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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 286 hits in this display   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  0.230nM Kd:  1.13nM Koff:  4.43E+6s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKi:  0.910nMAssay Description:Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKi:  67.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLong-chain-fatty-acid--AMP ligase FadD32(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50565056(CHEMBL4783416)
Affinity DataKi:  110nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv FAAL32 expressed in Escherichia coli BL21(DE3) cells incubated for 2 hrs in presence of [C14] fatty ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataKi:  131nMAssay Description:Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81592(AppppA analog, 17 (X=O))
Affinity DataKi:  420nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKi:  452nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81587(AppppA analog, 14 (X=O))
Affinity DataKi:  900nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin(RAT)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholecystokinin(RAT)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81583(AppppA analog, 12 (X=O))
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81589(AppppA analog, 15 (X=O))
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Rattus norvegicus (Rat))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50056973(CHEMBL519155 | NSC-255523)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50056973(CHEMBL519155 | NSC-255523)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50552885(CHEBI:16771 | CHEMBL583986)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81585(AppppA analog, 13 (X=O))
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBis(5'-adenosyl)-triphosphatase(Homo sapiens (Human))
Kimmel Cancer Center

LigandPNGBDBM81577(AppppA analog, 6 (X=O))
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition assay using Fhit with ApppBODIPY.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransmembrane and immunoglobulin domain-containing 3(RAT)
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndoplasmin(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50552885(CHEBI:16771 | CHEMBL583986)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86481(AP2A | CAS_0 | NSC_0)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86481(AP2A | CAS_0 | NSC_0)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Rattus norvegicus (Rat))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50056972(CHEMBL3331361)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50056972(CHEMBL3331361)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  1.92E+4nMAssay Description:Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Rattus norvegicus (Rat))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Rattus norvegicus (Rat))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM92538(AMP | [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2...)
Affinity DataKi:  4.00E+4nMAssay Description:Rcl inhibition by nucleotides.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine--tRNA ligase(Bombyx mori)
Medical College Of Ohio

LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  8.00E+4nM ΔG°:  -23.4kJ/mole IC50:  8.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibitory activity against rat adenylate kinase II was determined in the presence of AMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Homo sapiens (Human))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKi:  1.00E+5nMAssay Description:Binding affinity (Ki) against human phosphatidylinositol 4-kinaseMore data for this Ligand-Target Pair
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM11941(2,5-ADP | ADENOSINE-2 -5 -DIPHOSPHATE | {[(2R,3R,4...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367104(CHEMBL607646)
Affinity DataKi:  3.80E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase(Escherichia coli (strain K12))
TBA

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  4.50E+5nMAssay Description:Inhibition of inosine monophosphate dehydrogenase in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  5.80E+5nMAssay Description:Inhibitory activity against rat Adenylate kinase M isoenzyme in the presence of AMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367104(CHEMBL607646)
Affinity DataKi:  6.00E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027451(CHEMBL3143591 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  6.30E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367104(CHEMBL607646)
Affinity DataKi:  6.70E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367109(CHEMBL608484)
Affinity DataKi:  8.00E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367103(CHEMBL608483)
Affinity DataKi:  9.10E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027451(CHEMBL3143591 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  9.40E+5nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKi:  1.05E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367098(CHEMBL607630)
Affinity DataKi:  1.40E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027451(CHEMBL3143591 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  1.70E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367098(CHEMBL607630)
Affinity DataKi:  1.80E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase IIlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367098(CHEMBL607630)
Affinity DataKi:  2.10E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367109(CHEMBL608484)
Affinity DataKi:  2.10E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367107(CHEMBL3244493 | CHEMBL610643)
Affinity DataKi:  2.30E+6nMAssay Description:Competitive Inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367103(CHEMBL608483)
Affinity DataKi:  2.40E+6nMAssay Description:Non-competitive/Competitive inhibitory constant of compound with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367103(CHEMBL608483)
Affinity DataKi:  2.60E+6nMAssay Description:Non-competitive/Competitive inhibitory constant of compound with Rat adenylate kinase IIlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367102(CHEMBL608353)
Affinity DataKi:  3.10E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367045(CHEMBL605010)
Affinity DataKi:  3.20E+6nMAssay Description:Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367045(CHEMBL605010)
Affinity DataKi:  3.20E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027447(CHEMBL1229561 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  3.60E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367110(CHEMBL609073)
Affinity DataKi:  3.70E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367045(CHEMBL605010)
Affinity DataKi:  3.80E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027447(CHEMBL1229561 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  4.10E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367106(CHEMBL1230507 | CHEMBL609083)
Affinity DataKi:  4.20E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367045(CHEMBL605010)
Affinity DataKi:  4.50E+6nMAssay Description:Inhibitory activity against rat Adenylate kinase M isoenzyme was determined in the presence of ATP, non competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367045(CHEMBL605010)
Affinity DataKi:  4.50E+6nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367110(CHEMBL609073)
Affinity DataKi:  4.70E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50027447(CHEMBL1229561 | Phosphoric acid mono-[5-(6-amino-p...)
Affinity DataKi:  4.80E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367100(CHEMBL607942)
Affinity DataKi:  5.40E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367100(CHEMBL607942)
Affinity DataKi:  5.40E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367110(CHEMBL609073)
Affinity DataKi:  5.80E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKi:  6.30E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367041(CHEMBL603556)
Affinity DataKi:  9.80E+6nMAssay Description:Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367041(CHEMBL603556)
Affinity DataKi:  9.80E+6nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367041(CHEMBL603556)
Affinity DataKi:  1.00E+7nMAssay Description:Competitive inhibitory constant with Rat adenylate kinase IIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367100(CHEMBL607942)
Affinity DataKi:  1.10E+7nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367102(CHEMBL608353)
Affinity DataKi:  1.14E+7nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase II isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367089(CHEMBL1788163)
Affinity DataKi:  1.14E+7nMAssay Description:Non competitive binding inhibition constant (Ki) of rat adenylate kinase (AK II) isozymes was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367102(CHEMBL608353)
Affinity DataKi:  1.24E+7nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase IIlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367089(CHEMBL1788163)
Affinity DataKi:  1.24E+7nMAssay Description:Non competitive binding inhibition constant of rat aAdenylate kinase III was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase 2, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367088(CHEMBL1788161)
Affinity DataKi:  1.26E+7nMAssay Description:Non competitive binding inhibition constant (Ki) of rat adenylate kinase (AK II) isozymes was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTP:AMP phosphotransferase AK3, mitochondrial(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367088(CHEMBL1788161)
Affinity DataKi:  1.40E+7nMAssay Description:Non competitive binding inhibition of rat adenylate kinase IIl was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367041(CHEMBL603556)
Affinity DataKi:  1.60E+7nMAssay Description:Inhibitory activity against rat Adenylate kinase M isoenzyme was determined in the presence of ATP, non competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate kinase isoenzyme 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367041(CHEMBL603556)
Affinity DataKi:  1.60E+7nMAssay Description:Non-competitive inhibitory constant of compound with Rat adenylate kinase M isozymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  0.950nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cellsMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50085554(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Affinity DataIC50:  7.30nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  13nMAssay Description:Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluatedMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytesMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  100nMAssay Description:Inhibition of p60c-src expressed in chick embryo fibroblastMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
University Of Pavia

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  140nMAssay Description:Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrateMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  210nMAssay Description:Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2/3(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50:  263nMAssay Description:Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50013703((ADP)[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetra...)
Affinity DataIC50:  280nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  320nMAssay Description:Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062291(CHEMBL54116 | Phosphoric acid mono-[2-(6-methylami...)
Affinity DataIC50:  324nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  330nMAssay Description:Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  330nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  330nMAssay Description:Antagonist activity at P2Y1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  331nMAssay Description:In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  331nMAssay Description:Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghostsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  440nMAssay Description:Inhibition of FBPase in human liverMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  480nMAssay Description:Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataIC50:  500nMpH: 7.4 T: 2°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
University Of Pavia

Curated by ChEMBL
LigandPNGBDBM50318029(CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...)
Affinity DataIC50:  508nMAssay Description:Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50318029(CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...)
Affinity DataIC50:  508nMAssay Description:Antagonist activity at P2Y1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  660nMAssay Description:Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  740nMAssay Description:Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  800nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  980nMAssay Description:Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062276(CHEMBL55247 | Phosphoric acid mono-[5-(6-ethylamin...)
Affinity DataIC50:  1.08E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  1.15E+3nMAssay Description:Affinity at P2X purinoceptor 1 (P2X1) and the value is expressed as IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of P2X1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50:  1.29E+3nMAssay Description:Agonist activity at human P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Boston College

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Boston College

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometryMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  2.25E+3nMAssay Description:Antagonist activity at human platelet P2Y1 receptor assessed as inhibition of ADP-induced increase in cytosolic calcium level by FLUO-4 staining base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based a...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based spectrop...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isom...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coup...More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric me...More data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataIC50:  4.19E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataIC50:  5.76E+3nMAssay Description:In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataIC50:  5.76E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSensor protein kinase WalK(Staphylococcus aureus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataIC50:  7.19E+3nMAssay Description:Inhibition of Streptococcus pneumoniae VicK autophosphorylation using compound at non-aggregating concentration after 30 mins in presence of [gamma-3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-conjugating enzyme UBC9(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Affinity DataIC50:  7.95E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062282(CHEMBL58764 | Phosphoric acid mono-[2-(6-amino-pur...)
Affinity DataIC50:  8.46E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Affinity DataIC50:  8.72E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluc...More data for this Ligand-Target Pair
TargetEndoplasmin(Canis familiaris)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataIC50:  1.14E+4nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062285(CHEMBL292442 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataIC50:  1.24E+4nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  1.29E+4nMAssay Description:Inhibition of P2X3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataIC50:  1.29E+4nMAssay Description:Affinity at P2X purinoceptor 3 (P2X3) and the value is expressed as IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  1.32E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataIC50:  1.49E+4nMAssay Description:In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSUMO-activating enzyme subunit 1(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Affinity DataIC50:  1.66E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of EPAC2 (unknown origin)More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50:  4.00E+4nMAssay Description:Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assayMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062281(CHEMBL59090 | Phosphoric acid mono-[5-(6-dimethyla...)
Affinity DataIC50:  4.67E+4nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataIC50:  4.80E+4nMAssay Description:Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysisMore data for this Ligand-Target Pair
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataIC50:  5.56E+4nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50318030(((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...)
Affinity DataIC50: <1.00E+5nMAssay Description:Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Affinity DataIC50:  1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataIC50:  1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCyclic AMP receptor protein(Vibrio cholerae O1 biovar El Tor str. N16961)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM10851((4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihy...)
Affinity DataIC50:  1.30E+5nMMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50248004(CHEBI:63599 | Fludara | Fludarabine | Fludarabine ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Homo sapiens (Human))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataIC50:  1.45E+5nMAssay Description:Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding siteMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50024999(CHEMBL414948 | Sulfuric acid mono-{5-(6-amino-puri...)
Affinity DataIC50:  2.00E+5nMAssay Description:Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
Affinity DataIC50: >5.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol monophosphatase 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM11940(2-AMP | 2-Adenylic acid | Adenosine 2-monophosphat...)
Affinity DataIC50:  1.30E+6nMAssay Description:Tested for the inhibitory activity against bovine inositol monophosphatase by measuring concentration inhibiting the production of [14C]-inositol fro...More data for this Ligand-Target Pair
In DepthDetails Article
TargetRibose-phosphate pyrophosphokinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50280244(Phosphoric acid mono-[(2R,3R,4S,5R)-5-(6-amino-pur...)
Affinity DataIC50:  5.10E+6nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  1.52E+3nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd:  3.70E+3nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
TargetEndoplasmin(Canis familiaris)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of BODIPY-AG binding to dog Grp94More data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataKd:  109nMAssay Description:Binding affinity to human P2Y1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd: >5.00E+6nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM11941(2,5-ADP | ADENOSINE-2 -5 -DIPHOSPHATE | {[(2R,3R,4...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  6.50E+4nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 11(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  100nMAssay Description:Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 11(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  1.73E+4nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  7.20E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  3.70E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  3.70E+3nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  3.50E+3nMAssay Description:Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataKd:  282nMAssay Description:pA2 value was evaluated against P2Y purinoceptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50085554(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Affinity DataEC50:  0.150nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'pMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50152834(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)
Affinity DataEC50:  17nMAssay Description:Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd:  1.20E+5nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 resi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  4.10E+3nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 resi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  6.30E+4nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKd:  3.70E+5nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  1.49E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  200nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  300nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  200nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
TargetCyclic nucleotide-gated olfactory channel(Rattus norvegicus)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  5.31E+4nMAssay Description:Activation of recombinant rat CNGA2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch-clamp electrophysiology met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic nucleotide-gated olfactory channel(Rattus norvegicus)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  4.98E+3nMAssay Description:Activation of recombinant rat CNGA2/CNGA4/CNGB1b heterotetramer expressed in Xenopus laevis oocyte assessed as increase in current amplitude by patch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Mus musculus)
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  3.87E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to DEP domain deficient mouse EPAC2 (280 to 988 residues) measured after 5 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  5.62E+3nMAssay Description:Inhibition of 8Fluo-cAMP binding to recombinant human His-tagged EPAC1 (157 to 881 residues) expressed in Escherichia coli measured after 5 mins by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Hospital Jena

Curated by ChEMBL
LigandPNGBDBM50384264(CHEMBL316966)
Affinity DataKd:  4.50E+3nMAssay Description:Binding affinity to GST-tagged human EPAC1 CNBD (149 to 318 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by 8-NBD-cAMP ba...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Nanjing University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of protein kinase C epsilon expressed in Sf-9 cellsMore data for this Ligand-Target Pair
TargetEndoplasmin(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50552885(CHEBI:16771 | CHEMBL583986)
Affinity DataKd: >5.00E+4nMAssay Description:Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50552885(CHEBI:16771 | CHEMBL583986)
Affinity DataKd: >5.00E+4nMAssay Description:Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525923(US11185100, TABLE 6.1)
Affinity DataEC50:  2.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525923(US11185100, TABLE 6.1)
Affinity DataEC50:  2.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525952(US11185100, TABLE 6.5)
Affinity DataEC50: >1.00E+6nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525952(US11185100, TABLE 6.5)
Affinity DataEC50: >1.00E+6nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525952(US11185100, TABLE 6.5)
Affinity DataEC50:  7.20E+5nMAssay Description:The concentration of IMP is 0.2 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525952(US11185100, TABLE 6.5)
Affinity DataEC50: >1.00E+6nMAssay Description:The concentration of alanine is 20 mM, and the concentration of IMP is 0.2 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  1.00E+3nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50: >1.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50: >1.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50: >1.00E+4nMAssay Description:The concentration of IMP is 0.2 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50: >3.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  3.00E+3nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50: >3.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  3.00E+3nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  1.00E+3nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526098(US11185100, TABLE 7.2)
Affinity DataEC50:  1.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  1.10E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526139(US11185100, TABLE 7.5)
Affinity DataEC50:  5.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526148(US11185100, TABLE 7.6)
Affinity DataEC50:  2.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526200(US11185100, TABLE 7.8)
Affinity DataEC50:  5.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526234(US11185100, TABLE 7.14)
Affinity DataEC50: >1.00E+6nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  260nMAssay Description:Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activati...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509429(CHEBI:71578 | CHEMBL1229884)
Affinity DataEC50:  51nMAssay Description:Agonist activity at STING (unknown origin)More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein(Human)
Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences And Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50587690(CHEMBL5169585)
Affinity DataEC50:  51nMAssay Description:Agonist activity at STING (unknown origin) in THP1-Blue ISG cells assessed as type I interferon production levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKd:  500nMpH: 7.4 T: 2°CAssay Description:All experiments were performed on a Biacore T100 at 25 deg C with a flow rate of 30 uL per minute. Double His-tagged HSP70 was immobilised on the sur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bos taurus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81287(6-(6-aminopurin-9-yl)-2-ethoxy-2-oxidanylidene-4a,...)
Affinity DataEC50:  2.68E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bos taurus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  68.0nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type II-beta regulatory subunit(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81287(6-(6-aminopurin-9-yl)-2-ethoxy-2-oxidanylidene-4a,...)
Affinity DataEC50:  3.75E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type II-beta regulatory subunit(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  88.5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type II-beta regulatory subunit(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81287(6-(6-aminopurin-9-yl)-2-ethoxy-2-oxidanylidene-4a,...)
Affinity DataEC50:  3.75E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type II-beta regulatory subunit(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  88.5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bos taurus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81287(6-(6-aminopurin-9-yl)-2-ethoxy-2-oxidanylidene-4a,...)
Affinity DataEC50:  2.68E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetcAMP-dependent protein kinase type I-alpha regulatory subunit(Bos taurus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM81289(Adenosine 3',5'-cyclic monophosphate sodiu...)
Affinity DataEC50:  68.0nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEndoplasmic reticulum chaperone BiP(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKd:  2.17E+3nM Kon:  0.00500M-1s-1pH: 7.4 T: 2°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM82124(adenosine-derived inhibitor (Grp78), 1)
Affinity DataKd:  500nMpH: 7.4 T: 2°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
Affinity DataKd:  6.50E+5nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataKon:  0.00488M-1s-1Assay Description:Association rate constant for the interaction between inhibitor and HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062282(CHEMBL58764 | Phosphoric acid mono-[2-(6-amino-pur...)
Affinity DataEC50:  1.37E+3nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062285(CHEMBL292442 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  1.29E+4nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  1.28E+3nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  6.26E+3nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50421415(CHEMBL414948)
Affinity DataEC50:  0.210nMAssay Description:Binding affinity of compound to human recombinant Ribonuclease L was evaluatedMore data for this Ligand-Target Pair
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50085554(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Affinity DataEC50:  0.200nMAssay Description:Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  8.00E+3nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50:  330nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHPr kinase/phosphorylase(Bacillus subtilis)
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataEC50:  4.30E+6nMAssay Description:Inhibition of histidine containing protein in kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189858(CHEMBL434553 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  393nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189859(CHEMBL427600 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  0.900nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189860(CHEMBL261902 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  323nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189861(CHEMBL424746 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  1.30nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189863(CHEMBL439290 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  396nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50189862(CHEMBL414569 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataEC50:  3.60nMAssay Description:Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataEC50:  1.20E+5nMAssay Description:Displacement of cy3B-GM from Hsp90alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 11(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  24nMAssay Description:Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50183322(CHEMBL601940)
Affinity DataEC50:  13nMAssay Description:Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  324nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataKd:  320nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataEC50:  14nMAssay Description:Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-5A-dependent ribonuclease(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50152834(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)
Affinity DataEC50:  9.70nMAssay Description:Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock cognate 71 kDa protein(Bos taurus)
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKd:  110nMAssay Description:Binding affinity to bovine Hsc70 by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM31995(ADP | Adenosine Diphosphate (ADP) | CHEMBL14830)
Affinity DataKd:  260nMAssay Description:Binding affinity to human Hsc70 by isothermal calorimetry assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  6.29E+3nMAssay Description:Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reachedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Affinity DataEC50:  2.34E+3nMAssay Description:Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reachedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50370075(CHEMBL610931)
Affinity DataEC50:  1.90E+4nMAssay Description:Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50:  1.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant human receptor P2X purinoceptor 2 (P2X2 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 2(RAT)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 6(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 2(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 4(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50:  1.15E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  1.10E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(CHEMBL129841 | MRS 2179)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(RAT)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  2.80E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 5(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  1.80E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADENOSINE DIPHOSPHATE | ADP)
Affinity DataEC50:  69nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50395133(CHEMBL2163559)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50395134(CHEMBL2163558)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50395135(CHEMBL576739)
Affinity DataEC50:  440nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM11940(2-AMP | 2-Adenylic acid | Adenosine 2-monophosphat...)
Affinity DataEC50:  490nMAssay Description:Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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