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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50546335(CHEMBL4755577)

Ki: 2.20nMAssay Description:Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair

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PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527131(CHEMBL4585872)

Ki: 3.30nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527131(CHEMBL4585872)

Ki: 3.60nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527138(CHEMBL4475460)

Ki: 4.60nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527138(CHEMBL4475460)

Ki: 5.90nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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P2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50026203(({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxola...)

Ki: 9nMMore data for this Ligand-Target Pair

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Reactome pathway
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P2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50026203(({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxola...)

Ki: 10.1nMMore data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50527131(CHEMBL4585872)

Ki: 15nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527139(CHEMBL4591580)

Ki: 15nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527139(CHEMBL4591580)

Ki: 16nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50527138(CHEMBL4475460)

Ki: 19nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50019296(CHEMBL3289396)

Ki: 20nMAssay Description:Mixed type inhibition of human NPP1 using pNP-TMP as substrate after 20 mins by Dixon and Cornish-Bowden methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527142(CHEMBL4462911)

Ki: 36nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527142(CHEMBL4462911)

Ki: 39nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 88nMAssay Description:Inhibition of purified recombinant soluble human CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting met...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 88nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 88nMAssay Description:Inhibition of human CD73 using AMP as substrate by Malachite green phosphate reagent-based assayMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 88nMAssay Description:Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair

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PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 88nMAssay Description:Inhibition of CD73 (unknown origin)More data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50527142(CHEMBL4462911)

Ki: 91nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

PDB Reactome pathway
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PDB Reactome pathway
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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50527139(CHEMBL4591580)

Ki: 116nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 167nMAssay Description:Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as subs...More data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 197nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 207nMAssay Description:Inhibition of native CD73 in human MDA-MB-231 cell membrane preparations [3H]AMP as substrate incubated for 25 mins by scintillation counting methodMore data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50527137(CHEMBL4445938)

Ki: 326nMAssay Description:Inhibition of purified recombinant soluble rat CD73 expressed in Sf9 cells [3H]AMP as substrate incubated for 25 mins by scintillation counting metho...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 510nMAssay Description:Inhibition of CD73 in human melanoma 1539 cells using AMP substrate by capillary electrophoresis assayMore data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 870nMAssay Description:Inhibition of rat CD73 expressed in baculovirus infected insect cells using AMP substrate by capillary electrophoresis assayMore data for this Ligand-Target Pair

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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50523534(CHEMBL4468019)

Ki: >1.00E+3nMAssay Description:Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as subs...More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Rattus norvegicus (Rat))
University Of Bonn

Curated by ChEMBL

BDBM50523536(CHEMBL4565565)

Ki: 1.97E+3nMAssay Description:Inhibition of recombinant rat C-terminal His-tagged soluble form of CD73 expressed in baculovirus infected Sf9 insect cells using [2,8-3H]AMP as subs...More data for this Ligand-Target Pair

Reactome pathway
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P2X purinoceptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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P2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50347447(CHEMBL1802096)

Ki: 1.30E+4nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr...More data for this Ligand-Target Pair

UniProtKB/SwissProt
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Glycine--tRNA ligase(Bombyx mori)
Medical College Of Ohio

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

Ki: 6.00E+4nM ΔG°: -24.1kJ/mole IC50: 6.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair

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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50347447(CHEMBL1802096)

Ki: 1.47E+5nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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S-adenosylmethionine synthase isoform type-2(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

Ki: 3.00E+5nMAssay Description:Inhibitory constant against rat kidney Methionine adenosyltransferase IIMore data for this Ligand-Target Pair

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PDB NCI pathway Reactome pathway KEGG
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S-adenosylmethionine synthase isoform type-1/type-2(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

Ki: 3.40E+5nMAssay Description:Inhibitory constant against rat Methionine adenosyltransferase was reportedMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50546335(CHEMBL4755577)

IC50: 4.30nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair

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PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50527138(CHEMBL4475460)

IC50: 5nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 60 ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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P2X purinoceptor 1(RAT)
Universit£

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

IC50: 14nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 50nMAssay Description:Inhibition of human CD73 expressed in CHO cells using AMP as substrate preincubated for 10 mins followed by substrate addition and measured every min...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 60nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in HEK293F cells using [15N]5-AMP as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 187nMAssay Description:Inhibition of human CD73 using AMP as substrate by Malachite green phosphate reagent-based assayMore data for this Ligand-Target Pair

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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50019296(CHEMBL3289396)

IC50: 390nMAssay Description:Mixed type inhibition of human NPP1 using pNP-TMP as substrate after 20 mins by Dixon and Cornish-Bowden methodMore data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 1.10E+3nMAssay Description:Inhibition of recombinant human CD73 using AMP as substrate incubated for 90 mins by malachite green colorimetric assayMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50470563(CHEMBL4283386)

IC50: 2.00E+3nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 2.20E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50470565(CHEMBL4276670)

IC50: 2.20E+3nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair

PDB Reactome pathway
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PDB Reactome pathway
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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 2.50E+3nMAssay Description:Inhibition of recombinant human CD73 using AMP as substrate incubated for 120 mins by CellTiter-Glo assayMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 2.65E+3nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 3.80E+3nMAssay Description:Inhibition of recombinant CD73 (27 to 549 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells assessed as reduction in conv...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 3.97E+3nMAssay Description:Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 3.97E+3nMAssay Description:Inhibition of human CD73More data for this Ligand-Target Pair

PDB Reactome pathway
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5'-nucleotidase(Mus musculus)
The Second Military Medical University

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair

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5'-nucleotidase(Mus musculus)
The Second Military Medical University

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 2.14E+4nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 2.36E+4nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair

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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50347447(CHEMBL1802096)

IC50: 3.30E+4nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Ectonucleoside triphosphate diphosphohydrolase 1(Mus musculus)
Ningxia Medical University

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: >1.00E+5nMAssay Description:Inhibition of mouse CD39More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50470565(CHEMBL4276670)

IC50: 1.12E+5nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

IC50: 1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM50470563(CHEMBL4283386)

IC50: 1.47E+5nMAssay Description:Inhibition of CD73 in human MDA-MB-231 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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PDB Reactome pathway
UniProtKB/SwissProt
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P2Y purinoceptor 1(Homo sapiens (Human))
Bar-Ilan University

Curated by ChEMBL

BDBM50347447(CHEMBL1802096)

EC50: 9.00E+3nMAssay Description:Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescen...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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P2X purinoceptor 4(RAT)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: 3.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) 3 uMMore data for this Ligand-Target Pair

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P2X purinoceptor 1(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: 200nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair

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KEGG
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P2X purinoceptor 6(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: >8.00E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair

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P2X purinoceptor 5(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: >7.00E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair

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P2Y purinoceptor 12(Rattus norvegicus)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: >1.00E+5nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair

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P2Y purinoceptor 1(Meleagris gallopavo)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair

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Reactome pathway
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P2X purinoceptor 2(RAT)
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: 1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair

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5'-nucleotidase(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL

BDBM18136(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)

EC50: 1.63E+4nMAssay Description:Inhibition of CD73 in human NCI-H1568 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and...More data for this Ligand-Target Pair

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P2X purinoceptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: 740nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair

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P2X purinoceptor 7(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL

BDBM50118221(9H-purine derivative | CHEMBL132722 | DIPHOSPHOMET...)

EC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair

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