Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetThymidylate synthase(Mus musculus)
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50094622(1-(beta--D-2-Deoxyribofuranosyl)-4-hydroxyamino-5-...)
Affinity DataKi:  1.91E+3nMAssay Description:Time-independent inhibition of thymidylate synthase from parenteral L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50094622(1-(beta--D-2-Deoxyribofuranosyl)-4-hydroxyamino-5-...)
Affinity DataKi:  2.18E+3nMAssay Description:Time-independent inhibition of thymidylate synthase from FdUrd-resistant L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Rattus norvegicus)
University Of Colorado

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  6.40E+4nMAssay Description:Inhibitory activity evaluated against alpha-2,6-sialyltransferase from rat liverMore data for this Ligand-Target Pair
TargetCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase(Rattus norvegicus)
University Of Colorado

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  6.50E+4nMAssay Description:Inhibitory activity evaluated against alpha-2,3-sialyltransferase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50421668(CHEMBL2311177)
Affinity DataKi:  1.20E+5nMAssay Description:Compound was evaluated for the inhibition of dTMP synthetase with respect to dUMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonuclease pancreatic(Bison bison (American bison))
National Hellenic Research Foundation

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  8.44E+5nMpH: 6.0Assay Description:Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrotidine 5'-phosphate decarboxylase(Methanobacterium thermoautotrophicum)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  1.20E+6nMAssay Description:Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine 5'-monophosphate synthase(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  1.40E+6nMAssay Description:Inhibition of human ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeminal ribonuclease(Bos taurus)
National Hellenic Research Foundation

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi:  1.56E+6nMpH: 6.0Assay Description:Inhibition of bovine seminal ribonuclease assessed as enzyme activity by spectrophotometric method at pH 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrotidine-5'-phosphate decarboxylase(Plasmodium falciparum (malaria parasite P. falcipa...)
University Health Network

Curated by ChEMBL
LigandPNGBDBM50310540(((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)...)
Affinity DataKi: >1.00E+7nMAssay Description:Inhibition of Plasmodium falciparum ODCase by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526260(US11185100, TABLE 13.1)
Affinity DataEC50:  5.70E+6nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
University Of Dundee

LigandPNGBDBM31913(1-beta-D-arabinofuranosylcytosine 5-monophosphate ...)
Affinity DataKd:  1.89E+7nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair