Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 24 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29755(hydroxyethylamine derivative, 4)
Affinity DataIC50:  9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  40nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  49nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50:  63nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  180nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 40 production by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 assessed as beta amyloid 42 production by cell based assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM50231699(CHEMBL252860 | N-((2S,3R)-4-(benzylamino)-3-hydrox...)
Affinity DataIC50:  760nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50:  930nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gsk

LigandPNGBDBM50231675(CHEMBL402122 | N-((2S,3R)-4-(cyclopentylamino)-3-h...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50:  3.39E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50:  4.27E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  4.49E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  6.58E+3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29757(hydroxyethylamine derivative, 7)
Affinity DataIC50:  9.12E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231675(CHEMBL402122 | N-((2S,3R)-4-(cyclopentylamino)-3-h...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231699(CHEMBL252860 | N-((2S,3R)-4-(benzylamino)-3-hydrox...)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231675(CHEMBL402122 | N-((2S,3R)-4-(cyclopentylamino)-3-h...)
Affinity DataIC50:  4.17E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231699(CHEMBL252860 | N-((2S,3R)-4-(benzylamino)-3-hydrox...)
Affinity DataIC50:  6.31E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed