Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 104 hits in this display
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM92538(AMP | [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
Ki: 8.00E+4nM ΔG°: -23.4kJ/mole IC50: 8.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
IC50: 210nMAssay Description:Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligandMore data for this Ligand-Target Pair
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
IC50: 330nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM50318029(CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM50318029(CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
IC50: 5.76E+3nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
BDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
IC50: 8.40E+3nMAssay Description:Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...More data for this Ligand-Target Pair
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 1.32E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 7.00E+4nMAssay Description:Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
IC50: 1.22E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
BDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
BDBM50280244(Phosphoric acid mono-[(2R,3R,4S,5R)-5-(6-amino-pur...)
EC50: 1.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM,expressed in Xenopus oocytesMore data for this Ligand-Target Pair
EC50: >1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
EC50: >1.00E+5nMAssay Description:The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)More data for this Ligand-Target Pair
EC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
EC50: 1.73E+4nMAssay Description:Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMore data for this Ligand-Target Pair
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
P2Y purinoceptor 1(Homo sapiens (Human))National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50164644(2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM525923(US11185100, TABLE 6.1)
BDBM525923(US11185100, TABLE 6.1)
BDBM526098(US11185100, TABLE 7.2)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM526139(US11185100, TABLE 7.5)
BDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: 6.29E+3nMAssay Description:Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reachedMore data for this Ligand-Target Pair
BDBM50062287(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
EC50: 6.26E+3nMAssay Description:Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranesMore data for this Ligand-Target Pair
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM50192453(AMP(2-) | Adenosine-5-monophosphate | LDHA Inhibit...)
BDBM18137(AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...)
BDBM526148(US11185100, TABLE 7.6)
BDBM61258((5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)...)
EC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
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