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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
156
hits in this display
Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 2.66nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 3.40nM
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Target
Nicotinic acetylcholine receptor
(RAT)
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 4nM
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.20nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.80nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.60nM
Assay Description:
Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-2/beta-2
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
More data for this Ligand-Target Pair
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Target
Nicotinic acetylcholine receptor
(RAT)
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 32.8nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 33nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 39nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-2
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 41nM
Assay Description:
Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand
More data for this Ligand-Target Pair
Target Info
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NCI pathway
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 44nM
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
Nicotinic acetylcholine receptor
(RAT)
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 45nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 45nM
Assay Description:
Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Nicotinic acetylcholine receptor
(RAT)
National Institute On Drug Abuse
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 47.3nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
Georgetown University
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 56nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 58nM
More data for this Ligand-Target Pair
Target Info
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Target
Uncharacterized protein
(Chick)
University Of Milan
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 72nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-4
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 83nM
Assay Description:
Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 99nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 110nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-2
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 110nM
More data for this Ligand-Target Pair
Target Info
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Target
Cholinergic receptor nicotinic alpha 6 subunit
(Chick)
University Of Milan
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 123nM
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 158nM
Assay Description:
Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cells
Checked by Author
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PDB
3D Structure (crystal)
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 340nM
More data for this Ligand-Target Pair
Target Info
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3D Structure (crystal)
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 347nM
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 380nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M2 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 390nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liqu...
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 430nM
More data for this Ligand-Target Pair
Target Info
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 501nM
Assay Description:
Displacement of [3H]epibatidine from chimeric human alpha7-5-HT3A receptor expressed in HEK293 cells after 2 hrs by scintillation counter analysis
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
Georgetown University
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 620nM
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M2
(RAT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 700nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
Ki: 800nM
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 820nM
Assay Description:
Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
Georgetown University
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 850nM
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 881nM
Assay Description:
Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
Georgetown University
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 881nM
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Target
Cannabinoid receptor 1
(Hirudo medicinalis)
State University Of New York At Old Westbury
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 1.00E+3nM
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Target
Muscarinic acetylcholine receptor M2
(RAT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 2.00E+3nM
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Target
Muscarinic acetylcholine receptor M3
(RAT)
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 2.40E+3nM
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Institute
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 3.16E+3nM
Assay Description:
Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP
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Target
Beta-arrestin-1
(RABBIT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 3.23E+3nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 4.20E+3nM
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.70E+3nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M3 receptor expressed in HEK293T cell membranes after 1 hr by liqu...
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 5.40E+3nM
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.80E+3nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M1 receptor expressed in HEK293T cell membranes after 1 hr by liqu...
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Institute
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.31E+3nM
Assay Description:
Displacement of [3H]-epibatidine from histidine-tagged Lymnaea stagnalis AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.76E+3nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M3 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.80E+3nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M3 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
More data for this Ligand-Target Pair
Target Info
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.08E+3nM
Assay Description:
Displacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in CHO cells
Checked by Author
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
Ki: 7.94E+3nM
Assay Description:
Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells after 1.5 hrs by liquid scintillation counting
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.51E+3nM
Assay Description:
Displacement of [3H]NMS from human cloned muscarinic M4 receptor expressed in CHO cells
Checked by Author
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.77E+3nM
Assay Description:
Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in CHO cells
Checked by Author
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M2
(RAT)
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.26E+4nM
Assay Description:
Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin)
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.35E+4nM
Assay Description:
Displacement of [3H]NMS from human cloned muscarinic M1 receptor expressed in CHO cells
Checked by Author
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.29E+4nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M1 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
More data for this Ligand-Target Pair
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.30E+4nM
Assay Description:
Displacement of [3H]N-methyl-scopolamine from human recombinant muscarinic M1 receptor expressed in CHO-FlpIn cells after 6 hrs by liquid scintillati...
More data for this Ligand-Target Pair
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.70E+5nM
Assay Description:
Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scin...
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Target
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...
More data for this Ligand-Target Pair
Target Info
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
IC50: 12nM
Assay Description:
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: 12nM
Assay Description:
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.
