Compile Data Set for Download or QSAR
maximum 50k data
Found 333 Enz. Inhib. hit(s) with Target = 'DNA-(apurinic or apyrimidinic site) endonuclease'
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26621(4-[dihydroxy(oxo)--stibanyl]-2-nitrobenzoic acid |...)
Affinity DataKi:  19nM ΔG°:  -43.6kJ/mole IC50:  4nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26622(Compound 13793 | ethyl 4-{4-[dihydroxy(oxo)--stiba...)
Affinity DataKi:  36nM ΔG°:  -42.1kJ/mole IC50:  17nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92732(NSC332395, 4)
Affinity DataKi:  120nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318446(NSC332395 | US9624235, Compound 4)
Affinity DataKi:  120nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318443(NSC332398 | US9624235, Compound 1)
Affinity DataKi:  180nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92729(NSC332398, 1)
Affinity DataKi:  180nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92731(NSC332389, 3)
Affinity DataKi:  190nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318445(NSC332389 | US9624235, Compound 3)
Affinity DataKi:  190nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318444(NSC332384 | US9624235, Compound 2)
Affinity DataKi:  220nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92730(NSC332384, 2)
Affinity DataKi:  220nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318448(NSC332397 | US9624235, Compound 6)
Affinity DataKi:  640nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92733(NSC332396, 5)
Affinity DataKi:  680nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318447(NSC332396 | US9624235, Compound 5)
Affinity DataKi:  680nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318454(NSC614430 | US9624235, Compound 13)
Affinity DataKi:  4.90E+3nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92740(NSC614430, 13)
Affinity DataKi:  4.90E+3nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318452(NSC131534 | US9624235, Compound 11)
Affinity DataKi:  6.70E+3nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92738(NSC131534, 11)
Affinity DataKi:  6.70E+3nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318449(NSC300598 | US9624235, Compound 7)
Affinity DataKi:  1.09E+4nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92735(NSC300598, 7)
Affinity DataKi:  1.09E+4nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92736(NSC89640, 9)
Affinity DataKi:  1.30E+4nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318450(NSC89640 | US9624235, Compound 9)
Affinity DataKi:  1.30E+4nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318451(NSC107215 | US9624235, Compound 10)
Affinity DataKi:  1.70E+4nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92737(NSC107215, 10)
Affinity DataKi:  1.70E+4nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92739(NSC375491, 12 | US9624235, Compound 12)
Affinity DataKi:  3.20E+4nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92739(NSC375491, 12 | US9624235, Compound 12)
Affinity DataKi:  3.20E+4nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM92741(NSC402686, 14)
Affinity DataKi:  3.70E+4nMAssay Description:A fluorescenc-based molecular beacon assay to measure APE-1 protein activity and inhibition was performed as described.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM318455(NSC402686 | US9624235, Compound 14)
Affinity DataKi:  3.70E+4nMAssay Description:The initial screen was designed to look at the effect of potential inhibitors on APE1 repair kinetics. The approach can be used as a high throughput ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50453751(CHEMBL4210534)
Affinity DataIC50:  55nMAssay Description:Inhibition of human APE1 assessed as reduction in abasic sites DNA cleavage using 6-FAM/TAMRA labelled 17-Tphi as substrate by fluorescence-based ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of APE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM60996(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50453744(CHEMBL4205402)
Affinity DataIC50:  57nMAssay Description:Inhibition of human APE1 assessed as reduction in abasic sites DNA cleavage using 6-FAM/TAMRA labelled 17-Tphi as substrate by fluorescence-based ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50066721(1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibition of full length human APE1 expressed in Escherichia coli BL21/DE3 assessed as inhibition of incision of depurinated supercoiled pUC18 plasm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50436204(CHEMBL109037)
Affinity DataIC50:  110nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50436204(CHEMBL109037)
Affinity DataIC50:  110nMAssay Description:Inhibition of human APE1 after 25 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26613((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50453740(CHEMBL4217125)
Affinity DataIC50:  200nMAssay Description:Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM203861((5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophe...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant human APE1 using double-stranded DNA as substrate preincubated for 15 mins followed by substrate addition measured at 1 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM203861((5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophe...)
Affinity DataIC50:  250nMpH: 7.5Assay Description:In this assay, the complementary single-stranded oligonucleotides at 100 μm were mixed at a 1:1 ratio and annealed in assay buffer (50 mm Tris pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50029028((cibacron blue,para isomer)1-Amino-4-{4-[4-chloro-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM4293((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM26618(Compound 15596 | N-{4-[dihydroxy(oxo)--stibanyl]ph...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM114257(3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-q...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human APE1 using a 5'-TAMRA labelled THF abasic site double-stranded oligodeoxynucleotide as substrate in presence of Mg2+ by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50579(3,6,7-trimethoxyphenanthrene-2,5-diol | MLS0008635...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human APE1 using a 5'-TAMRA labelled THF abasic site double-stranded oligodeoxynucleotide as substrate in presence of Mg2+ by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50:  500nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50453747(CHEMBL4211672)
Affinity DataIC50:  800nMAssay Description:Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50453750(CHEMBL4203747)
Affinity DataIC50:  900nMAssay Description:Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavageMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50241313((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM114652(CHEMBL1706858 | MLS003178551 | N-[3-(1,3-benzothia...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant APE1 using [35P]-5'-AP-DNA as substrate incubated for 15 mins prior to substrate addition measured after 5 mins by PAGE ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
The Johns Hopkins University

LigandPNGBDBM50303973((E)-N-(2-Hydroxyethyl)-3-(3-chloro-1,4-dioxonaphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 333 total ) | Next | Last >>
Jump to: