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Found 46 Enz. Inhib. hit(s) with Target = 'Acid-sensing ion channel 1'
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute Of Physiology Of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Affinity DataIC50:  27nMpH: 6.7Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute Of Physiology Of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50348098(CHEMBL1800430)
Affinity DataIC50:  224nMAssay Description:Inhibition of ASIC1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50157090(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute Of Physiology Of Nas Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Affinity DataIC50:  7.34E+3nMpH: 5.0Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510035(CHEMBL4528810)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510055(CHEMBL4440787)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510050(CHEMBL4463485)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510056(CHEMBL4450681)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510052(CHEMBL4446500)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510049(CHEMBL4590631)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510051(CHEMBL4527919)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510053(CHEMBL4591499)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510054(CHEMBL4445209)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510036(CHEMBL4555958)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510037(CHEMBL4463769)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510048(CHEMBL4442568)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510047(CHEMBL4517411)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510046(CHEMBL4440380)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510045(CHEMBL4587871)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510044(CHEMBL4462808)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510043(CHEMBL4524195)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1/2(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510034(CHEMBL4593063)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510034(CHEMBL4593063)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510057(CHEMBL4538655)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510038(CHEMBL4518161)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510039(CHEMBL4456021)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510040(CHEMBL4469611)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510041(CHEMBL4476781)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510042(CHEMBL4593172)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Affinity DataIC50:  3.02E+4nMAssay Description:Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Affinity DataIC50:  5.69E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250133(Butibufen)
Affinity DataIC50:  1.82E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169044((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
Affinity DataIC50:  2.88E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50:  3.47E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250130(CHEMBL4083814)
Affinity DataIC50:  4.17E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  5.13E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  5.13E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250132(CHEMBL4080879)
Affinity DataIC50:  9.55E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50295285((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...)
Affinity DataIC50:  1.02E+6nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250131(CHEMBL190275)
Affinity DataIC50: <1.00E+7nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed