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Found 503 Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-2'
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  1nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrateMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  1nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  330nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50550643(CHEMBL4749207)
Affinity DataKi:  487nMAssay Description:Binding affinity to human 20S constitutive proteasome beta 2 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLR-AMC as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410909(CHEMBL207591 | PSI)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599554(CHEMBL5172870)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599553(CHEMBL5198329)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599556(CHEMBL5182479)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50453651(CHEMBL4205881)
Affinity DataKi:  4.38E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599554(CHEMBL5172870)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  5.52E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Z-Leu-Leu-Leu-al as substrateMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  5.52E+3nMAssay Description:Inhibition of 20s constitutive proteasome beta2 trypsin-like activity in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by f...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50453650(CHEMBL4213821)
Affinity DataKi:  5.57E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50453683(CHEMBL4208777)
Affinity DataKi:  6.71E+3nMAssay Description:Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by fluorescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599552(CHEMBL5195299)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599555(CHEMBL5192242)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599553(CHEMBL5198329)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599551(CHEMBL5207762)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599551(CHEMBL5207762)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of 20S constitutive proteosome beta2c subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50453651(CHEMBL4205881)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of 20s constitutive proteasome beta2 trypsin-like activity in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate after 10 mins by f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599556(CHEMBL5182479)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataKi:  2.21E+4nMAssay Description:Competitive inhibition of trypsin-like activity of human 20S proteasome using Boc-Leu-Arg-Arg-AMC as substrate measured for 10 mins by fluorescence a...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599555(CHEMBL5192242)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50599557(CHEMBL5196430)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibition of 20S immuno proteosome beta2i subunit (unknown origin) assessed as substrate hydrolysis using Boc-Leu-Arg-Arg-AMC as fluorogenic substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410900(CHEMBL207425)
Affinity DataKi:  5.10E+4nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50069984((R)-1-((S)-2-((S)-2-(benzyloxycarbonyl)-4-methylpe...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410898(CHEMBL205757)
Affinity DataKi:  2.90E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410903(CHEMBL207598)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410899(CHEMBL383674)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410901(CHEMBL206413)
Affinity DataKi: >4.50E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410902(CHEMBL205687)
Affinity DataKi: >4.50E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410904(CHEMBL377532)
Affinity DataKi: >9.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50410896(CHEMBL383122)
Affinity DataKi: >9.00E+5nMAssay Description:Inhibition of trypsin-like proteasome activity of human 20S proteasomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517643(CHEMBL4451682)
Affinity DataIC50:  5nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  6nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517607(CHEMBL4590398)
Affinity DataIC50:  7nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517617(CHEMBL4458756)
Affinity DataIC50:  8nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517607(CHEMBL4590398)
Affinity DataIC50:  8nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517643(CHEMBL4451682)
Affinity DataIC50:  10nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517609(CHEMBL4440581)
Affinity DataIC50:  11nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517647(CHEMBL4463326)
Affinity DataIC50:  11nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50: >11nMAssay Description:Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50426994(CHEMBL2326533)
Affinity DataIC50:  11nMAssay Description:Inhibition of human 20S constitutive proteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50430961(CHEMBL2337844)
Affinity DataIC50:  12nMAssay Description:Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50517633(CHEMBL4471150)
Affinity DataIC50:  13nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50426994(CHEMBL2326533)
Affinity DataIC50:  13nMAssay Description:Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50307481((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50307481((S)-2-azido-N-((S)-1-((S)-1-((S)-4-methyl-1-((R)-2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based compet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50430968(CHEMBL2337847)
Affinity DataIC50:  14nMAssay Description:Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-2(Homo sapiens (Human))
University Of Messina

Curated by ChEMBL
LigandPNGBDBM50430969(CHEMBL2337846)
Affinity DataIC50:  15nMAssay Description:Inhibition of trypsin-like activity of human constitutive 20s proteasome beta-2 subunit using Boc-LRR-AMC as substrate assessed as remaining activity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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