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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 13 hits in this display   

TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352165(LYSINE)
Affinity DataKi:  5.46E+4nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoleucine--tRNA ligase(Escherichia coli)
Gesellschaft Fur Molekularbiolische Forschung Mbh

LigandPNGBDBM18139((2S)-2-aminoheptanoic acid | L-2-Amino-heptanoic a...)
Affinity DataKi:  1.67E+7nM ΔG°:  -9.98kJ/molepH: 7.5 T: 2°CAssay Description:Utilizing an analytical ultracentrifuge, the binding constants of various amino acids and isoleucine analogues to IleRS were estimated from their com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional aspartokinase/homoserine dehydrogenase 1(Escherichia coli)
University Of Akron

LigandPNGBDBM92991(L-norleucine)
Affinity DataKi:  2.40E+7nMAssay Description:Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352165(LYSINE)
Affinity DataIC50:  6.12E+4nMAssay Description:Inhibition of human erythrocyte Glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052549(2-Amino-heptanedioic acid | CHEMBL111050)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052549(2-Amino-heptanedioic acid | CHEMBL111050)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu1-alpha receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052552(2-Amino-octanedioic acid | CHEMBL320957)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052552(2-Amino-octanedioic acid | CHEMBL320957)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052549(2-Amino-heptanedioic acid | CHEMBL111050)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50354832(CHEMBL1834160)
Affinity DataKd:  6.00E+4nMAssay Description:Displacement of [14C-guanidino]-L-arginine from human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAPC family lysine-specific permease(Salmonella typhimurium)
Max Planck Institute Of Biophysics

LigandPNGBDBM217368((2R)-2,6-diaminohexanoic acid | D-Lysine)
Affinity DataKd:  1.80E+6nMpH: 5.9 T: 2°CAssay Description:ITC measurements were carried out at 20 °C with a VP-ITC calorimeter (GE Healthcare, MicroCal, Inc.) consisting of a 1.45-ml reaction cell. STM2200 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAPC family lysine-specific permease(Salmonella typhimurium)
Max Planck Institute Of Biophysics

LigandPNGBDBM217367((2S)-2,6-diaminohexanoic acid | L-Lysine)
Affinity DataKd:  4.00E+4nMpH: 5.9 T: 2°CAssay Description:ITC measurements were carried out at 20 °C with a VP-ITC calorimeter (GE Healthcare, MicroCal, Inc.) consisting of a 1.45-ml reaction cell. STM2200 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052552(2-Amino-octanedioic acid | CHEMBL320957)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonistic activity at mGlu1-alpha receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed