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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Serine racemase
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
Ki: 3.66E+5nM
Assay Description:
Binding affinity to serine recemase (unknown origin)
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Target
Proton-coupled amino acid transporter 1
(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
Ki: 5.10E+6nM
Assay Description:
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting
Checked by Author
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Target
Glutamate receptor ionotropic, NMDA 1
(RAT)
Institut De Recherches Servier
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: 250nM
Assay Description:
In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor
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Target
Glutamate receptor ionotropic, NMDA 1
(RAT)
Institut De Recherches Servier
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: 6.20E+3nM
Assay Description:
Inhibitory concentration of the compound required to inhibit [3H]-strychnine binding to N-methyl-D-aspartate glutamate receptor 1
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Target
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human))
Vanderbilt University Medical Center
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: 3.16E+4nM
Assay Description:
Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake
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Target
Large neutral amino acids transporter small subunit 1
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...
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Target
Sodium- and chloride-dependent GABA transporter 3
(Mus musculus)
Ludwig-Maximilians-University Munich
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: 1.35E+6nM
Assay Description:
Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells
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Target
Sodium- and chloride-dependent GABA transporter 2
(Mus musculus)
Ludwig-Maximilians-University Munich
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
IC50: 2.24E+6nM
Assay Description:
Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells
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Target
Glutamate receptor ionotropic, NMDA 1/2D
(RAT)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
EC50: 91nM
Assay Description:
Agonist activity at rat GluN1/GluN2D NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...
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Target
Glycine receptor subunit alpha-1
(Homo sapiens (Human))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
EC50: 9.55E+4nM
Assay Description:
Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay
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Target
Glutamate receptor ionotropic, NMDA 1/2A
(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
EC50: 990nM
Assay Description:
Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...
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Target
Glutamate receptor ionotropic, NMDA 1/2B
(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
EC50: 240nM
Assay Description:
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...
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Target
Glutamate receptor ionotropic, NMDA 1/2C
(RAT)
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM18133
(2-aminoacetic acid | CHEMBL773 | Glycine | [14C]Gl...)
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Affinity Data
EC50: 210nM
Assay Description:
Agonist activity at rat GluN1/GluN2C NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...
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