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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
42
hits in this display
Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 41nM
Assay Description:
Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Ki: 47nM
Assay Description:
Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Biota
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
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Affinity Data
Ki: 91nM
Assay Description:
Inhibitory constant against HIV-1 reverse transcriptase
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50118628
((R)-1-((R)-4-Azido-5-methylphosphate-tetrahydro-fu...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
Compound was tested for binding affinity against Mycobacterium tuberculosis thymidine monophosphate kinase
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50118628
((R)-1-((R)-4-Azido-5-methylphosphate-tetrahydro-fu...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm)
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50118628
((R)-1-((R)-4-Azido-5-methylphosphate-tetrahydro-fu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+4nM
Assay Description:
Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis
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Target
Thymidylate kinase
(Mycobacterium tuberculosis)
Ghent University
Curated by
ChEMBL
Ligand
BDBM50118628
((R)-1-((R)-4-Azido-5-methylphosphate-tetrahydro-fu...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+4nM
Assay Description:
Competitive inhibition of Mycobacterium tuberculosis TMPK expressed in Escherichia coli NM554 by coupled spectrophotometric assay
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Biota
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
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Affinity Data
IC50: 3nM
Assay Description:
Tested against HIV-1 reverse transcriptase (HIV-1 RT) with poly(rA)/(dT)12-18 as template and [methyl-3H]-dTTP as competing substrate
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Biota
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 22nM
Assay Description:
Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT) obtained from HIV-1-infected H9 cell cultures
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Biota
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 43nM
Assay Description:
Inhibitory activity against HIV-1 reverse transcriptase
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 54nM
Assay Description:
Inhibition of HIV1 recombinant reverse transcriptase
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 80nM
Assay Description:
Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 300nM
Assay Description:
Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 320nM
Assay Description:
Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 360nM
Assay Description:
Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 420nM
Assay Description:
Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay
More data for this Ligand-Target Pair
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Target
Reverse transcriptase/RNaseH
(Human immunodeficiency virus 1)
Biota
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10E+3nM
Assay Description:
Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase
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Target
DNA polymerase delta catalytic subunit
(Homo sapiens (Human))
Pharmacia
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
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Affinity Data
IC50: 2.30E+3nM
pH: 7.5
Assay Description:
Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...
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Target
DNA polymerase catalytic subunit
(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Pharmacia
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.30E+3nM
pH: 7.5
Assay Description:
Inhibition of herpes simplex virus type 1 DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes a...
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Target
DNA polymerase catalytic subunit
(Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
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Affinity Data
IC50: 3.30E+3nM
Assay Description:
Inhibition of HSV1 DNA polymerase by scintillation proximity assay
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Target
DNA polymerase catalytic subunit
(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)
Pharmacia
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.80E+3nM
pH: 7.5
Assay Description:
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...
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Target
DNA polymerase catalytic subunit
(Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)
Pharmacia
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.80E+3nM
pH: 7.5
Assay Description:
Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.00E+3nM
Assay Description:
Inhibition of HIV1 reverse transcriptase using T19-Cy5 labeled 23-mer DNA/T2-TAMRA labeled 63-mer DNA as primer/template assessed as inhibition of dN...
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Target
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human))
Chulalongkorn University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
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Affinity Data
IC50: 1.10E+4nM
Assay Description:
Inhibition of DNA polymerase alpha
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Target
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human))
Chulalongkorn University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.34E+4nM
pH: 7.5
Assay Description:
Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...
More data for this Ligand-Target Pair
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Target
DNA polymerase beta
(Homo sapiens (Human))
Chulalongkorn University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of DNA polymerase beta
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Target
DNA polymerase catalytic subunit
(Human cytomegalovirus (HCMV strain AD169) )
Pfizer
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
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Affinity Data
IC50: 2.21E+4nM
Assay Description:
Inhibition of HCMV DNA polymerase by scintillation proximity assay
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Target
DNA polymerase catalytic subunit
(Human cytomegalovirus (HCMV strain AD169) )
Pfizer
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.21E+4nM
pH: 7.5
Assay Description:
Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
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Affinity Data
Kd: 21nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/K65R mutant assessed as ATP-mediated excision of zidovudine-monophosphate termina...
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.90E+3nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M184V mutant
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 20nM
Assay Description:
Binding affinity to wild type HIV1 LAI reverse transcriptase assessed as ATP-mediated excision of zidovudine-monophosphate terminated DNA/DNA templat...
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 3.50E+3nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 1.15E+3nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 1.99E+3nM
Assay Description:
Binding affinity to wild type HIV1 LAI reverse transcriptase
More data for this Ligand-Target Pair
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Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.00E+3nM
Assay Description:
Binding affinity to HIV1 reverse transcriptase
More data for this Ligand-Target Pair
Target Info
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MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
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Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: >6.00E+4nM
Assay Description:
Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
Purchase
KEGG
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50370476
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Copy SMILES
Copy InChI
Affinity Data
Kd: 5.50E+4nM
Assay Description:
Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
Purchase
KEGG
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 2.49E+4nM
Assay Description:
Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 77nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M184V mutant assessed as ATP-mediated excision of zidovudine-monophosphate terminated DNA/DNA temp...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 19nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant assessed as ATP-mediated excision of zidovudine-monophosphate terminated D...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Reverse transcriptase protein
(Human immunodeficiency virus 1)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50478975
(AZIDOTHYMIDINE MONOPHOSPHATE | Zidovudine Monophos...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 98nM
Assay Description:
Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant assessed as ATP-mediated excision of zidovudine-monophosphate termin...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
PubMed
Copy BDB DOI