Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 49 hits in this display   

TargetCholecystokinin(RAT)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholecystokinin(RAT)
F. Hoffmann-La Roche

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50010318(CHEBI:17345 | CHEMBL283807)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibition of human HGPRTMore data for this Ligand-Target Pair
TargetPituitary adenylate cyclase-activating polypeptide(RAT)
Georg-August-University

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2'-deoxynucleoside 5'-phosphate N-hydrolase 1(Rattus norvegicus (Rat))
Institut Pasteur

LigandPNGBDBM92537(GMP)
Affinity DataKi:  2.00E+4nMAssay Description:Rcl inhibition by nucleotides.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi:  2.78E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInosine-5'-monophosphate dehydrogenase 1/2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50326433(((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataKi:  3.80E+4nMAssay Description:Ability to inhibit Inosine-5'-monophosphate dehydrogenase isolated from Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi:  8.51E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransmembrane and immunoglobulin domain-containing 3(RAT)
National Institute Of Diabetes, Digestive And Kidney Diseases

Curated by PDSP Ki Database
LigandPNGBDBM81822(CAS_6804 | GMP | Guanosine | NSC_6804)
Affinity DataKi:  9.85E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50010318(CHEBI:17345 | CHEMBL283807)
Affinity DataKi:  1.50E+6nMAssay Description:Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Linew...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604555(CHEMBL5181746)
Affinity DataIC50:  2.90nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50604557(CHEMBL5191008)
Affinity DataIC50:  4.20nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRocR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataIC50:  20nMAssay Description:Competitive binding affinity to Pseudomonas aeruginosa PAO1 His6-tagged RocR expressed in Escherichia coli BL21 (DE3) after 5 mins in presence of [32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein [139-379, H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM577474(US11472830, Cpd No. 6)
Affinity DataIC50:  23nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′, 3′cGAMP (cyclic (guanosine-(2′→5′)-monop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Bos taurus)
Kyowa Hakka

Curated by ChEMBL
LigandPNGBDBM50369127(CHEMBL395336)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine arterial Phosphodiesterase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497155(CHEMBL3291362)
Affinity DataIC50:  380nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497157(CHEMBL3286448)
Affinity DataIC50:  480nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRocR(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50436160(CHEMBL2398347)
Affinity DataIC50:  6.41E+3nMAssay Description:Competitive binding affinity to Pseudomonas aeruginosa PAO1 His6-tagged RocR expressed in Escherichia coli BL21 (DE3) after 5 mins in presence of [32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497154(CHEMBL3286449)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50410172(CHEMBL2079724)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497154(CHEMBL3286449)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Idenix Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50497156(CHEMBL3291363)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of purified Hepatitis C virus NS5B polymerase S282T mutantMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50370491(CHEMBL611110)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50165117(2-amino-6-hydroxy-9-[(2R,4S,5R)-5-[(phosphinatooxy...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50:  1.10E+3nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
TargetAdenosine 5'-monophosphoramidase HINT1(Homo sapiens (Human))
Regents Of The University Of Minnesota

US Patent
LigandPNGBDBM426061(US10513520, Compound GMP | guanosine monophosphate)
Affinity DataKd:  6.70E+4nMAssay Description:ITC experiments were conducted on a MicroCal Auto-ITC200 system (GE Healthcare life sciences). All titration experiments were performed at 20° C. in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50:  4.50E+3nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50:  900nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50:  1.84E+5nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataKd:  1.21E+3nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
LigandPNGBDBM50552397(CHEMBL4750306)
Affinity DataKd:  9.65E+3nMAssay Description:Binding affinity to wild-type human STING-CTD (139-379) expressed in Escherichia coli BL21(D Escherichia ) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Rattus norvegicus)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50326433(((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataKd:  6.00E+4nMAssay Description:Binding affinity to mouse HINT1 by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM577474(US11472830, Cpd No. 6)
Affinity DataKd:  17nMAssay Description:Compounds were analyzed on an 5200 biacore SPR instrument (GE Healthcare). E.coli produced truncated STING protein was immobilized on a series S stre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM577474(US11472830, Cpd No. 6)
Affinity DataKd:  310nMAssay Description:Thermofluor.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573842((5R,7R,8R,12aR,14R,15R,15aS,18R)-7-(2-amino- 6-oxo...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573860(2-amino-9-[(5S,7R,8R,12aR,14R,15R,15aS)-14- (6-ami...)
Affinity DataEC50:  2.40nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM573998(2-amino-9- [(2aR,6aS,7R,8R,9aR,14R,14aS,15R)- 5,7,...)
Affinity DataEC50:  2.32E+3nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573842((5R,7R,8R,12aR,14R,15R,15aS,18R)-7-(2-amino- 6-oxo...)
Affinity DataEC50:  2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525941(US11185100, TABLE 6.3)
Affinity DataEC50:  7.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525941(US11185100, TABLE 6.3)
Affinity DataEC50:  1.40E+5nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525941(US11185100, TABLE 6.3)
Affinity DataEC50: >3.00E+6nMAssay Description:The concentration of IMP is 0.2 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM525941(US11185100, TABLE 6.3)
Affinity DataEC50: >3.00E+6nMAssay Description:The concentration of alanine is 20 mM, and the concentration of IMP is 0.2 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTaste receptor type 1 member 1/3(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM526243(US11185100, TABLE 8.9)
Affinity DataEC50:  3.00E+4nMAssay Description:The concentration of alanine is 20 mM.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50:  4.47E+3nMAssay Description:Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activati...More data for this Ligand-Target Pair
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataKd:  1.21E+3nMAssay Description:Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimet...More data for this Ligand-Target Pair
LigandPNGBDBM50587687(CHEMBL5172157)
Affinity DataKd:  1.21E+3nMAssay Description:Binding affinity to C-terminal domain human STING (139 to 379 residues) expressed in E. coli assessed as dissociation constant by isothermal titratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50587687(CHEMBL5172157)
Affinity DataEC50:  538nMAssay Description:Agonist activity at STING in human L929 cells assessed as IFN-beta RNA level measured after 4 hrs by qRT-PCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine 5'-monophosphoramidase HINT1(Rattus norvegicus)
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM50326433(((2R,3R,4S,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataKd:  6.70E+4nMAssay Description:Binding affinity to mouse HINT1 by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50436163(CHEMBL1231573)
Affinity DataEC50: >4.50E+4nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair