Home
About
Info
Download
WebServices
Contact
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 229nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Hrh3 protein
(RAT)
Schering-Plough Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
PubMed
Copy BDB DOI
Target
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human))
Probiodrug
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+5nM ΔG°: -23.2kJ/mole
pH: 8.0 T: 2°C
Assay Description:
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Glutaminyl-peptide cyclotransferase
(Mus musculus (mouse))
Probiodrug
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.60E+5nM ΔG°: -22.0kJ/mole
pH: 8.0 T: 2°C
Assay Description:
QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.75E+5nM
Assay Description:
Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrulline
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
The Procter & Gamble
US Patent
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+4nM
Assay Description:
Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
US Patent
Copy BDB DOI
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Wake Forest University Winston-Salem
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.00E+4nM
Assay Description:
Inhibition of purified mouse inducible nitric oxide synthase catalyzed [14C]-L-citrulline production at a compound concentration of 1 mM in presence ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human))
Probiodrug
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.52E+5nM
Assay Description:
Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analys...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
PubMed
Copy BDB DOI
Target
Thromboxane-A synthase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.70E+5nM
Assay Description:
Inhibitory activity against thromboxane A2 synthetase
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostacyclin synthase
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.00E+6nM
Assay Description:
Inhibition of porcine aorta prostacyclin PGI-2 synthase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1/2
(Ovis aries (Sheep))
TBA
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+7nM
Assay Description:
Inhibition of ram seminal vesicle Cyclooxygenase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Peptidyl-prolyl cis-trans isomerase FKBP5
(Homo sapiens (Human))
Boehringer Ingelheim Pharma
Curated by
ChEMBL
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 4.40E+6nM
Assay Description:
Binding affinity to 15N-labeled FKBP51 (1 to 140 residues) (unknown origin) expressed in Escherichia coli OD2N by two-dimensional 1H/15N HSQC NMR spe...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Dehaloperoxidase B
(Amphitrite ornata)
North Carolina State University
Ligand
BDBM7882
(1H-imidazole | CHEMBL540 | Imidazole (Im) | US9138...)
Copy SMILES
Copy InChI
Affinity Data
Kd: 5.20E+4nM
pH: 7.0
Assay Description:
Samples for solution resonance Raman spectroscopic studies were prepared withfinal concentrations of 75 μM WT DHP B and 3.75 mM azole in 100 mM ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
Purchase
ChEBI
CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
PubMed
Copy BDB DOI