Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 147 hits in this display
BDBM20876((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-methoxyoxane-...)
BDBM50454778(CHEBI:320055 | CHEMBL132186)Ki: 6.80E+5nMAssay Description:Inhibition of Escherichia coli Heptosyltransferase I assessed as reduction in ADP release using ODLA and ADP-heptose substrates in presence of phosph...More data for this Ligand-Target Pair
BDBM20876((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-methoxyoxane-...)
BDBM50057750((2S,3R,4S,5S,6R)-6-(3,4,5-Trihydroxy-6-hydroxymeth...)
BDBM50147927((R)-2-Hydroxymethyl-6-methoxy-tetrahydro-pyran-3,4...)
BDBM50454778(CHEBI:320055 | CHEMBL132186)
BDBM455844(US10722597, Compound HP-beta-CD)
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 7.49nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 8.65nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 15.9nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 20.3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 55.7nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 110nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM11(beta-cyclodextrin | betadex)
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 567nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 927nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 1.38E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM50179253((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
BDBM455844(US10722597, Compound HP-beta-CD)
IC50: 1.82E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)IC50: 1.90E+3nMAssay Description:Antagonist activity at Escherichia coli recombinant C-terminal 6His-tagged FimH-CRD with a C-terminal thrombin cleavage site expressed in Escherichia...More data for this Ligand-Target Pair
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
IC50: 3.70E+4nMAssay Description:Competitive inhibition of N-(fluorescein-5-yl)-N'-(alpha-L-fucopyranosyl ethylen)-thiocarbamide binding to Pseudomonas aeruginosa PA14 LecB after 8 t...More data for this Ligand-Target Pair
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
IC50: 4.68E+4nMAssay Description:Competitive binding affinity to recombinant Pseudomonas aeruginosa PA14 LecB expressed in Escherichia coli BL21(DE3) incubated for 4 to 8 hrs by fluo...More data for this Ligand-Target Pair
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
IC50: >1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase activity assessed as residual enzyme activity by poly(rA)n.oligo(dT)12-18-directed incorporation of [3H]dTTP...More data for this Ligand-Target Pair
BDBM50478441(CHEBI:15754 | CHEMBL446492)IC50: >1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase activity assessed as residual enzyme activity by poly(rA)n.oligo(dT)12-18-directed incorporation of [3H]dTTP...More data for this Ligand-Target Pair
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
IC50: 1.04E+5nMAssay Description:Competitive binding affinity to recombinant Pseudomonas aeruginosa PAO1 LecB expressed in Escherichia coli BL21(DE3) incubated for 4 to 8 hrs by fluo...More data for this Ligand-Target Pair
Lectin A(Photorhabdus laumondii subsp. laumondii (strain DS...)Indian Institute Of Technology Bombay
Curated by ChEMBL
BDBM50598573(CHEBI:16634 | RAFFINOSE | Raffinose)IC50: 1.10E+5nMAssay Description:Inhibition of Photorhabdus luminescens LecA expressed in Escherichia coli BL21(DE3) cells by fluorescence based analysisMore data for this Ligand-Target Pair
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
BDBM103981(LecB Inhibitor Compound 1)
BDBM50272147((2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6R)-6-(6-((2S,3S,...)
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
BDBM50377984(Cephulac Syrup | Cholac | Chronulac | Constilac | ...)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50370453(LACTOSE | Lactose, anhydrous)
IC50: 1.00E+6nMAssay Description:Inhibition of galectin-3 in C57BL/6 mouse jejunum using SK-5100 as substrate incubated for 30 mins by VAA staining based microscopic analysisMore data for this Ligand-Target Pair
BDBM50240023(CHEBI:75323 | Importal | Lactitol)
Galectin(Gallus gallus)Ludwig-Maximilians-University Munich
Curated by ChEMBL
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
BDBM50304487((2R,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
BDBM50304488((2S,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)IC50: 2.83E+6nMAssay Description:Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...More data for this Ligand-Target Pair
BDBM50370453(LACTOSE | Lactose, anhydrous)
Galectin(Gallus gallus)Ludwig-Maximilians-University Munich
Curated by ChEMBL
BDBM50370453(LACTOSE | Lactose, anhydrous)
IC50: 4.50E+6nMAssay Description:Inhibition of binding of biotinylated truncated chicken galectin-3 to surface immobilized asialofetuin by solid phase assayMore data for this Ligand-Target Pair
BDBM50572952(CHEBI:17716 | CHEMBL1159651)
BDBM120768(US8703720, Reference Compound 1)
BDBM120768(US8703720, Reference Compound 1)
Kd: 4.40E+6nMAssay Description:Compounds 7, 15-19, and 22 were evaluated for their efficiency in inhibiting galectin-1 and galectin-3 in a known fluorescence polarization-based ass...More data for this Ligand-Target Pair
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Kd: 5.20E+4nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
BDBM50034081(CHEBI:55507 | CHEMBL467773)
BDBM50179253((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
BDBM50179253((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
BDBM50179253((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50244377(CHEMBL502337 | methyl beta-D-talopyranoside)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50244377(CHEMBL502337 | methyl beta-D-talopyranoside)
BDBM50244377(CHEMBL502337 | methyl beta-D-talopyranoside)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM11(beta-cyclodextrin | betadex)
BDBM11(beta-cyclodextrin | betadex)
BDBM50370453(LACTOSE | Lactose, anhydrous)
Kd: 17nMAssay Description:Binding affinity to Escherichia coli J96 wild type FimH lectin domain expressed in Escherichia coli C43 (DE3) by direct ITC analysisMore data for this Ligand-Target Pair
Kd: 19nMAssay Description:Binding affinity to Escherichia coli J96 wild type FimH lectin domain expressed in Escherichia coli C43 (DE3) by reverse ITC analysisMore data for this Ligand-Target Pair
FimH(Escherichia coli)Lunam Universit£
Curated by ChEMBL
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50304487((2R,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
BDBM50304488((2S,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
Kd: 2.76E+6nMAssay Description:Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...More data for this Ligand-Target Pair
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 1.00E+7nMAssay Description:Binding affinity at recombinant human C-terminal Galectin 4 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 4.10E+6nMAssay Description:Binding affinity at recombinant human Galectin 3 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: >1.00E+7nMAssay Description:Binding affinity at recombinant human Galectin 1 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 6.60E+6nMAssay Description:Binding affinity at recombinant human N-terminal Galectin 4 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Kd: 1.10E+7nMAssay Description:Binding affinity at recombinant human C-terminal Galectin 4 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 4.80E+6nMAssay Description:Binding affinity at recombinant human Galectin 7 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 6.30E+6nMAssay Description:Binding affinity at recombinant human N-terminal Galectin 8 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 3.30E+6nMAssay Description:Binding affinity at recombinant human N-terminal Galectin 9 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 8.60E+6nMAssay Description:Binding affinity at recombinant human C-terminal Galectin 9 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 1.30E+7nMAssay Description:Binding affinity at recombinant human Galectin 2 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Kd: 1.00E+7nMAssay Description:Binding affinity at recombinant human Galectin 1 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Kd: 1.00E+7nMAssay Description:Binding affinity at recombinant human Galectin 2 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: >3.00E+7nMAssay Description:Binding affinity at recombinant human C-terminal Galectin 8 expressed in Escherichia coli BL21 incubated for 5 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
BDBM50370453(LACTOSE | Lactose, anhydrous)
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 1.00E+6nMAssay Description:Binding affinity to human galectin-4 C terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 6.30E+6nMAssay Description:Binding affinity to human galectin-8 N terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: >3.00E+7nMAssay Description:Binding affinity to human galectin-8 C terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 3.30E+6nMAssay Description:Binding affinity to human galectin-9 N terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 8.60E+6nMAssay Description:Binding affinity to human galectin-9 C terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: >1.00E+7nMAssay Description:Binding affinity to human galectin-1 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 1.30E+7nMAssay Description:Binding affinity to human galectin-2 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 4.40E+6nMAssay Description:Binding affinity to human galectin-3 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 6.60E+6nMAssay Description:Binding affinity to human galectin-4 N terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 6.30E+6nMAssay Description:Binding affinity to human galactin-8 N terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50370453(LACTOSE | Lactose, anhydrous)
Kd: 9.10E+4nMAssay Description:Binding affinity to human galactin-8 N terminal domain assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50243888(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Kd: 4.40E+6nMAssay Description:Binding affinity to human galactin-3 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50370453(LACTOSE | Lactose, anhydrous)
Kd: 2.31E+5nMAssay Description:Binding affinity to human galactin-3 assessed as dissociation constant by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
BDBM50572952(CHEBI:17716 | CHEMBL1159651)
BDBM50598573(CHEBI:16634 | RAFFINOSE | Raffinose)
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
Kd: 430nMAssay Description:Binding affinity to recombinant Pseudomonas aeruginosa LecA expressed in Escherichia coli BL21 (DE3) expression system assessed as dissociation const...More data for this Ligand-Target Pair
BDBM50166886(CHEMBL195368 | methyl alpha-D-mannoside)
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