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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18152((2S,3S)-2-amino-3,4-dimethylpentanoic acid | L-2-A...)
Affinity DataKi:  4.55E+4nM ΔG°:  -24.4kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18144(2-amino-3-ethylpentanoic acid | DL-2-Amino-3-ethyl...)
Affinity DataKi:  5.30E+5nM ΔG°:  -18.4kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18145((2S)-2-amino-3-ethylpentanoic acid | L-2-Amino-3-e...)
Affinity DataKi:  5.60E+5nM ΔG°:  -18.2kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18146(2-amino-3,3-dimethylpentanoic acid | DL-2-Amino-3,...)
Affinity DataKi:  1.25E+6nM ΔG°:  -16.3kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18153((3R)-2-amino-3,4-dimethylpentanoic acid | DL-2-Ami...)
Affinity DataKi:  3.33E+6nM ΔG°:  -13.9kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18154((2S,3R)-2-amino-3,4-dimethylpentanoic acid | L-2-A...)
Affinity DataKi:  5.00E+6nM ΔG°:  -12.9kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProton-coupled amino acid transporter 1(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataKi:  3.70E+7nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataIC50:  1.40E+5nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLarge neutral amino acids transporter small subunit 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50463207(CHEMBL4239366)
Affinity DataIC50: >3.00E+6nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed