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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 37 hits in this display   

TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50023905(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50002473(5-Amino-2-{4-[(2-amino-4-oxo-3,4-dihydro-pteridin-...)
Affinity DataKi:  5.90E+3nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50002473(5-Amino-2-{4-[(2-amino-4-oxo-3,4-dihydro-pteridin-...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50002473(5-Amino-2-{4-[(2-amino-4-oxo-3,4-dihydro-pteridin-...)
Affinity DataKi:  5.90E+3nMAssay Description:Binding affinity of the compound for hog liver Folyl-polyglutamate synthase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50020108(5-Amino-2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmeth...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from hogMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50515489(CHEMBL4472009)
Affinity DataKi:  9.76E+3nMAssay Description:Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50515489(CHEMBL4472009)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
"Magna Gr£Cia" University Of Catanzaro

Curated by ChEMBL
LigandPNGBDBM50515489(CHEMBL4472009)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1A3(Rattus norvegicus)
Kyoto University Hospital

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKi:  1.41E+4nMAssay Description:TP_TRANSPORTER: inhibition of MTX uptake in OAT-K1-expressing MDCK cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080004(CHEMBL3415968)
Affinity DataIC50:  132nMAssay Description:Inhibition of His-tagged HDAC6 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080002(CHEMBL3415970)
Affinity DataIC50:  179nMAssay Description:Inhibition of His-tagged HDAC6 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080003(CHEMBL3415969)
Affinity DataIC50:  193nMAssay Description:Inhibition of His-tagged HDAC6 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080002(CHEMBL3415970)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of His-tagged HDAC8 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080004(CHEMBL3415968)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of His-tagged HDAC1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080003(CHEMBL3415969)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of His-tagged HDAC1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080003(CHEMBL3415969)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of His-tagged HDAC8 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080004(CHEMBL3415968)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of His-tagged HDAC8 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080002(CHEMBL3415970)
Affinity DataIC50:  2.76E+3nMAssay Description:Inhibition of His-tagged HDAC1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  3.90E+3nMAssay Description:The compound was tested for its inhibitory activity (IC50) against thymidylate synthase(TS) derived from L. caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50023906(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  3.90E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50023906(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  5.50E+3nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50080009(CHEMBL3415967)
Affinity DataIC50:  8.05E+3nMAssay Description:Inhibition of His-tagged HDAC6 (unknown origin) expressed in Escherichia coli BL21(DE3) after 60 mins by MALDI mass spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against dihydrofolate reductase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataIC50:  2.90E+5nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  3.90E+5nMAssay Description:Inhibitory activity against thymidylate synthase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022281(2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-meth...)
Affinity DataIC50:  6.60E+5nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50:  7.50E+5nMAssay Description:Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50237629(Bio Science | CHEBI:27470 | Folacin | Folic Acid |...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50022281(2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-meth...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50237629(Bio Science | CHEBI:27470 | Folacin | Folic Acid |...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf21 cell membrane vesicles assessed as reduction in ATP-dependent [3H]-tauroc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50008291(2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylmeth...)
Affinity DataIC50: >3.00E+6nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKd:  4.40E+3nMpH: 7.0Assay Description:Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKd:  4.80E+3nMpH: 7.0 T: 2°CAssay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50367343((2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl...)
Affinity DataKd:  810nMpH: 7.0Assay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed