Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM50427788(CHEMBL2325197)Copy SMILESCopy InChI

Affinity DataIC50:  360nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM50427772(CHEMBL2325183)Copy SMILESCopy InChI

Affinity DataIC50:  480nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM50427772(CHEMBL2325183)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of G9a (unknown origin) using histone H3 (1 to 25) as substrate after 0.25 hrs by scintillation proximity assay in presence of [3H]-S-aden...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetHistone-lysine N-methyltransferase SUV39H2(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM50427772(CHEMBL2325183)Copy SMILESCopy InChI

Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of SUV39H2 (unknown origin) using histone H3 (1 to 25) as substrate after 0.25 hrs by scintillation proximity assay in presence of [3H]-S-...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistone-lysine N-methyltransferase EHMT1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM50427772(CHEMBL2325183)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of GLP (unknown origin) using histone H3 (1 to 25) as substrate after 0.25 hrs by scintillation proximity assay in presence of [3H]-S-aden...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI