Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 72 hits in this display
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM87330(MLS000766234 | SMR000528847 | TENIPOSIDE | cid_539...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM87330(MLS000766234 | SMR000528847 | TENIPOSIDE | cid_539...)
BDBM87330(MLS000766234 | SMR000528847 | TENIPOSIDE | cid_539...)
BDBM87330(MLS000766234 | SMR000528847 | TENIPOSIDE | cid_539...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 2.48E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >1.20E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
BDBM50248198(Teniposide | VM-26 | Vumon)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 2.82E+4nMAssay Description:Inhibition of human DNA topoisomerase-2alpha assessed as relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 3.38E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alpha using plasmid pNO1 substrate incubated at 37 degC for 30 mins by fluorimetryMore data for this Ligand-Target Pair
BDBM50248198(Teniposide | VM-26 | Vumon)
BDBM87330(MLS000766234 | SMR000528847 | TENIPOSIDE | cid_539...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >3.59E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 3.80E+4nMAssay Description:In vitro activity against mammalian topoisomerase II measured as ATP-dependent unknotting of P4 DNA compared to enzyme and DNA controlMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 5.60E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast plasmid DNA by fluorescent plate readerMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >6.00E+4nMAssay Description:Drug concentration needed to produce a 50% reduction of bovine brain tubulin polymerization relative to the controlMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: 6.03E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
BDBM50248198(Teniposide | VM-26 | Vumon)
IC50: 6.27E+4nMAssay Description:Poison activity at topoisomerase-2 in human HepG2 cell lysate assessed as topoisomerase-2 band depletion after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Integrase(Human immunodeficiency virus 1)Sapienza University Of Rome
Curated by ChEMBL
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
BDBM50248198(Teniposide | VM-26 | Vumon)
BDBM50248198(Teniposide | VM-26 | Vumon)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
IC50: >3.50E+5nMpH: 7.8 T: 2°CAssay Description:Supercoiled pHOT1 DNA (0.5 μg) was incubated with four units of human topoisomerase I in relaxation buffer (10mM Tris-HCl (pH 7.8), 1mM EDTA, 0.15...More data for this Ligand-Target Pair
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
BDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
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