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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078872(CHEMBL3416353)
Affinity DataIC50:  310nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078871(CHEMBL3416352)
Affinity DataIC50:  450nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation pre-incubated for 15 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078872(CHEMBL3416353)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078871(CHEMBL3416352)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human blood PMNL assessed as reduction in lipoxygenase products formation in presence of arachidonic acid pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078872(CHEMBL3416353)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase(Schistosoma mansoni)
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50505498(CHEBI:31687 | Idebenone | Raxone)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells using ZMAL as substrate af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078871(CHEMBL3416352)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-expressed gene 1 protein(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078871(CHEMBL3416352)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50505498(CHEBI:31687 | Idebenone | Raxone)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-expressed gene 1 protein(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50078872(CHEMBL3416353)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mPGES1 in IL-1beta stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 synthase activity after 15 mins using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Naples

Curated by ChEMBL
LigandPNGBDBM50505498(CHEBI:31687 | Idebenone | Raxone)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM50505498(CHEBI:31687 | Idebenone | Raxone)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of N-terminal His6 tagged human sirtuin 2 (25 to 389 residues) using Cbz-Lys(acetyl)-AMC as substrate after 4 hrs in presence of NAD+ by h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed