Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 23 hits in this display   

TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to human arginase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase(Schistosoma mansoni (flatworms))
University Of Pennsylvania

LigandPNGBDBM130378(2(S)-amino-6-boronohexanoic acid (ABH))
Affinity DataKi:  1.80E+3nMpH: 8.5Assay Description:Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase(Plasmodium falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  311nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  311nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  800nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Rattus norvegicus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  800nMAssay Description:Inhibition of rat Arg1 at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human arginase 1 using L-arginine as substrate measured after 60 mins in presence of manganese chloride by o-phthaldialdehy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50427901(CHEMBL2326088)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of human Arg2 by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50427901(CHEMBL2326088)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  2.15E+3nMAssay Description:Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50427901(CHEMBL2326088)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of human arginase 1 transfected in CHO cells assessed as inhibition of urea formation after 24 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataIC50:  1.68E+4nMAssay Description:Inhibition of recombinant human ARG1 expressed in CHO-K1 cells assessed as reduction in urea level incubated for 24 hrs by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human Arg1 at pH 8.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase(Plasmodium falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to Plasmodium falciparum arginaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  18nMAssay Description:Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Affinity DataKd:  5nMAssay Description:Binding affinity to human arginase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase(Schistosoma mansoni (flatworms))
University Of Pennsylvania

LigandPNGBDBM130378(2(S)-amino-6-boronohexanoic acid (ABH))
Affinity DataKd:  1.30E+3nMpH: 8.5Assay Description:SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed