Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 75 hits in this display   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  1.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  1.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRas-related protein Rab-7a(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  2.70E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Oxagen

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity towards human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi:  4.24E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  4.85E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  5.11E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi:  7.52E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
Molecular Discovery

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataKi:  2.63E+4nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataKi:  7.79E+4nMAssay Description:Inhibition of glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataKi:  1.39E+5nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ovine COX1 after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant COX2 after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  115nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50272862((E)-2'-des-methyl sulindac sulfide | 2-desmethylsu...)
Affinity DataIC50:  116nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells using [14C] arachidonic acid as substrate preincubated for 30 mins before substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  140nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50293599((Z)-2'-des-methyl sulindac sulfide | CHEMBL561959)
Affinity DataIC50:  147nMAssay Description:Competitive inhibition of mouse COX2 under reduced substrate concentration by TLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute Of Information Technology

LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50:  293nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  374nMAssay Description:Inhibition of Homo sapiens (human) aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50293599((Z)-2'-des-methyl sulindac sulfide | CHEMBL561959)
Affinity DataIC50:  375nMAssay Description:Competitive inhibition of ovine COX1 under reduced substrate concentration by TLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50272862((E)-2'-des-methyl sulindac sulfide | 2-desmethylsu...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50272862((E)-2'-des-methyl sulindac sulfide | 2-desmethylsu...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of ovine COX-1 using [14C] arachidonic acid as substrate preincubated for 17 mins before substrate addition measured after 3 mins by thin-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by microplate reader...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50:  2.69E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50272862((E)-2'-des-methyl sulindac sulfide | 2-desmethylsu...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Zafes/Liff/Goethe University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  5.30E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  5.71E+4nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  6.37E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of microsomal PGESMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  8.25E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50:  8.29E+4nMAssay Description:Displacement of [3H]-9-cis-RA from RXRalpha (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  8.75E+4nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-lipoxygenase in intact RBL-1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  2.15E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataIC50:  2.26E+5nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataIC50:  3.32E+5nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  4.86E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-7a(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRas-related protein Rab-7a(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  4.12E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  4.67E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  5.33E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM54707(2-[(3E)-6-fluoranyl-2-methyl-3-[(4-methylsulfinylp...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  5.47E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataEC50:  380nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50273066((E)-2-(5-Fluoro-1-((4-(methylthio)biphenyl-4-yl)me...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50272901((E)-2-(5-Fluoro-1-(4-(methylsulfonyl)benzylidene)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50272861((E)-2-(5-Fluoro-1-(4-(methylsulfinyl)benzylidene)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50272862((E)-2'-des-methyl sulindac sulfide | 2-desmethylsu...)
Affinity DataEC50:  700nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C5(Homo sapiens)
Indian Institute Of Technology Bhubaneswar

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataKd:  570nMAssay Description:Binding affinity to human C5a assessed as dissociation constant after 1 hr by circular dichroism analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataEC50:  2.27E+4nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50110164((Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-me...)
Affinity DataEC50:  800nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50103504(CHEBI:9352 | Clinoril | Sulindac)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to GAL4-DBD-fused PPARgamma ligand binding domain (unknown origin) expressed in HEK293T cells by spectra-fluorophotometry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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