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Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
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Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: 135nM
Assay Description:
Agonist activity at human muscarinic M1 receptor expressed in HEK293T cells co-expressing Galpha subunit and PLC-beta3 by split luciferase complement...
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Galanin receptor type 3
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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IC50: 618nM
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Galanin receptor type 3
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
IC50: 1.66E+3nM
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: 2.40E+4nM
Assay Description:
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: 2.40E+4nM
Assay Description:
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.
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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5
(RAT)
Smithkline Beecham Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: 2.40E+4nM
Assay Description:
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...
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Neuropeptide Y receptor type 1
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
IC50: >3.50E+4nM
Assay Description:
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...
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Neuropeptide Y receptor type 2
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
IC50: >3.50E+4nM
Assay Description:
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...
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Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 49nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 49nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-mediated cAMP accumulation...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 1.91E+3nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arres...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 1.90E+3nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in HEK293 cells co-expressing beta-arrestin assessed as increase in beta-arres...
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Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 47nM
Assay Description:
Agonist activity at recombinant human muscarinic M1 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 47nM
Assay Description:
Agonist activity at recombinant human muscarinic M1 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 13nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 23nM
Assay Description:
Agonist activity at recombinant human muscarinic M3 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 23nM
Assay Description:
Agonist activity at recombinant human muscarinic M3 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 13nM
Assay Description:
Agonist activity at recombinant human muscarinic M2 receptor expressed in CHO cells assessed as upregulation in ERK1/2 phosphorylation after 5 mins b...
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Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 56nM
Assay Description:
Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumul...
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Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.40E+4nM
Assay Description:
Agonist activity at rat alpha4beta2 expressed in Xenopus oocytes at -60 mV holding potential by electrophysiology method
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Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
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Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.10E+5nM
Assay Description:
Agonist activity at rat alpha7 nAChR expressed in Xenopus oocytes at -60 mV holding potential by electrophysiology method
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Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
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Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 57nM
Assay Description:
Positive allosteric modulatory activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assess...
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Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 43nM
Assay Description:
Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...
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Resistance to inhibitors of cholinesterase protein 3
(Pig roundworm)
Iowa State University Research Foundation
US Patent
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 6.36E+3nM
Assay Description:
Nematode eggs are isolated from fresh feces by centrifugation and flotation. The eggs are washed and inspected to confirm embryonation has not starte...
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G protein-activated inward rectifier potassium channel 1
(Rattus norvegicus)
Vanderbilt Screening Center For Gpcrs, Ion Channels And Transporters
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 0.0614nM
Assay Description:
Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...
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Tropomyosin alpha-1 chain
(Sus scrofa)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: >7.14E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Acetylcholine-binding protein
(Lymnaea stagnalis)
Institute
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
Kd: 458nM
pH: 7.4 T: 2°C
Assay Description:
Interaction assay using AChBP.
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Institute
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
Kd: 3.85E+3nM
pH: 7.4 T: 2°C
Assay Description:
Interaction assay using AChBP.
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.70E+5nM
Assay Description:
Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2
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Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 3.00E+4nM
Assay Description:
Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)
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Target
Acetylcholine receptor subunit delta
(Torpedo californica)
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 4.00E+4nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
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Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.00E+4nM
Assay Description:
Agonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cells.
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Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 630nM
Assay Description:
Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cells.
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.00E+5nM
Assay Description:
Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
Kd: 1.74E+4nM
Assay Description:
Displacement of [3H]NMS from human muscarinic M1 acetylcholine receptor expressed in CHO cell membranes by radioligand binding assay
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 372nM
Assay Description:
Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for ...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
Kd: 1.74E+4nM
Assay Description:
Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin)
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.28E+5nM
Assay Description:
Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assay
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.09E+5nM
Assay Description:
Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.05E+5nM
Assay Description:
Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 400nM
Assay Description:
Agonist activity at human alpha4beta2 nAChR high affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holdin...
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.00E+5nM
Assay Description:
Agonist activity at human alpha4beta2 nAChR in (alpha4)3(beta2)2 stoichiometry form
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 1.00E+5nM
Assay Description:
Agonist activity at human alpha4beta2 nAChR low affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding...
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.00E+3nM
Assay Description:
Agonist activity at human alpha4beta2 nAChR in (alpha4)2(beta2)3 stoichiometry form
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 26nM
Assay Description:
Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 7nM
Assay Description:
Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 205nM
Assay Description:
Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 49nM
Assay Description:
Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 19nM
Assay Description:
Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay
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Target
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human))
Copenhagen University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.90E+4nM
Assay Description:
Agonist activity at alpha3beta4 nAChR (unknown origin) expressed in HEK293 cells by FLIPR membrane potential assay
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 8.70E+4nM
Assay Description:
Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 6.90E+4nM
Assay Description:
Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylat...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 770nM
Assay Description:
Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 220nM
Assay Description:
Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 790nM
Assay Description:
Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.30E+5nM
Assay Description:
Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM.
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.55E+5nM
Assay Description:
Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7
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Neuronal acetylcholine receptor subunit alpha-3/beta-2
(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 4.43E+5nM
Assay Description:
Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes
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Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.80E+5nM
Assay Description:
Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes
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Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 4.00E+3nM
Assay Description:
Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assay
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 4.00E+3nM
Assay Description:
Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assay
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Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.60E+3nM
Assay Description:
Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp technique
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Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences
Curated by
PDSP K
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Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 3.12E+3nM
Assay Description:
Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for...
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Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat))
Georgetown University
Curated by
PDSP K
i
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Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 8.90E+3nM
Assay Description:
Agonist activity at rat alpha-3-beta-4 nAChR expressed in HEK293 cells by FMP assay
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Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human))
Copenhagen University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.44E+5nM
Assay Description:
Agonist activity at human alpha-3-beta-4 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique
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Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human))
Abbott Laboratories
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 7.00E+4nM
Assay Description:
Agonist activity at human alpha-4-beta-2 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Bezmialem Vakif University
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 8.30E+4nM
Assay Description:
Agonist activity at human alpha-7 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique
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Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.00E+3nM
Assay Description:
Agonist activity at alpha4beta2 nAChR high sensitivity form
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.00E+5nM
Assay Description:
Agonist activity at alpha4beta2 nAChR low sensitivity form
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 220nM
Assay Description:
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
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Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.10nM
Assay Description:
Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
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Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.20nM
Assay Description:
Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
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Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 3.20nM
Assay Description:
Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
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Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 10nM
Assay Description:
Agonist activity at muscarinic human M4 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.10nM
Assay Description:
Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
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Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 220nM
Assay Description:
Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 3.20nM
Assay Description:
Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
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Target
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 10nM
Assay Description:
Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...
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Target
Muscarinic acetylcholine receptor M5
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.20nM
Assay Description:
Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 2.17E+5nM
Assay Description:
Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in Xenopus oocytes using [3H]-epibatidine as radioligand
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat))
Swiss Federal Institute Of Technology Zurich
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 8.70E+4nM
Assay Description:
Inhibition of [3H]-nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-4
(Rattus norvegicus (Rat))
Georgetown University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 1.90E+4nM
Assay Description:
Inhibition of [3H]-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
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Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 617nM
Assay Description:
Agonist activity at Gq/11 coupled recombinant human muscarinic M1 AChR expressed in CHO-FlpIn cells assessed as IP-one accumulation after 40 mins by ...
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Target
Muscarinic acetylcholine receptor M1
(Homo sapiens (Human))
University Of Arizona
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 620nM
Assay Description:
Agonist activity at Gq/11 coupled recombinant human muscarinic M1 AChR expressed in CHO-FlpIn cells assessed as IP-one accumulation after 40 mins by ...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 240nM
Assay Description:
Agonist activity at Gq/11 coupled recombinant human muscarinic M3 AChR expressed in CHO-FlpIn cells assessed as IP-one accumulation after 40 mins by ...
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Target
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human))
University Of Arkansas
Curated by
PDSP K
i
Database
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
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Affinity Data
EC50: 240nM
Assay Description:
Agonist activity at Gq/11 coupled recombinant human muscarinic M3 AChR expressed in CHO-FlpIn cells assessed as IP-one accumulation after 40 mins by ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
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Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
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Affinity Data
EC50: 513nM
Assay Description:
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM10759
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 510nM
Assay Description:
Agonist activity at Gi/o protein-coupled recombinant human muscarinic M2 receptor expressed in CHO-FlpIn cells preincubated for 60 mins followed by [...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
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