Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 34 hits in this display
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)Ki: >1.00E+5nMAssay Description:Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.More data for this Ligand-Target Pair
BDBM50090857((2R,3R,4S,5R)-2-(4-Amino-5-chloro-pyrrolo[2,3-d]py...)
BDBM50090857((2R,3R,4S,5R)-2-(4-Amino-5-chloro-pyrrolo[2,3-d]py...)
BDBM50090857((2R,3R,4S,5R)-2-(4-Amino-5-chloro-pyrrolo[2,3-d]py...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
IC50: 880nMAssay Description:Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assayMore data for this Ligand-Target Pair
BDBM435532((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
BDBM435532((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
BDBM435532((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human ADK using [3H]-adenosine as substrate after 20 mins by TLC scanner-based analysis relative to controlMore data for this Ligand-Target Pair
BDBM50090845((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...)
BDBM50090851((2R,3R,4S,5R)-2-(4-Amino-5-methyl-pyrrolo[2,3-d]py...)
BDBM50090851((2R,3R,4S,5R)-2-(4-Amino-5-methyl-pyrrolo[2,3-d]py...)
BDBM50090851((2R,3R,4S,5R)-2-(4-Amino-5-methyl-pyrrolo[2,3-d]py...)
BDBM50307455((2S,3S,4R,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...)
BDBM50090851((2R,3R,4S,5R)-2-(4-Amino-5-methyl-pyrrolo[2,3-d]py...)
BDBM50090857((2R,3R,4S,5R)-2-(4-Amino-5-chloro-pyrrolo[2,3-d]py...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
EC50: >1.00E+5nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
BDBM263122(US9708359, 48 | US9708359, 49 | US9708359, 81)
BDBM263122(US9708359, 48 | US9708359, 49 | US9708359, 81)
EC50: >1.00E+5nMAssay Description:Polymerase reactions (10 μL) were conducted for 60 minutes at 37° C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...More data for this Ligand-Target Pair
EC50: 6.10E+4nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
EC50: >1.00E+5nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
BDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
EC50: >1.00E+5nMpH: 7.3 T: 2°CAssay Description:The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...More data for this Ligand-Target Pair
BDBM263122(US9708359, 48 | US9708359, 49 | US9708359, 81)
EC50: >1.00E+5nMAssay Description:Polymerase reactions (10 μL) were conducted for 60 minutes at 37° C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...More data for this Ligand-Target Pair