Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 81 hits in this display
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13088(2-[(4-butoxybenzene)(2-methylpropyl)sulfonamido]-N...)
BDBM13088(2-[(4-butoxybenzene)(2-methylpropyl)sulfonamido]-N...)
BDBM13099(2-[(cyclohexylmethyl)(4-methoxybenzene)sulfonamido...)
BDBM13090(2-{[4-(hexyloxy)benzene](2-methylpropyl)sulfonamid...)
BDBM13090(2-{[4-(hexyloxy)benzene](2-methylpropyl)sulfonamid...)
Ki: 63nM ΔG°: -42.8kJ/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13089(CGS 27023A Analog 17 | N-hydroxy-2-{[4-(3-methylbu...)
Ki: 78nM ΔG°: -42.2kJ/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13089(CGS 27023A Analog 17 | N-hydroxy-2-{[4-(3-methylbu...)
BDBM13098(CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenz...)
Ki: 94nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Ki: 133nM ΔG°: -40.8kJ/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13092(CGS 27023A Analog 20 | N-hydroxy-2-[(2-methylpropy...)
Ki: 336nM ΔG°: -38.4kJ/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13092(CGS 27023A Analog 20 | N-hydroxy-2-[(2-methylpropy...)
BDBM13093(2-{[4-(2-ethoxyethoxy)benzene](2-methylpropyl)sulf...)
BDBM13093(2-{[4-(2-ethoxyethoxy)benzene](2-methylpropyl)sulf...)
Ki: 1.13E+3nM ΔG°: -35.3kJ/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13102(2-[butan-2-yl(4-methoxybenzene)sulfonamido]-N-hydr...)
Ki: 1.82E+3nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Ki: 7.40E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Ki: 7.40E+3nMAssay Description:Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrateMore data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
IC50: 0.590nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-PLGLDpaAR fluorescent substrate incubated for 2 hrs by microplate reader methodMore data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
IC50: 5.20nMAssay Description:Inhibition of MMP13 (unknown origin) assessed as reduction in cleavage of colorimetric substrate incubated for 1 hr by colorimetric analysisMore data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM50078567((S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfon...)
BDBM50104003(CHEMBL105142 | N-Hydroxy-2-[isobutyl-(4-methoxy-be...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM50078567((S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfon...)
BDBM50104003(CHEMBL105142 | N-Hydroxy-2-[isobutyl-(4-methoxy-be...)
BDBM50078567((S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfon...)
BDBM50104003(CHEMBL105142 | N-Hydroxy-2-[isobutyl-(4-methoxy-be...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM50104003(CHEMBL105142 | N-Hydroxy-2-[isobutyl-(4-methoxy-be...)
BDBM50078567((S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfon...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM634008(US20230357139, Compound Z)
IC50: 246nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM633985(US20230357139, Compound C)
IC50: 372nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM50078567((S)-N-Hydroxy-2-[isobutyl-(4-methoxy-benzenesulfon...)
BDBM50104003(CHEMBL105142 | N-Hydroxy-2-[isobutyl-(4-methoxy-be...)
BDBM633989(US20230357139, Compound G)
IC50: 443nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM633986(US20230357139, Compound D)
IC50: 489nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM13092(CGS 27023A Analog 20 | N-hydroxy-2-[(2-methylpropy...)
IC50: 1.21E+3nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM634009(US20230357139, Compound AA)
IC50: 1.69E+3nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM634000(US20230357139, Compound R)
IC50: 2.42E+3nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
BDBM634003(US20230357139, Compound U)
IC50: 8.53E+3nMAssay Description:Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...More data for this Ligand-Target Pair
BDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
IC50: 1.71E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
IC50: 3.12E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
IC50: 3.75E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM13098(CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenz...)
IC50: 3.88E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
BDBM633989(US20230357139, Compound G)
IC50: >1.00E+5nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
BDBM633986(US20230357139, Compound D)
IC50: >1.00E+5nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
BDBM633985(US20230357139, Compound C)
IC50: >1.00E+5nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
BDBM13092(CGS 27023A Analog 20 | N-hydroxy-2-[(2-methylpropy...)
IC50: >1.00E+5nMAssay Description:Gelatinase E (Gel E) was purified from bacterial culture supernatant from E. faecalis. E. faecalis was cultured aerobically in Todd Hewitt Broth over...More data for this Ligand-Target Pair
Elastase(Pseudomonas aeruginosa)Uit The Arctic University Of Norway
Curated by ChEMBL
BDBM50314228((R)-N-hydroxy-2-(N-isobutyl-4-methoxyphenylsulfona...)
BDBM13102(2-[butan-2-yl(4-methoxybenzene)sulfonamido]-N-hydr...)
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