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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Thymidylate synthase
(Mus musculus)
Polish Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50094611
(CHEMBL143376 | Phosphoric acid mono-[5-(5-bromo-2,...)
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Affinity Data
Ki: 460nM
Assay Description:
Time-independent inhibition of thymidylate synthase from FdUrd-resistant L1210 cells
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Thymidylate synthase
(Lactobacillus casei)
TBA
Curated by
ChEMBL
Ligand
BDBM50010238
(CHEMBL1160593)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...
More data for this Ligand-Target Pair
Target Info
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MMDB
KEGG
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Target
Thymidylate synthase
(Lactobacillus casei)
TBA
Curated by
ChEMBL
Ligand
BDBM50010238
(CHEMBL1160593)
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Affinity Data
Ki: 1.40E+3nM
Assay Description:
Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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DrugBank
GoogleScholar
Ligand Info
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Target
Thymidylate synthase
(Mus musculus)
Polish Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50094611
(CHEMBL143376 | Phosphoric acid mono-[5-(5-bromo-2,...)
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Affinity Data
Ki: 1.50E+3nM
Assay Description:
Time-independent inhibition of thymidylate synthase from parenteral L1210 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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Article
PubMed
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Target
Thymidylate synthase
(Lactobacillus casei)
TBA
Curated by
ChEMBL
Ligand
BDBM50186267
(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
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Affinity Data
Ki: 2.26E+3nM
Assay Description:
Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
ChEBI
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Target
Thymidylate synthase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50028108
(2'-Deoxyuridinemonophosphate | DEOXYURIDINE MONOPH...)
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Affinity Data
Ki: 3.00E+3nM
Assay Description:
Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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antibodypedia
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PubMed
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Target
Thymidylate synthase
(Mus musculus)
Polish Academy Of Sciences
Curated by
ChEMBL
Ligand
BDBM50186267
(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
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Affinity Data
Ki: 6.50E+3nM
Assay Description:
Competitive inhibition of purified mouse Ehrlich ascites tumor cell thymidylate synthetase using 5-[3H]-2'-deoxyuridine 5'-phosphate as substrate aft...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
ChEBI
CHEMBL
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KEGG
MMDB
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Article
PubMed
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Target
Thymidylate synthase
(Bos taurus)
TBA
Curated by
ChEMBL
Ligand
BDBM50186267
(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
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Affinity Data
Ki: 8.00E+3nM
Assay Description:
Competitive inhibition of purified calf thymus thymidylate synthetase using 5-[3H]-2'-deoxyuridine 5'-phosphate as substrate after 7 mins by double r...
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
ChEBI
CHEMBL
DrugBank
KEGG
MMDB
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PC sid
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Target
Deoxyuridine triphosphatase, putative
(Trypanosoma cruzi)
Cardiff University
Curated by
ChEMBL
Ligand
BDBM50186267
(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
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Affinity Data
Ki: 1.84E+4nM
Assay Description:
Inhibition of Trypanosoma cruzi dUTPase at 1 mM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
ChEBI
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MMDB
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Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase
(Plasmodium falciparum)
Cardiff University
Curated by
ChEMBL
Ligand
BDBM50173549
(CHEMBL3143776 | Phosphoric acid 5-(2,4-dioxo-3,4-d...)
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Affinity Data
Ki: 3.16E+5nM
Assay Description:
Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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GoogleScholar
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CHEMBL
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Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
(Homo sapiens (Human))
Cardiff University
Curated by
ChEMBL
Ligand
BDBM50173549
(CHEMBL3143776 | Phosphoric acid 5-(2,4-dioxo-3,4-d...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
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In Depth
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Article
PubMed
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Target
Putative deoxyuridine triphosphatase
(Leishmania major)
Cardiff University
Curated by
ChEMBL
Ligand
BDBM50173549
(CHEMBL3143776 | Phosphoric acid 5-(2,4-dioxo-3,4-d...)
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Affinity Data
Ki: >1.00E+6nM
Assay Description:
Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
P2Y purinoceptor 2
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM50199184
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
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Affinity Data
EC50: >1.00E+3nM
Assay Description:
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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ChEBI
CHEMBL
MMDB
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In Depth
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Article
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Target
P2Y purinoceptor 6
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM50199184
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
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Affinity Data
EC50: >1.00E+3nM
Assay Description:
Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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ChEBI
CHEMBL
MMDB
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PC sid
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In Depth
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Article
PubMed
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Target
P2Y purinoceptor 4
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM50199184
(5-BROMO-URIDINE-5'-MONOPHOSPHATE | 5-bromo-1-beta-...)
Copy SMILES
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Affinity Data
EC50: >1.00E+5nM
Assay Description:
Agonist activity at human P2Y4 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MMDB
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI