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Found 233 Enz. Inhib. hit(s) with Target = 'NEDD8'
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601510(CHEMBL5170838)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601479(CHEMBL5182746)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601508(CHEMBL5206652)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  0.955nMAssay Description:Inhibition of recombinant human APPBP1/UBA3 expressed in Escherichia coli assessed as Ub/Ubl thioester transferMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601511(CHEMBL5181979)
Affinity DataIC50:  1nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601501(CHEMBL5173723)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601494(CHEMBL5192493)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320991(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321049(US10174040, Example 132 | [(2R,3S,4R,5R)-5-[4-Amin...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320974(4-Amino-5-[2-[2,6-difluoro-4-(2-oxopyrrolidin-1-yl...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320969(4-Amino-5-[2-(4-amino-2,6-difluoro-phenyl)ethynyl]...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320968(4-[4-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320967(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320956(4-Amino-5-[2-(2,6-difluorophenyl)ethynyl]-7-[(2R,3...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321007(4-[4-[2-[4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320979(4-Amino-5-[2-[2,6-difluoro-4-(3-hydroxyazetidin-1-...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320980(4-Amino-5-[2-[2,6-difluoro-4-[(3R)-3-hydroxy-1-pip...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321008(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320994(Methyl 4-[2-[4-amino-7-[(2R,3R,4S,5R)-3,4-dihydrox...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321048(US10174040, Example 131 | [(2R,3S,4R,5R)-5-[4-amin...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321046(4-Amino-7-[(1R,4R,5S)-4,5-dihydroxy-3-[(sulfamoyla...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320981(1-[4-[2-[4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321034(4-Amino-7-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(sulfamo...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321033(4-Amino-7-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(sulfamo...)
Affinity DataIC50: <3nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321010(2-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(s...)
Affinity DataIC50:  3.20nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321045(4-Amino-5-[2-(2,6-difluorophenyl)ethynyl]-7-[(1R,4...)
Affinity DataIC50:  3.30nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320988(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  3.5nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320978(4-Amino-5-[2-[2,6-difluoro-4-(3-hydroxy-1-piperidy...)
Affinity DataIC50:  3.5nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601496(CHEMBL5197178)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320997(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  3.80nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321035(4-Amino-5-[2-[2,6-difluoro-4-[(3R)-3-fluoropyrroli...)
Affinity DataIC50:  4nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  4nMAssay Description:Inhibition of NAE1/UBA3 in human HCT-116 cells assessed as reduction in Ubc12-NEDD8 level incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321047(4-Amino-7-[(1R,4R,5S)-4,5-dihydroxy-3-[(sulfamoyla...)
Affinity DataIC50:  4nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  4nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320976(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  4.10nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50601503(CHEMBL5209054)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321039(4-Amino-5-[2-[2,6-difluoro-4-(4-hydroxy-1-piperidy...)
Affinity DataIC50:  4.20nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320982(4-Amino-5-[2-[2,6-difluoro-4-(4-oxo-1-piperidyl)ph...)
Affinity DataIC50:  4.30nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321037(4-Amino-7-[(1R,2S,3R,4R)-2,3-dihydroxy-4-[(sulfamo...)
Affinity DataIC50:  4.30nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321040(4-Amino-5-[2-[2,6-difluoro-4-[(3R)-3-hydroxypyrrol...)
Affinity DataIC50:  4.30nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321006(4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamo...)
Affinity DataIC50:  4.40nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320990(4-Amino-5-[2-(2,6-difluoro-4-hydroxy-phenyl)ethyny...)
Affinity DataIC50:  4.5nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8(Homo sapiens)
Temple University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of NEDD8 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM320970(4-Amino-5-[2-[2,6-difluoro-4-(methylamino)phenyl]e...)
Affinity DataIC50:  4.80nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321009(4-Amino-5-[2-(5-benzyloxypyrimidin-2-yl)ethynyl]-7...)
Affinity DataIC50:  5.10nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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