Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 10 hits in this display
BDBM18152((2S,3S)-2-amino-3,4-dimethylpentanoic acid | L-2-A...)
BDBM18144(2-amino-3-ethylpentanoic acid | DL-2-Amino-3-ethyl...)
Ki: 5.30E+5nM ΔG°: -18.4kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
BDBM18145((2S)-2-amino-3-ethylpentanoic acid | L-2-Amino-3-e...)
Ki: 5.60E+5nM ΔG°: -18.2kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
BDBM18146(2-amino-3,3-dimethylpentanoic acid | DL-2-Amino-3,...)
Ki: 1.25E+6nM ΔG°: -16.3kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
BDBM18153((3R)-2-amino-3,4-dimethylpentanoic acid | DL-2-Ami...)
Ki: 3.33E+6nM ΔG°: -13.9kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
BDBM18154((2S,3R)-2-amino-3,4-dimethylpentanoic acid | L-2-A...)
Ki: 5.00E+6nM ΔG°: -12.9kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
BDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
Ki: 3.70E+7nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
BDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
BDBM18140((2S,3S)-2-amino-3-methylpentanoic acid | Isoleucin...)
IC50: >3.00E+6nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair