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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
29
hits in this display
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169911
(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169903
(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(isopropyl-met...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162105
(3-Cyclohexyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-2-p-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169920
(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methyl-pi...)
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Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162104
(2-(4-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibitory concentration against NS5B polymerase of Hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162095
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-p-tolyl-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169932
(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(dimethylcarba...)
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Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162108
(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 26nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162108
(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 26nM
Assay Description:
Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169933
(3-Cyclohexyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 39nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162093
(2-(3-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169898
(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 41nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162102
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 59nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162102
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 59nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162102
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 59nM
Assay Description:
Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169946
(3-Cyclohexyl-1-[(isopropyl-methyl-carbamoyl)-methy...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 62nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169924
(3-Cyclohexyl-1-[(cyclopropylmethyl-carbamoyl)-meth...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 63nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169928
(3-Cyclopentyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 68nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169901
(3-Cyclohexyl-1-[(dimethylcarbamoylmethyl-methyl-ca...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 98nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162100
(3-Cyclohexyl-1-(2-morpholin-4-yl-ethyl)-2-phenyl-1...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 111nM
Assay Description:
Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169923
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-pyridin-4...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 134nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50169902
(3-Cyclohexyl-2-(4-dimethylaminomethyl-phenyl)-1-di...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 920nM
Assay Description:
Inhibitory activity against by hepatitis C virus NS5B polymerase
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162102
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-phenyl-1H...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.5nM
Assay Description:
Effective concentration to inhibit the activity of RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162095
(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-p-tolyl-1...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 0.5nM
Assay Description:
Effective concentration to inhibit the activity of RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162104
(2-(4-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 0.900nM
Assay Description:
Effective concentration for inhibitory activity against NS5B polymerase of Hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162100
(3-Cyclohexyl-1-(2-morpholin-4-yl-ethyl)-2-phenyl-1...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 4.60nM
Assay Description:
Effective concentration for inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162108
(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 0.800nM
Assay Description:
Effective concentration to inhibit the activity of RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162105
(3-Cyclohexyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-2-p-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 300nM
Assay Description:
Effective concentration to inhibit the activity of RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
RNA-directed RNA polymerase
(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by
ChEMBL
Ligand
BDBM50162093
(2-(3-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 4.5nM
Assay Description:
Effective concentration to inhibit the activity of RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI