan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 6.60E+3nM
Assay Description:
Tested for inhibition of plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM23880
(3-[(2S)-3-[4-(3-carbamimidamidopropanoyl)piperazin...)
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Affinity Data
Ki: 6.90E+3nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
Target Info
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MMDB
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 7.00E+3nM
Assay Description:
Tested for inhibition of plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Serine protease hepsin
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069107
(CHEMBL356792)
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Affinity Data
Ki: 7.00E+3nM
Assay Description:
Inhibition of hepsin (unknown origin) using Boc-QAR-AMC as substrate after 30 mins prior to substrate addition by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 7.00E+3nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060050
(3-[(S)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 7.10E+3nM
Assay Description:
Inhibitory activity against thrombin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060018
(3-[3-(4-Benzoyl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 7.20E+3nM
Assay Description:
Inhibitory activity against plasmin
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 7.30E+3nM
Assay Description:
Inhibitory activity against Kallikrein (PK)
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060042
(3-[3-[4-(Naphthalene-2-carbonyl)-piperazin-1-yl]-2...)
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Affinity Data
Ki: 7.30E+3nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060018
(3-[3-(4-Benzoyl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 7.60E+3nM
Assay Description:
Inhibitory activity against thrombin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082180
(3-[3-Azocan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 7.80E+3nM
Assay Description:
Tested for inhibition of plasmin
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472481
(CHEMBL145250)
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Affinity Data
Ki: 7.94E+3nM
Assay Description:
Binding affinity towards trypsin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060051
(3-[3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 8.40E+3nM
Assay Description:
Inhibitory activity against plasmin
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060045
(4-[(S)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 8.50E+3nM
Assay Description:
Inhibitory activity against trypsin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060026
(3-[3-(4-Butyryl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 8.60E+3nM
Assay Description:
Inhibitory activity against plasmin
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Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 9.00E+3nM
Assay Description:
Inhibitory activity against Plasmin.
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Target Info
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060048
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 9.70E+3nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472450
(CHEMBL356348)
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Affinity Data
Ki: 9.70E+3nM
Assay Description:
Binding affinity towards Coagulation factor Xa
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Target Info
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 9.70E+3nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Target Info
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Target
Hepatocyte growth factor activator
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069119
(CHEMBL3403528)
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Affinity Data
Ki: 1.01E+4nM
Assay Description:
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
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Affinity Data
Ki: 1.02E+4nM
Assay Description:
Tested for inhibition of plasmin
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060021
(3-[3-(4-Cyclohexanecarbonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 1.02E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
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Affinity Data
Ki: 1.02E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.03E+4nM
Assay Description:
Inhibitory activity against Activated protein C
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Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060057
(3-{2-(Naphthalene-2-sulfonylamino)-3-[4-(naphthale...)
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Affinity Data
Ki: 1.10E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060059
(3-[(S)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.11E+4nM
Assay Description:
Inhibitory activity against trypsin
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
Inhibitory activity against Activated protein C
More data for this Ligand-Target Pair
Target Info
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23908
(3-[(2S)-2-(naphthalene-2-sulfonamido)-3-oxo-3-[4-(...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082182
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-pyrroli...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
Tested for inhibition of plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060014
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060053
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 1.20E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060052
(3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 1.30E+4nM
Assay Description:
Inhibitory activity against trypsin
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 1.35E+4nM
Assay Description:
Inhibitory activity against Activated protein C
More data for this Ligand-Target Pair
Target Info
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060053
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 1.40E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50069112
(CHEMBL3400827)
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Affinity Data
Ki: 1.49E+4nM
Assay Description:
Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assay
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060025
(3-{2-(Naphthalene-2-sulfonylamino)-3-oxo-3-[4-(tol...)
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Affinity Data
Ki: 1.50E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.50E+4nM
Assay Description:
Inhibitory activity against Kallikrein (PK)
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50472519
(CHEMBL609410)
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Affinity Data
Ki: 1.51E+4nM
Assay Description:
Binding affinity towards thrombin
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 1.52E+4nM
Assay Description:
Inhibitory activity against Activated protein C
More data for this Ligand-Target Pair
Target Info
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472456
(CHEMBL359422)
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Affinity Data
Ki: 1.59E+4nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 1.60E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060018
(3-[3-(4-Benzoyl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 1.60E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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Details
Article
PubMed
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Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472448
(CHEMBL344104)
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Affinity Data
Ki: 1.69E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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Article
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060038
(3-[(S)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.70E+4nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Hepatocyte growth factor activator
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069107
(CHEMBL356792)
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Affinity Data
Ki: 1.82E+4nM
Assay Description:
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060032
(3-[3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082180
(3-[3-Azocan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Tested for inhibition of plasminogen activator urokinase (microPa)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
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Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060041
(3-[3-(4-Hexanoyl-piperazin-1-yl)-2-(naphthalene-2-...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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Article
PubMed
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060040
(3-[3-(4-Benzenesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472483
(CHEMBL145108)
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Affinity Data
Ki: 1.90E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472444
(CHEMBL1161244)
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Affinity Data
Ki: 2.09E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
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Affinity Data
Ki: 2.10E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.10E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
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Details
Article
PubMed
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 2.10E+4nM
Assay Description:
Inhibitory activity against Plasmin.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472491
(CHEMBL145206)
Copy SMILES
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Affinity Data
Ki: 2.19E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472519
(CHEMBL609410)
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Affinity Data
Ki: 2.19E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060052
(3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 2.19E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060014
(3-[3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphtha...)
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Affinity Data
Ki: 2.20E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 2.20E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060045
(4-[(S)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 2.39E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060056
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
Copy SMILES
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23908
(3-[(2S)-2-(naphthalene-2-sulfonamido)-3-oxo-3-[4-(...)
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060040
(3-[3-(4-Benzenesulfonyl-piperazin-1-yl)-2-(naphtha...)
Copy SMILES
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060037
(3-[3-(4-Ethanesulfonyl-piperazin-1-yl)-2-(naphthal...)
Copy SMILES
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060025
(3-{2-(Naphthalene-2-sulfonylamino)-3-oxo-3-[4-(tol...)
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060057
(3-{2-(Naphthalene-2-sulfonylamino)-3-[4-(naphthale...)
Copy SMILES
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Affinity Data
Ki: 2.50E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Serine protease 1
(Bos taurus (bovine))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472522
(CHEMBL439810)
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Affinity Data
Ki: 2.51E+4nM
Assay Description:
Binding affinity towards trypsin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472474
(CHEMBL145630)
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Affinity Data
Ki: 2.60E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472522
(CHEMBL439810)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.60E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50069107
(CHEMBL356792)
Copy SMILES
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Affinity Data
Ki: 2.69E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 2.70E+4nM
Assay Description:
Inhibitory activity against Kallikrein (PK)
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
Copy SMILES
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Affinity Data
Ki: 2.70E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.70E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
Copy SMILES
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Inhibitory activity against UK.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
Copy SMILES
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Inhibitory activity against UK.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082178
(3-[3-Azepan-1-yl-2-(naphthalene-2-sulfonylamino)-3...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Tested for inhibition of plasminogen activator urokinase (microPa)
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060030
(3-[2-Benzenesulfonylamino-3-(4-methanesulfonyl-pip...)
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Affinity Data
Ki: 2.90E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060030
(3-[2-Benzenesulfonylamino-3-(4-methanesulfonyl-pip...)
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Affinity Data
Ki: 2.90E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060050
(3-[(S)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 2.99E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
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Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060060
(3-[3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 3.00E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PubMed
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.00E+4nM
Assay Description:
Inhibitory activity against Plasmin.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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Ligand Info
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PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 3.10E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50072858
(3-[3-(3-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 3.20E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.20E+4nM
Assay Description:
Inhibitory activity against UK.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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CHEMBL
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Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.40E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50072846
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-1-su...)
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Affinity Data
Ki: 3.40E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Ligand Info
CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.40E+4nM
Assay Description:
Inhibitory activity against UK.
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
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Article
PubMed
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Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472518
(CHEMBL344283)
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Affinity Data
Ki: 3.49E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)
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Affinity Data
Ki: 3.50E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50072858
(3-[3-(3-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 3.50E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
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Article
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 3.50E+4nM
Assay Description:
Inhibitory activity against plasma kallikrein (PK.)
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
UniProtKB/SwissProt
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Ligand Info
CHEMBL
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Target
Prothrombin
(Bos taurus (Bovine))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060021
(3-[3-(4-Cyclohexanecarbonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 3.60E+4nM
Assay Description:
Inhibitory activity against thrombin
More data for this Ligand-Target Pair
Target Info
PDB
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CHEMBL
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PC sid
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PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
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Affinity Data
Ki: 3.80E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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CHEMBL
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PC sid
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Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
Copy SMILES
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Affinity Data
Ki: 3.80E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
Copy SMILES
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Affinity Data
Ki: 3.80E+4nM
Assay Description:
Tested for inhibition of plasminogen activator urokinase (microPa)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060049
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperid...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.80E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472454
(CHEMBL145504)
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Affinity Data
Ki: 3.80E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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PubMed
Copy BDB DOI
Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060062
(3-[(S)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 3.90E+4nM
Assay Description:
Inhibitory activity against trypsin
More data for this Ligand-Target Pair
Target Info
PDB
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GoogleScholar
Ligand Info
CHEMBL
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PC sid
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Article
PubMed
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 3.90E+4nM
Assay Description:
Inhibitory activity against Activated protein C
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060047
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-(4-phen...)
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Affinity Data
Ki: 4.10E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472473
(CHEMBL358970)
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Affinity Data
Ki: 4.10E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 4.10E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.10E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472502
(CHEMBL358081)
Copy SMILES
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Affinity Data
Ki: 4.19E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Ligand Info
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50072846
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-1-su...)
Copy SMILES
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Affinity Data
Ki: 4.20E+4nM
Assay Description:
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060015
(3-[3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(napht...)
Copy SMILES
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Affinity Data
Ki: 4.20E+4nM
Assay Description:
Inhibitory activity against plasmin
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472515
(CHEMBL444601)
Copy SMILES
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Affinity Data
Ki: 4.67E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50060038
(3-[(S)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 4.79E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
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Affinity Data
Ki: 4.80E+4nM
Assay Description:
Tested for inhibition of plasminogen activator urokinase (microPa)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060051
(3-[3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-2-su...)
Copy SMILES
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Affinity Data
Ki: 4.80E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060043
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperaz...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.80E+4nM
Assay Description:
Inhibitory activity against human urokinase plasminogen activator expressed as dissociation constant
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Target
Hepatocyte growth factor activator
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50069112
(CHEMBL3400827)
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Affinity Data
Ki: >5.00E+4nM
Assay Description:
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...
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Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472497
(CHEMBL145211)
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Affinity Data
Ki: 5.00E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 5.20E+4nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 5.30E+4nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target
Plasminogen
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060060
(3-[3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
Ki: 5.50E+4nM
Assay Description:
Inhibitory activity against plasmin
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23880
(3-[(2S)-3-[4-(3-carbamimidamidopropanoyl)piperazin...)
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Affinity Data
Ki: 5.60E+4nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Plasma kallikrein
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 5.80E+4nM
Assay Description:
Inhibitory activity against Kallikrein (PK)
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060021
(3-[3-(4-Cyclohexanecarbonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 5.80E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472481
(CHEMBL145250)
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Affinity Data
Ki: 6.02E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: 6.10E+4nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23906
(3-[(2S)-3-[4-(3-aminopropyl)piperidin-1-yl]-2-(nap...)
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Affinity Data
Ki: 6.60E+4nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50082182
(3-[2-(Naphthalene-2-sulfonylamino)-3-oxo-3-pyrroli...)
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Affinity Data
Ki: 7.30E+4nM
Assay Description:
Compound was tested for inhibition of plasminogen activator urokinase(microPa).
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Target
Anionic trypsin
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060050
(3-[(S)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 7.30E+4nM
Assay Description:
Inhibitory activity against trypsin
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM23901
(3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-(naph...)
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Affinity Data
Ki: 7.60E+4nM
Assay Description:
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060055
(4-[3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2-sul...)
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Affinity Data
Ki: 7.70E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50272181
(CHEMBL143594)
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Affinity Data
Ki: 7.76E+4nM
Assay Description:
Binding affinity towards Coagulation factor Xa
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Target
Coagulation factor X
(Bos taurus)
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060026
(3-[3-(4-Butyryl-piperazin-1-yl)-2-(naphthalene-2-s...)
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Affinity Data
Ki: 8.00E+4nM
Assay Description:
Inhibitory activity against coagulation factor X.
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Target
Vitamin K-dependent protein C
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 9.40E+4nM
Assay Description:
Inhibitory activity against Activated protein C
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Target Info
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.10E+5nM
Assay Description:
Inhibitory activity against urokinase (UK )
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 1.10E+5nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
More data for this Ligand-Target Pair
Target Info
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 1.40E+5nM
Assay Description:
Inhibitory activity against UK.
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Target Info
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 1.80E+5nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
More data for this Ligand-Target Pair
Target Info
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: 1.90E+5nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 2.00E+5nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target Info
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 2.80E+5nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target
Coagulation factor X
(Homo sapiens (Human))
University Of Marburg
Curated by
ChEMBL
Ligand
BDBM50472456
(CHEMBL359422)
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Affinity Data
Ki: 3.59E+5nM
Assay Description:
Binding affinity towards Coagulation factor Xa
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Target Info
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Target
Coagulation factor XII
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: 4.00E+5nM
Assay Description:
Inhibitory activity against Coagulation factor XII
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Target Info
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: 4.10E+5nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
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Target Info
PDB
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060024
(3-[(R)-3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-(n...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
More data for this Ligand-Target Pair
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060017
(3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(nap...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
More data for this Ligand-Target Pair
Target Info
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060031
(3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
More data for this Ligand-Target Pair
Target Info
PDB
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Reactome pathway
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
More data for this Ligand-Target Pair
Target Info
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060023
(3-[(R)-3-(4-Formyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
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Target
Kallikrein-1
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060029
(3-[(R)-3-(4-Acetyl-piperazin-1-yl)-2-(naphthalene-...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against glandular kallikrein (GK)
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Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
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CHEMBL
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Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Klinikum Der Friedrich-Schiller-Universit£T Jena
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory activity against single-chain tissue-type plasminogen activator (sc-tissue plasminogen activator)
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Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Prothrombin
(Homo sapiens (Human))
Nv Organon
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
IC50: 640nM
Assay Description:
In vitro thrombin inhibition
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Target
Serine protease 1
(Homo sapiens (Human))
Nv Organon
Curated by
ChEMBL
Ligand
BDBM50060033
(3-[3-(4-Methyl-piperidin-1-yl)-2-(naphthalene-2-su...)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
In vitro trypsin inhibition
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Target Info
PDB
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KEGG
UniProtKB/SwissProt
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Target
Serine protease hepsin
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50272181
(CHEMBL143594)
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Affinity Data
IC50: 6.19E+3nM
Assay Description:
Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...
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Target Info
PDB
MMDB
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Article
PubMed
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Target
Serine protease hepsin
(Homo sapiens (Human))
Washington University
Curated by
ChEMBL
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
IC50: 6.55E+3nM
Assay Description:
Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
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PC sid
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Article
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Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Curacyte Chemistry
Ligand
BDBM50060035
(4-[(R)-3-(3-Carbamimidoyl-phenyl)-2-(naphthalene-2...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of uPA (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
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CHEMBL
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