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Found 114 Enz. Inhib. hit(s) with Target = 'Aurora kinase B/Inner centromere protein'
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM209861(5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methyl...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of Aurora B/INCENP (unknown origin) assessed as affinity constant pre-incubated for 1 hr followed by FL-PKAtide substrate and ATP additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of human Aurora B/INCENP pre-incubated for 30 mins before 5-FAM-PKAtide substrate addition and measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465482(CHEMBL4288628)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465481(CHEMBL4291472)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465478(CHEMBL4286130)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50341520(3-(4-(Piperidin-1-yl)benzoylamino)-5-(pyridin-4-yl...)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465486(CHEMBL4282263)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465490(CHEMBL4280041)
Affinity DataKi:  1.29E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465485(CHEMBL4292538)
Affinity DataKi:  1.51E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465488(CHEMBL4295011)
Affinity DataKi:  1.87E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50226223(CHEMBL302219)
Affinity DataKi:  2.57E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465492(CHEMBL4292942)
Affinity DataKi:  3.29E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50341532(3-Benzoylamino-5-(pyridin-4-yl)-(1H)-pyridin-2-one...)
Affinity DataKi:  4.10E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465484(CHEMBL4280308)
Affinity DataKi:  4.17E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM34651(Amrinon | Amrinone | CHEMBL12856 | Cordemcura | IN...)
Affinity DataKi:  5.93E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465483(CHEMBL4291350)
Affinity DataKi:  6.39E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465487(CHEMBL1605269)
Affinity DataKi:  7.03E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465489(CHEMBL1201292)
Affinity DataKi:  9.72E+4nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465477(CHEMBL4285109)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465495(CHEMBL4278218)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM15296(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465493(CHEMBL4281678)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465494(CHEMBL4279867)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465491(CHEMBL4278538)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465480(CHEMBL4282410)
Affinity DataKi:  1.03E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50465479(CHEMBL4286709)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM47224(US9073917, 2-inventive)
Affinity DataIC50:  1nMAssay Description:The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50175305(CHEMBL3600873)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Aurora-B/INCENP (unknown origin) using biotinylated STK2 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167515(US9073917, 12- comparative)
Affinity DataIC50:  3nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167510(US9073917, 7- comparative)
Affinity DataIC50:  4nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167506(US9073917, 1-inventive)
Affinity DataIC50:  4nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167508(US9073917, 5- comparative)
Affinity DataIC50:  6nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167507(US9073917, 4- comparative)
Affinity DataIC50:  6nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574278(CHEMBL4854144)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167512(US9073917, 11- comparative | US9073917, 9- compara...)
Affinity DataIC50:  8nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167513(US9073917, 10- comparative)
Affinity DataIC50:  9nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167516(US9073917, 13- comparative)
Affinity DataIC50:  10nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167509(US9073917, 6- comparative)
Affinity DataIC50:  13nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM209861(5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Aurora B/INCENP (unknown origin) pre-incubated for 1 hr followed by FL-PKAtide substrate and ATP additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50244953(CHEMBL4063500)
Affinity DataIC50:  19nMAssay Description:Binding affinity towards [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in HG108-15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM167511(US9073917, 8- comparative)
Affinity DataIC50:  21nMAssay Description:The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574272(CHEMBL4875416)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574268(CHEMBL4851020)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574269(CHEMBL4857965)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574270(CHEMBL4855657)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574279(CHEMBL4869229)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Nirma University

Curated by ChEMBL
LigandPNGBDBM50574274(CHEMBL4860970)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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