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Found 390 Enz. Inhib. hit(s) with Target = 'Adenylate cyclase type 1'
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144001(3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...)
Affinity DataKi:  14nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144020(3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...)
Affinity DataKi:  17nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144015(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...)
Affinity DataKi:  20nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222264(CHEMBL552736)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144008(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Affinity DataKi:  29nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222266(CHEMBL369006)
Affinity DataKi:  33nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144002(3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...)
Affinity DataKi:  33nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144008(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)
Affinity DataKi:  69nMAssay Description:In vitro inhibitory activity against glucagon induced monkey adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144003(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-trifluoromethox...)
Affinity DataKi:  110nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  118nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144016(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Affinity DataKi:  144nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222265(CHEMBL541633)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144009(3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(4-trifluorome...)
Affinity DataKi:  254nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144004(3-{4-[2-(Biphenyl-4-ylcarbamoyl)-2-(4-tert-butyl-p...)
Affinity DataKi:  300nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144012(4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-phenyl)-...)
Affinity DataKi:  317nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144006(3-{4-[2-(4-tert-Butyl-phenyl)-2-(quinolin-3-ylcarb...)
Affinity DataKi:  610nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144005(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-hydroxymethyl-p...)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144010(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144011(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-ethyl-phenylcar...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144013(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-trifluoromethox...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144018(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-pyrazol-1-yl-ph...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144000(3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-piperidin-1-yl-...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144014(3-{4-[2-(4-tert-Butyl-phenyl)-3-(4-ethyl-piperazin...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144017(3-{4-[2-(4-tert-Butyl-phenyl)-3-oxo-3-(4-p-tolyl-p...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144007(3-{4-[2-(4-tert-Butyl-phenyl)-2-(3-ethyl-phenylcar...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50144019(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro inhibitory activity against glucagon induced human adenylate cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50005379(8-Adamantan-1-yl-1,3-dipropyl-3,7-dihydro-purine-2...)
Affinity DataKi: >5.00E+3nMAssay Description:KB for inhibition of adenylate cyclase stimulation in human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1/2/3/4/5/6/7/8/9(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50227472(CHEMBL2372272)
Affinity DataKi:  4.40E+6nMAssay Description:In vitro antagonist activity of the compound was measured by inhibition of vasopressin-stimulated adenylate cyclase in renal medullary preparation in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607682(CHEMBL5220685)
Affinity DataIC50:  1nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of dopamine-sensitive rat brain adenylyl cyclase activity assessed as cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607676(CHEMBL5218698)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607678(CHEMBL5218878)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607681(CHEMBL5218552)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607679(CHEMBL5218615)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607682(CHEMBL5220685)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607686(CHEMBL5219830)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607683(CHEMBL5219579)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607676(CHEMBL5218698)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607680(CHEMBL5218702)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50497055(CHEMBL3244459)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of dopamine-sensitive rat brain adenylyl cyclase activity assessed as cAMP levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607685(CHEMBL5220647)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607684(CHEMBL5219443)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607678(CHEMBL5218878)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607686(CHEMBL5219830)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607673(CHEMBL5220895)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607674(CHEMBL5220347)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607685(CHEMBL5220647)
Affinity DataIC50:  11nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607672(CHEMBL5220723)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Rattus norvegicus)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607679(CHEMBL5218615)
Affinity DataIC50:  15nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenylate cyclase type 10(Homo sapiens (Human))
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607675(CHEMBL5219922)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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