Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 88 hits in this display
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM81576(AppppA analog, 6 (X=S))
BDBM81580(AppppA analog, 9 (X=S))
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM81577(AppppA analog, 6 (X=O))
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM92538(AMP | [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Ki: 8.00E+4nM ΔG°: -23.4kJ/mole IC50: 8.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM81573(AppppA analog, 4 (X=S))
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Ki: 9.80E+6nMAssay Description:Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibitionMore data for this Ligand-Target Pair
Ki: 1.60E+7nMAssay Description:Inhibitory activity against rat Adenylate kinase M isoenzyme was determined in the presence of ATP, non competitive inhibitionMore data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
IC50: 4.19E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 1.32E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
BDBM50062284(CHEMBL56787 | Thiophosphoric acid 5-(6-amino-purin...)
IC50: 8.80E+4nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
BDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
BDBM50280244(Phosphoric acid mono-[(2R,3R,4S,5R)-5-(6-amino-pur...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
EC50: 1.73E+4nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMore data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
EC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
BDBM526224(US11185100, TABLE 7.10)
BDBM525969(US11185100, TABLE 6.6)
BDBM525969(US11185100, TABLE 6.6)
BDBM525969(US11185100, TABLE 6.6)
BDBM525969(US11185100, TABLE 6.6)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: >1.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: >3.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: >3.00E+4nMAssay Description:HEK293 cells that stably express T1R3 and inducibly express T1R1 were exposed to nucleotide derivatives alone to activate the umami receptor. Activat...More data for this Ligand-Target Pair
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM526098(US11185100, TABLE 7.2)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM526218(US11185100, TABLE 7.9)
BDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: 2.34E+3nMAssay Description:Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reachedMore data for this Ligand-Target Pair
BDBM50062279(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: 1.28E+3nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
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