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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 41 hits in this display   

TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Affinity DataKi:  5nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50432380(CHEMBL2348439)
Affinity DataKi:  7.10nMAssay Description:Inhibition of tumor-associated transmembrane human carbonic anhydrase-12 after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50432379(CHEMBL2348438)
Affinity DataKi:  9.40nMAssay Description:Inhibition of tumor-associated transmembrane human carbonic anhydrase-12 after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Affinity DataKi:  10.1nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Affinity DataKi:  10.3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mus musculus (mouse))
Universita Degli Studi Di Firenze

LigandPNGBDBM16650(N-(4-sulfamoylphenyl)hexanamide | aromatic sulfona...)
Affinity DataKi:  18nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50432380(CHEMBL2348439)
Affinity DataKi:  51nMAssay Description:Inhibition of tumor-associated transmembrane human carbonic anhydrase-9 after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Affinity DataKi:  53nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Affinity DataKi:  54nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Affinity DataKi:  54nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50432379(CHEMBL2348438)
Affinity DataKi:  57nMAssay Description:Inhibition of tumor-associated transmembrane human carbonic anhydrase-9 after 15 mins by Stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16650(N-(4-sulfamoylphenyl)hexanamide | aromatic sulfona...)
Affinity DataKi:  63nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Affinity DataKi:  66nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Affinity DataKi:  70nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50493439(CHEMBL2430111)
Affinity DataKi:  78nMAssay Description:Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Affinity DataKi:  78nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50493439(CHEMBL2430111)
Affinity DataKi:  96nMAssay Description:Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Affinity DataKi:  101nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Affinity DataKi:  106nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Affinity DataKi:  142nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345211(2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | CHE...)
Affinity DataKi:  190nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345213(2-Propyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide...)
Affinity DataKi:  233nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50108582(2-Propyl-pentanoic acid (4-sulfamoyl-phenyl)-amide...)
Affinity DataKi:  240nMAssay Description:Inhibitory effect on human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345211(2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | CHE...)
Affinity DataKi:  581nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345213(2-Propyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide...)
Affinity DataKi:  610nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50108582(2-Propyl-pentanoic acid (4-sulfamoyl-phenyl)-amide...)
Affinity DataKi:  630nMAssay Description:Inhibitory effect on bovine Carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345211(2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | CHE...)
Affinity DataKi:  682nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM16650(N-(4-sulfamoylphenyl)hexanamide | aromatic sulfona...)
Affinity DataKi:  980nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345211(2-isopropyl-N-(4-sulfamoylphenyl)pentanamide | CHE...)
Affinity DataKi:  1.85E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Affinity DataKi:  3.83E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345213(2-Propyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide...)
Affinity DataKi:  4.26E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345213(2-Propyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide...)
Affinity DataKi:  5.15E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16650(N-(4-sulfamoylphenyl)hexanamide | aromatic sulfona...)
Affinity DataKi:  1.42E+4nM ΔG°:  -27.7kJ/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50108582(2-Propyl-pentanoic acid (4-sulfamoyl-phenyl)-amide...)
Affinity DataKi:  2.25E+4nMAssay Description:Inhibitory effect on human carbonic anhydrase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed