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Found 3760 Enz. Inhib. hit(s) with Target = 'Cathepsin S'
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546794(CHEMBL4777335)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546794(CHEMBL4777335)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of recombinant human cathepsin S using Z-VVR-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi: <0.100nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50030745(CHEMBL3342185 | acs.jmedchem.1c00409_ST.412)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335289(CHEMBL1651361 | N-{4-[5-(2-Thienyl)-1,2,4-oxadiazo...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335281(CHEMBL1651355 | N-(Phenylcarbamoyl)-leucyl-methyla...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335283(CHEMBL1651357 | N-{4-[5-(2-Thienyl)-1,2,4-oxadiazo...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335282(CHEMBL1651356 | N-[4-(5-Methyl-1,2,4-oxadiazol-3-y...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50030746(CHEMBL3342184 | acs.jmedchem.1c00409_ST.413)
Affinity DataKi:  0.176nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335284(CHEMBL1651349 | N-[4-(5-Methyl-1,2,4-oxadiazol-3-y...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335280(CHEMBL1651354 | N-(Benzylcarbamoyl)-leucyl-methyla...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335278(CHEMBL1651352 | N-(Benzyloxycarbonyl)-cyclohexylal...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546795(CHEMBL4777740)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50546796(CHEMBL4761229)
Affinity DataKi:  0.25nMAssay Description:Inhibition of recombinant human Cathepsin S expressed in baculovirus infected insect cells using Z-VVR-AMC as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50410979(CHEMBL207347)
Affinity DataKi: <0.25nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50084650(CHEMBL177914 | {(S)-1-[(S)-1-Formyl-2-(4-hydroxy-p...)
Affinity DataKi:  0.260nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109847(US8609681, 70)
Affinity DataKi:  0.300nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335285(CHEMBL1651350 | N-{4-[5-(2-Thienyl)-1,2,4-oxadiazo...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50304794((S)-benzyl 1-(2-cyano-1,2-dimethylhydrazinyl)-4-me...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM103367(US8552202, Example 4)
Affinity DataKi:  0.400nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109859(US8609681, 102)
Affinity DataKi:  0.5nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50304793((S)-benzyl 1-(2-cyano-1,2-dimethylhydrazinyl)-1-ox...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50392215(CHEMBL2153161)
Affinity DataKi:  0.550nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Val-Arg-pNA as substrate after 80 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50002399(CHEMBL197958)
Affinity DataKi:  0.560nMAssay Description:Apparent inhibitory constant against human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255571(4-(3-Cyano-benzenesulfonylamino)-N-[1-(2S-ethyl-4-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255790(4-(2,4-Dimethyl-thiazole-5-sulfonylamino)-N-[1-(2S...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50030747(CHEMBL3342183)
Affinity DataKi:  0.777nMAssay Description:Inhibition of human cathepsin S using Z-Phe-Arg-AMC fluorogenic substrate fluorogenic substrate incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255133(4-Benzenesulfonylamino-N-[1-(2S-ethyl-4-oxo-tetrah...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255627(4-(2-Cyano-benzenesulfonylamino)-N-[1-(2S-ethyl-4-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335277(CHEMBL1651351 | N-(Benzyloxycarbonyl)-isoleucyl-me...)
Affinity DataKi:  0.830nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335279(CHEMBL1651353 | N-(Benzyloxycarbonyl)-tyrosyl-meth...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255681(CHEMBL473448 | N-[1-(2S-Ethyl-4-oxo-tetrahydro-fur...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM19622((2S)-2-[(7-chloro-1,3-benzoxazol-2-yl)amino]-3-cyc...)
Affinity DataKi:  1nM ΔG°:  -53.4kJ/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255569(CHEMBL475669 | N-[1-(2S-Ethyl-4-oxo-tetrahydro-fur...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109858(US8609681, 97)
Affinity DataKi:  1nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255570(4-(4-Cyano-benzenesulfonylamino)-N-[1-(2S-ethyl-4-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255499(4-(4-Amino-benzenesulfonylamino)-N-[1-(2S-ethyl-4-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50335276(CHEMBL1651242 | N-(Benzyloxycarbonyl)-valyl-methyl...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human cathepsin S after 30 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  1.60nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM103364(US8552202, Compound 13)
Affinity DataKi:  1.70nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50032805(CHEMBL107495 | N-[2-(3-Morpholin-4-yl-ureido)-1-na...)
Affinity DataKi:  1.80nMAssay Description:Compound is evaluated for inhibitory potency against cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255949(4-Ethanesulfonylamino-N-[1-(2S-ethyl-4-oxo-tetrahy...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM19577((2S)-3-cyclohexyl-2-({4-[(4,6-dimethylpyrimidin-2-...)
Affinity DataKi:  2nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255456(CHEMBL474664 | N-[1-(2S-Ethyl-4-oxo-tetrahydro-fur...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50463221(CHEMBL4251253)
Affinity DataKi:  2nMAssay Description:Inhibition of human cathepsin S using Z-LR-AMC as substrate after 30 mins by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109857(US8609681, 94)
Affinity DataKi:  2nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109856(US8609681, 91)
Affinity DataKi:  2nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM109839(US8609681, 36)
Affinity DataKi:  2nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM50255629(CHEMBL480638 | N-[1-(2S-Ethyl-4-oxo-tetrahydro-fur...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Grunenthal

Curated by ChEMBL
LigandPNGBDBM103361(US8552202, Example 2)
Affinity DataKi:  2.20nMAssay Description:In vitro inhibition assay using cathepsin.More data for this Ligand-Target Pair
In DepthDetails US Patent
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