Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 54 hits in this display   

TargetAurora kinase A(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  11nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  31nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8050(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 21 | 3...)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8040(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 11 | 4...)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataKi:  140nM ΔG°:  -39.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  168nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8050(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 21 | 3...)
Affinity DataKi:  210nM ΔG°:  -38.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  220nM ΔG°:  -38.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  239nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  243nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  251nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  286nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataKi:  320nM ΔG°:  -37.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  337nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  348nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8064(1-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  400nM ΔG°:  -37.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  575nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  666nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  706nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  769nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  807nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  840nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  909nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  960nM ΔG°:  -34.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  2.52E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataKi:  2.56E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8040(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 11 | 4...)
Affinity DataKi:  2.60E+3nM ΔG°:  -32.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataKi:  4.01E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319625(CHEMBL1083150 | N1-(4-(2,4-Dimethylthiazol-5-yl)py...)
Affinity DataKi:  4.24E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8064(1-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  1.06E+4nM ΔG°:  -28.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataIC50:  220nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8066(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 37 | 4...)
Affinity DataIC50:  220nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
TargetG1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataIC50:  230nMAssay Description:In vitro kinase inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM50319624(Aminopyrimidine, 4 | CHEMBL1084454 | N1-(4-(2,4-Di...)
Affinity DataIC50:  3.80E+3nMAssay Description:In vitro kinase inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Cambridge

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataIC50:  5.00E+3nMpH: 7.5 T: 2°CAssay Description:D. melanogaster Polo kinase assays were performed as previously described40, using baculovirus-expressed Polo kinase. Enzyme was immunoprecipitated u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Cambridge

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKon:  0.0290M-1s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  1.43E+3nMAssay Description:OctetRed_Method1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKoff:  6.43E+4s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKon:  0.0770M-1s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  4.78E+3nMpH: 7.5 T: 2°CAssay Description:ThermofluorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  121nMAssay Description:OctetRed_Method2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  121nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKd:  1.43E+3nMpH: 7.5 T: 2°CAssay Description:OctetRedMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKoff:  2.42E+5s-1Assay Description:OctetRed_Method3More data for this Ligand-Target Pair
In DepthDetails PubMed
Displayed 1 to 50 (of 54 total ) | Next | Last >>